Institution
University College Cork
Education•Cork, Ireland•
About: University College Cork is a education organization based out in Cork, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 12056 authors who have published 28452 publications receiving 958414 citations. The organization is also known as: Coláiste na hOllscoile Corcaigh & National University of Ireland, Cork.
Topics: Population, Context (language use), Irish, Gut flora, Health care
Papers published on a yearly basis
Papers
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TL;DR: The proposed WFPV HR estimation algorithm has a low computational cost and can be used for fitness tracking and health monitoring in wearable devices and in contrast to existing alternatives has very few free parameters to tune.
Abstract: Objective : The challenging task of heart rate (HR) estimation from the photoplethysmographic (PPG) signal, during intensive physical exercises, is tackled in this paper. Methods: The study presents a detailed analysis of a novel algorithm (WFPV) that exploits a Wiener filter to attenuate the motion artifacts, a phase vocoder to refine the HR estimate and user-adaptive post-processing to track the subject physiology. Additionally, an offline version of the HR estimation algorithm that uses Viterbi decoding is designed for scenarios that do not require online HR monitoring (WFPV+VD). The performance of the HR estimation systems is rigorously compared with existing algorithms on the publically available database of 23 PPG recordings. Results: On the whole dataset of 23 PPG recordings, the algorithms result in average absolute errors of 1.97 and 1.37 BPM in the online and offline modes, respectively. On the test dataset of 10 PPG recordings which were most corrupted with motion artifacts, WFPV has an error of 2.95 BPM on its own and 2.32 BPM in an ensemble with two existing algorithms. Conclusion: The error rate is significantly reduced when compared with the state-of-the art PPG-based HR estimation methods. Significance : The proposed system is shown to be accurate in the presence of strong motion artifacts and in contrast to existing alternatives has very few free parameters to tune. The algorithm has a low computational cost and can be used for fitness tracking and health monitoring in wearable devices. The MATLAB implementation of the algorithm is provided online.
189 citations
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University College Dublin1, University at Buffalo2, Charles University in Prague3, Ludwig Maximilian University of Munich4, Boston Children's Hospital5, Case Western Reserve University6, Children's Medical Research Institute7, University of Toronto8, Paris-Sorbonne University9, University College Cork10, University of Paris11, Vertex Pharmaceuticals12
TL;DR: At 144 weeks of treatment, ivacaftor was well tolerated, with no new safety concerns, and provided durable effects for 144 weeks in patients who had received active treatment in the placebo-controlled study.
189 citations
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TL;DR: Considering the differences in suicidal intent between males and females highlighted by the current study, gender targeted prevention and intervention strategies would be recommended.
Abstract: Suicide accounts for over 58,000 deaths in Europe per annum, where suicide attempts are estimated to be 20 times higher. Males have been found to have a disproportionately lower rate of suicide attempts and an excessively higher rate of suicides compared to females. The gender difference in suicide intent is postulated to contribute towards this gender imbalance. The aim of this study is to explore gender differences in suicide intent in a cross-national study of suicide attempts. The secondary aims are to investigate the gender differences in suicide attempt across age and country. Data on suicide attempts (acquired from the EU-funded OSPI-Europe project) was obtained from eight regions in Germany, Hungary, Ireland and Portugal. Suicide intent data was categorized into ‘Non-habitual Deliberate Self-Harm’ (DSH), ‘Parasuicidal Pause’ (SP), ‘Parasuicidal Gesture’ (SG), and ‘Serious Suicide Attempt’ (SSA), applying the Feuerlein scale. Gender differences in intent were explored for significance by using χ2-tests, odds ratios, and regression analyses. Suicide intent data from 5212 participants was included in the analysis. A significant association between suicide intent and gender was found, where ‘Serious Suicide Attempts’ (SSA) were rated significantly more frequently in males than females (p < .001). There was a statistically significant gender difference in intent and age groups (p < .001) and between countries (p < .001). Furthermore, within the most utilised method, intentional drug overdose, ‘Serious Suicide Attempt’ (SSA) was rated significantly more often for males than females (p < .005). Considering the differences in suicidal intent between males and females highlighted by the current study, gender targeted prevention and intervention strategies would be recommended.
189 citations
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Ben-Gurion University of the Negev1, Northwestern University2, Technion – Israel Institute of Technology3, Temple University4, University College Cork5, Swiss Federal Institute of Aquatic Science and Technology6, ETH Zurich7, Ca' Foscari University of Venice8, Karlsruhe Institute of Technology9, Tel Aviv University10, Israel Ministry of Health11, University of Girona12, Catalan Institute for Water Research13, University of Notre Dame14, Yale University15, Rice University16, Commonwealth Scientific and Industrial Research Organisation17, Drexel University18, University of Illinois at Urbana–Champaign19, Tianjin Polytechnic University20
TL;DR: In this article, the authors present a risk assessment and management framework tailored to SARS-CoV-2 transmission via wastewater, including new tools for environmental surveillance, ensuring adequate disinfection as a component of overall COVID-19 pandemic containment.
Abstract: The COVID-19 pandemic has severely impacted public health and the worldwide economy Converging evidence from the current pandemic, previous outbreaks and controlled experiments indicates that SARS-CoVs are present in wastewater for several days, leading to potential health risks via waterborne and aerosolized wastewater pathways Conventional wastewater treatment provides only partial removal of SARS-CoVs, thus safe disposal or reuse will depend on the efficacy of final disinfection This underscores the need for a risk assessment and management framework tailored to SARS-CoV-2 transmission via wastewater, including new tools for environmental surveillance, ensuring adequate disinfection as a component of overall COVID-19 pandemic containment Converging evidence indicates that SARS-CoVs are present in wastewater for several days with potential health risks This Review analyses knowledge about such risks as well as the potential spread of SARS-CoVs in waterborne, waterborne–aerosolized and waterborne–foodborne pathways during a pandemic
189 citations
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TL;DR: Comparative genomic analysis revealed that in the four readthrough candidates containing UGA-CUAG, this motif is conserved not only in mammals but throughout vertebrates with the first six of the seven nucleotides being universally conserved.
Abstract: Stop codon readthrough is used extensively by viruses to expand their gene expression. Until recent discoveries in Drosophila, only a very limited number of readthrough cases in chromosomal genes had been reported. Analysis of conserved protein coding signatures that extend beyond annotated stop codons identified potential stop codon readthrough of four mammalian genes. Here we use a modified targeted bioinformatic approach to identify a further three mammalian readthrough candidates. All seven genes were tested experimentally using reporter constructs transfected into HEK-293T cells. Four displayed efficient stop codon readthrough, and these have UGA immediately followed by CUAG. Comparative genomic analysis revealed that in the four readthrough candidates containing UGA-CUAG, this motif is conserved not only in mammals but throughout vertebrates with the first six of the seven nucleotides being universally conserved. The importance of the CUAG motif was confirmed using a systematic mutagenesis approach. One gene, OPRL1, encoding an opiate receptor, displayed extremely efficient levels of readthrough (∼31%) in HEK-293T cells. Signals both 5 � and 3 � of the OPRL1 stop
189 citations
Authors
Showing all 12300 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stephen J. O'Brien | 153 | 1062 | 93025 |
James J. Collins | 151 | 669 | 89476 |
J. Wouter Jukema | 124 | 785 | 61555 |
John F. Cryan | 124 | 723 | 58938 |
Fergus Shanahan | 117 | 705 | 51963 |
Timothy G. Dinan | 116 | 689 | 60561 |
John M. Starr | 116 | 695 | 48761 |
Gordon G. Wallace | 114 | 1267 | 69095 |
Colin Hill | 112 | 693 | 54484 |
Robert Clarke | 111 | 512 | 90049 |
Douglas B. Kell | 111 | 634 | 50335 |
Thomas Bein | 109 | 677 | 42800 |
Steven C. Hayes | 106 | 450 | 51556 |
Åke Borg | 105 | 444 | 53835 |
Eamonn Martin Quigley | 103 | 685 | 39585 |