Institution
University College Cork
Education•Cork, Ireland•
About: University College Cork is a education organization based out in Cork, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 12056 authors who have published 28452 publications receiving 958414 citations. The organization is also known as: Coláiste na hOllscoile Corcaigh & National University of Ireland, Cork.
Topics: Population, Context (language use), Irish, Gut flora, Health care
Papers published on a yearly basis
Papers
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TL;DR: Both the pro- and anti-tumorigenic effects identified for almost all members of the IL-1 family of cytokines are highlighted, and potential underlying mechanisms accounting for these divergent effects are explored.
Abstract: The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in modulating both the innate and adaptive immunes response, with dysregulation linked to a variety of autoimmune and inflammatory diseases. Given the increasing appreciation of the link between inflammation and cancer, the role of several members of this family in the pathogenesis of cancer has been extensively investigated. In this review, we highlight both the pro- and anti-tumorigenic effects identified for almost all members of this family, and explore potential underlying mechanisms accounting for these divergent effects. Such dual functions need to be carefully assessed when developing therapeutic intervention strategies targeting these cytokines in cancer.
172 citations
TL;DR: In this paper, new geriatric IP criteria have been devised and validated, called screening tool of older persons' prescriptions (STOPP) and screening tool to alert to right treatment (START) for detection of potential errors of prescribing commission and omission.
172 citations
TL;DR: A simple facies model for terminal fans and their deposits is presented in this article, which includes a tripartite zonation of terminal fans into feeder, distributary and basinal zones.
172 citations
TL;DR: Data indicate that mature Cheddar cheese compares very favorably with fresh yogurt as a delivery system for viable probiotic microorganisms to the gastrointestinal tract.
172 citations
TL;DR: It is demonstrated that light-induced photoreceptor apoptosis in vivo is mediated by the activation of nNOS and guanylate cyclase and is caspase-3-independent.
171 citations
Authors
Showing all 12300 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Stephen J. O'Brien | 153 | 1062 | 93025 |
| James J. Collins | 151 | 669 | 89476 |
| J. Wouter Jukema | 124 | 785 | 61555 |
| John F. Cryan | 124 | 723 | 58938 |
| Fergus Shanahan | 117 | 705 | 51963 |
| Timothy G. Dinan | 116 | 689 | 60561 |
| John M. Starr | 116 | 695 | 48761 |
| Gordon G. Wallace | 114 | 1267 | 69095 |
| Colin Hill | 112 | 693 | 54484 |
| Robert Clarke | 111 | 512 | 90049 |
| Douglas B. Kell | 111 | 634 | 50335 |
| Thomas Bein | 109 | 677 | 42800 |
| Steven C. Hayes | 106 | 450 | 51556 |
| Åke Borg | 105 | 444 | 53835 |
| Eamonn Martin Quigley | 103 | 685 | 39585 |