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Institution

University College Cork

EducationCork, Ireland
About: University College Cork is a education organization based out in Cork, Ireland. It is known for research contribution in the topics: Population & Irish. The organization has 12056 authors who have published 28452 publications receiving 958414 citations. The organization is also known as: Coláiste na hOllscoile Corcaigh & National University of Ireland, Cork.
Topics: Population, Irish, Gut flora, Microbiome, Casein


Papers
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Journal ArticleDOI
TL;DR: Consensus guidelines are presented on central aspects of CAR assessment, including objective control of sampling accuracy/adherence, participant instructions, covariate accounting, sampling protocols, quantification strategies as well as reporting and interpreting of CAR data.

716 citations

Journal ArticleDOI
04 Dec 2015-Science
TL;DR: Detailed analyses have separated the microbiota into groups associated with age, long-term residential care, habitual diet, and degree of retention of a core microbiome, which provide a framework for analyzing microbiota-health associations and developing microbiota-based health surveillance for older adults.
Abstract: The potential for the gut microbiota to affect health has a particular relevance for older individuals. This is because the microbiota may modulate aging-related changes in innate immunity, sarcopaenia, and cognitive function, all of which are elements of frailty. Both cell culture-dependent and -independent studies show that the gut microbiota of older people differs from that of younger adults. There is no chronological threshold or age at which the composition of the microbiota suddenly alters; rather, changes occur gradually with time. Our detailed analyses have separated the microbiota into groups associated with age, long-term residential care, habitual diet, and degree of retention of a core microbiome. We are beginning to understand how these groups change with aging and how they relate to clinical phenotypes. These data provide a framework for analyzing microbiota-health associations, distinguishing correlation from causation, identifying microbiota interaction with physiological aging processes, and developing microbiota-based health surveillance for older adults.

714 citations

Journal ArticleDOI
TL;DR: It would appear that the mitochondrial release of factors such as cytochrome c represents a critical step in committing a cell to death, and this release is independent of permeability transition and caspase activation but is inhibited by Bcl-xL.

713 citations

Journal ArticleDOI
TL;DR: These guidelines were developed under the auspices of the American College of Gastroenterology by a committee of experts in the field, reviewed by its Practice Parameters Committee, and approved by the Board of Trustees to be considered valid at the time of production based on the data available.

712 citations

Journal ArticleDOI
TL;DR: In this paper, the authors consider the impact of tourism at two levels: (1) that created by the sheer numbers of tourists and their demands (mass tourism and transport) and (2) that resulting from individual, often novel, forms of transport (personal leisure transport).
Abstract: Coastal tourism started in the 19th Century and has increased in non-linear fashion ever since, stimulated by a combination of developments in transport technology and rising prosperity. Initially, mainly national in character, the introduction of roll-on, roll-off ferries and inexpensive air transport caused an exponential 28-fold rise in international tourism between 1950 and the start of the 21st Century. This review considers the impact of tourism at two levels: (1) that created by the sheer numbers of tourists and their demands (‘mass tourism and transport’) and (2) that resulting from individual, often novel, forms of transport (‘personal leisure transport’). Under (1), the consequences of the construction of coastal resorts and roads, marinas and jetties for habitat fragmentation and reduced biodiversity are described. Next, the effects of large cruise ships (now some 250 in number) are considered, particularly in relation to unregulated pollution and the delivery of substantial numbers of tourists to remote destinations. Thirdly, the literature related to disturbance caused by intertidal trampling by tourists on rocky/sandy shores is reviewed, followed by a section devoted to the unappreciated effects of beach ‘cleaning’ (i.e. removal of natural strandlines as well as litter) that is practiced throughout the world’s sandy beach resorts. Finally, the potentially positive area of coastal ecotourism is considered, but evidence is assembled to highlight the problems associated with too high a demand. Under (2), the impact of a range of personal leisure transport modes is considered. These range from relatively innocuous pursuits (e.g. swimming, surfing, sailboarding and dinghy sailing), to an extremely popular sport (SCUBA diving) that is marketed for its environmentally-friendly nature, yet causes measurable deterioration in the world’s coral ecosystems despite good management practices. The impact of motorboats is considered, particularly in the context of transmission of non-native species, while the highly polluting and disturbing technology of ‘personal watercraft’ is evaluated. Finally, the uncontrolled emergence of new ‘extreme sports’ (e.g. ‘coasteering’, kitesurfing) is identified as a future problem. 2005 Elsevier Ltd. All rights reserved.

712 citations


Authors

Showing all 12300 results

NameH-indexPapersCitations
Stephen J. O'Brien153106293025
James J. Collins15166989476
J. Wouter Jukema12478561555
John F. Cryan12472358938
Fergus Shanahan11770551963
Timothy G. Dinan11668960561
John M. Starr11669548761
Gordon G. Wallace114126769095
Colin Hill11269354484
Robert Clarke11151290049
Douglas B. Kell11163450335
Thomas Bein10967742800
Steven C. Hayes10645051556
Åke Borg10544453835
Eamonn Martin Quigley10368539585
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202381
2022400
20212,153
20201,927
20191,679
20181,618