Institution
University College Cork
Education•Cork, Ireland•
About: University College Cork is a education organization based out in Cork, Ireland. It is known for research contribution in the topics: Population & Irish. The organization has 12056 authors who have published 28452 publications receiving 958414 citations. The organization is also known as: Coláiste na hOllscoile Corcaigh & National University of Ireland, Cork.
Topics: Population, Irish, Gut flora, Microbiome, Casein
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the B. longum 1714 strain was identified as a putative psychobiotic with an impact on stress-related behaviors, physiology and cognitive performance in healthy human volunteers.
Abstract: The emerging concept of psychobiotics—live microorganisms with a potential mental health benefit—represents a novel approach for the management of stress-related conditions. The majority of studies have focused on animal models. Recent preclinical studies have identified the B. longum 1714 strain as a putative psychobiotic with an impact on stress-related behaviors, physiology and cognitive performance. Whether such preclinical effects could be translated to healthy human volunteers remains unknown. We tested whether psychobiotic consumption could affect the stress response, cognition and brain activity patterns. In a within-participants design, healthy volunteers (N=22) completed cognitive assessments, resting electroencephalography and were exposed to a socially evaluated cold pressor test at baseline, post-placebo and post-psychobiotic. Increases in cortisol output and subjective anxiety in response to the socially evaluated cold pressor test were attenuated. Furthermore, daily reported stress was reduced by psychobiotic consumption. We also observed subtle improvements in hippocampus-dependent visuospatial memory performance, as well as enhanced frontal midline electroencephalographic mobility following psychobiotic consumption. These subtle but clear benefits are in line with the predicted impact from preclinical screening platforms. Our results indicate that consumption of B. longum 1714 is associated with reduced stress and improved memory. Further studies are warranted to evaluate the benefits of this putative psychobiotic in relevant stress-related conditions and to unravel the mechanisms underlying such effects.
328 citations
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TL;DR: It is evident from this review that there is potential for more accurate estimation of SMC exploiting EO technology, particularly so, by exploring the use of synergistic approaches between a variety of EO instruments.
Abstract: Advances in Earth Observation (EO) technology, particularly over the last two decades, have shown that soil moisture content (SMC) can be measured to some degree or other by all regions of the electromagnetic spectrum, and a variety of techniques have been proposed to facilitate this purpose.
In this review we provide a synthesis of the efforts made during the last 20 years or so towards the estimation of surface SMC exploiting EO imagery, with a particular emphasis on retrievals from microwave sensors. Rather than replicating previous overview works, we provide a comprehensive and critical exploration of all the major approaches employed for retrieving SMC in a range of different global ecosystems. In this framework, we consider the newest techniques developed within optical and thermal infrared remote sensing, active and passive microwave domains, as well as assimilation or synergistic approaches. Future trends and prospects of EO for the accurate determination of SMC from space are subject to key challenges, some of which are identified and discussed within.
It is evident from this review that there is potential for more accurate estimation of SMC exploiting EO technology, particularly so, by exploring the use of synergistic approaches between a variety of EO instruments. Given the importance of SMC in Earth’s land surface interactions and to a large range of applications, one can appreciate that its accurate estimation is critical in addressing key scientific and practical challenges in today’s world such as food security, sustainable planning and management of water resources. The launch of new, more sophisticated satellites strengthens the development of innovative research approaches and scientific inventions that will result in a range of pioneering and ground-breaking advancements in the retrievals of soil moisture from space.
328 citations
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TL;DR: Pretherapy FMISO uptake shows a strong trend to be an independent prognostic measure in head and neck cancer.
Abstract: Purpose: Advanced head and neck cancer shows hypoxia that results in biological changes to make the tumor cells more aggressive and less responsive to treatment resulting in poor survival. [F-18] fluoromisonidazole (FMISO) positron emission tomography (PET) has the ability to noninvasively quantify regional hypoxia. We investigated the prognostic effect of pretherapy FMISO-PET on survival in head and neck cancer. Experimental Design: Seventy-three patients with head and neck cancer had pretherapy FMISO-PET and 53 also had fluorodeoxyglucose (FDG) PET under a research protocol from April 1994 to April 2004. Results: Significant hypoxia was identified in 58 patients (79%). The mean FMISO tumor/blood max (T/B max ) was 1.6 and the mean hypoxic volume (HV) was 40.2 mL. There were 28 deaths in the follow-up period. Mean FDG standard uptake value (SUV) max was 10.8. The median time for follow-up was 72 weeks. In a univariate analysis, T/B max ( P = 0.002), HV ( P = 0.04), and the presence of nodes ( P = 0.01) were strong independent predictors. In a multivariate analysis, including FDG SUV max , no variable was predictive at P max was removed from the model (resulting in n = 73 with 28 events), nodal status and T/B max (or HV) were both highly predictive ( P = 0.02, 0.006 for node and T/B max , respectively; P = 0.02 and 0.001 for node and HV, respectively). Conclusions: Pretherapy FMISO uptake shows a strong trend to be an independent prognostic measure in head and neck cancer.
326 citations
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TL;DR: Cheese is the most diverse group of dairy products and is, arguably, the most academically interesting and challenging as mentioned in this paper, and it represents a finely orchestrated series of consecutive and concomitant biochemical events, which, if synchronized and balanced, lead to products with highly desirable aromas and flavors but when unbalanced, result in off-flavors and odors.
Abstract: Cheese is the most diverse group of dairy products and is, arguably, the most academically interesting and challenging. While most dairy products, if properly manufactured and stored, are biologically, biochemically, chemically, and physically very stable, cheeses are biologically and biochemically dynamic, and are inherently unstable. Throughout manufacture and ripening, cheese production represents a finely orchestrated series of consecutive and concomitant biochemical events, which, if synchronized and balanced, lead to products with highly desirable aromas and flavors but when unbalanced, result in off-flavors and odors.
326 citations
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University College of Medical Sciences1, Kyoto University2, Crozer-Keystone Health System3, Alexandria University4, Nagasaki University5, University of Split6, University of Newcastle7, Queen Mary University of London8, University of Perugia9, University College Cork10, Kobe University11, University of Twente12, Vrije Universiteit Brussel13, University of Hong Kong14, Kwame Nkrumah University of Science and Technology15, Ho Chi Minh City Medicine and Pharmacy University16, University of Bern17, University of Helsinki18, RAND Corporation19, University of Sydney20, University of Barcelona21, University of Vienna22, University of British Columbia23, Kerman Medical University24
325 citations
Authors
Showing all 12300 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stephen J. O'Brien | 153 | 1062 | 93025 |
James J. Collins | 151 | 669 | 89476 |
J. Wouter Jukema | 124 | 785 | 61555 |
John F. Cryan | 124 | 723 | 58938 |
Fergus Shanahan | 117 | 705 | 51963 |
Timothy G. Dinan | 116 | 689 | 60561 |
John M. Starr | 116 | 695 | 48761 |
Gordon G. Wallace | 114 | 1267 | 69095 |
Colin Hill | 112 | 693 | 54484 |
Robert Clarke | 111 | 512 | 90049 |
Douglas B. Kell | 111 | 634 | 50335 |
Thomas Bein | 109 | 677 | 42800 |
Steven C. Hayes | 106 | 450 | 51556 |
Åke Borg | 105 | 444 | 53835 |
Eamonn Martin Quigley | 103 | 685 | 39585 |