Institution
University College Cork
Education•Cork, Ireland•
About: University College Cork is a education organization based out in Cork, Ireland. It is known for research contribution in the topics: Population & Irish. The organization has 12056 authors who have published 28452 publications receiving 958414 citations. The organization is also known as: Coláiste na hOllscoile Corcaigh & National University of Ireland, Cork.
Topics: Population, Irish, Gut flora, Microbiome, Casein
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10 Dec 2000
TL;DR: A framework was derived from two previous frameworks which have been very influential in the IS field, namely that of Zachman's IS architecture (ISA) and Checkland's CATWOE framework from Soft Systems Methodology (SSM), which is used to analyze the OSS approach in detail.
Abstract: Open Source Software (OSS) has become the subject of much commercial interest of late. Certainly, OSS seems to hold much promise in addressing the core issues of the software crisis, namely that of software taking too long to develop, exceeding its budget, and not working very well. Indeed, there have been several examples of significant OSS success stories—the Linux operating system, the Apache web server, the BIND domain name resolution utility, to name but a few. However, little by way of rigorous academic research on OSS has been conducted to date. In this study, a framework was derived from two previous frameworks which have been very influential in the IS field, namely that of Zachman’s IS architecture (ISA) and Checkland’s CATWOE framework from Soft Systems Methodology (SSM). The resulting framework is used to analyze the OSS approach in detail. The potential future of OSS research is also discussed.
296 citations
TL;DR: A systematic review on the Management of Chronic Constipation in North America Lawrence J. Brandt, M.D., M.A.C.P., F.R.CC.G.P, and Philip Schoenfeld of the National University of Ireland's Gastroenterology and Hepatology Center finds that chronic constipation is a major cause of disability in women in the United States.
295 citations
TL;DR: Flavonoid modulation of COX-2 transcription may be an important mechanism in anti-carcinogenesis and some new preliminary data on Vitamin E and quercetin conjugates are reported.
Abstract: Cyclooxygenase-2 (COX-2)-catalysed synthesis of prostaglandin E2 plays a key role in inflammation and its associated diseases, such as cancer and cardiovascular disease. There are numerous reports demonstrating that flavonoids inhibit COX-2 activity. However, transcriptional regulation of COX-2 can also be important. Nobiletin, amentoflavone, quercetin, quercetin penta-acetate, flavone, resveratrol, apigenin, chrysin, kaempferol, galangin, and genistein have been reported to modulate COX-2 transcription in a wide variety of systems. Here, we briefly review the literature on regulation of COX-2 transcription by flavonoids, and report some new preliminary data on Vitamin E and quercetin conjugates. Quercetin, quercetin 3-glucuronide, quercetin 3'-sulfate and 3'methylquercetin 3-glucuronide reduced COX-2 mRNA expression in both unstimulated and interleukin-1beta stimulated colon cancer (Caco2) cells. Quercetin and quercetin 3'-sulfate, unlike quercetin 3-glucuronide and 3'methylquercetin 3-glucuronide, also inhibited COX-2 activity. In contrast, tocopherols (alpha-tocopherol, alpha-tocopherol acetate, and gamma-tocopherol at 10microM) did not affect COX-2 mRNA expression in unstimulated Caco2 cells. However, the tocopherols inhibited COX-2 activity showing that the tocopherols act post-transcriptionally on activity, whereas quercetin and some quercetin conjugates affect both the transcription and activity of COX-2. Flavonoid modulation of COX-2 transcription may therefore be an important mechanism in anti-carcinogenesis.
295 citations
State University of New York Upstate Medical University1, Heidelberg University2, University of Melbourne3, Capital Medical University4, Harvard University5, Monash University, Clayton campus6, Icahn School of Medicine at Mount Sinai7, Montreal Children's Hospital8, Universidade Federal do Rio Grande do Sul9, Peking University10, University of Southampton11, University of Toronto12, University of Washington13, King Khalid University14, King's College London15, Aga Khan University16, Karolinska Institutet17, Radboud University Nijmegen18, Vrije Universiteit Brussel19, University of Nottingham20, Aarhus University21, University of Cologne22, Trinity College, Dublin23, University of Würzburg24, University of Bergen25, University Medical Center Groningen26, University of Wyoming27, University of California, San Francisco28, University of California, Berkeley29, Nottinghamshire Healthcare NHS Foundation Trust30, Duke University31, University of Amsterdam32, Örebro University33, Chongqing Medical University34, Tel Aviv University35, Washington University in St. Louis36, Federal University of Rio de Janeiro37, University College Cork38, University of British Columbia39, University of Pittsburgh40, Oregon Health & Science University41, University of Montpellier42, University of Ibadan43, University of São Paulo44, Hebrew University of Jerusalem45, University of Sydney46, Jawaharlal Institute of Postgraduate Medical Education and Research47, University of Canterbury48, Autonomous University of Barcelona49, Stellenbosch University50, University of California, Davis51, National Medical College52, Hofstra University53, University of Texas Health Science Center at Houston54, University of Southern Denmark55, University of California, Irvine56, Cardiff University57, Okinawa Institute of Science and Technology58, HU University of Applied Sciences Utrecht59, Katholieke Universiteit Leuven60, University of the Free State61, University of Turin62, Johns Hopkins University63, University of Zurich64
TL;DR: In this article, the authors presented 208 empirically supported statements about ADHD using meta-analysis, which allow for firm statements about the nature, course, outcome causes and treatments for disorders that are useful for reducing misconceptions and stigma.
295 citations
TL;DR: In this paper, the authors reported the high-frequency modulation of individual pixels in 8 × 8 arrays of III-nitride-based micro-pixellated light-emitting diodes, where the pixels within the array range from 14 to 84 μ m in diameter.
Abstract: We report the high-frequency modulation of individual pixels in 8 × 8 arrays of III-nitride-based micro-pixellated light-emitting diodes, where the pixels within the array range from 14 to 84 μ m in diameter. The peak emission wavelengths of the devices are 370, 405, 450 and 520 nm, respectively. Smaller area micro-LED pixels generally exhibit higher modulation bandwidths than their larger area counterparts, which is attributed to their ability to be driven at higher current densities. The highest optical -3 dB modulation bandwidths from these devices are shown to be in excess of 400 MHz, which, to our knowledge, are the highest bandwidths yet reported for GaN LEDs. These devices are also integrated with a complementary metal-oxide-semiconductor (CMOS) driver array chip, allowing for simple computer control of individual micro-LED pixels. The bandwidth of the integrated micro-LED/CMOS pixels is shown to be up to 185 MHz; data transmission at bit rates up to 512 Mbit/s is demonstrated using on-off keying non return-to-zero modulation with a bit-error ratio of less than 1 × 10-10, using a 450 nm-emitting 24 μm diameter CMOS-controlled micro-LED. As the CMOS chip allows for up to 16 independent data inputs, this device demonstrates the potential for multi-Gigabit/s parallel data transmission using CMOS-controlled micro-LEDs.
295 citations
Authors
Showing all 12300 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Stephen J. O'Brien | 153 | 1062 | 93025 |
| James J. Collins | 151 | 669 | 89476 |
| J. Wouter Jukema | 124 | 785 | 61555 |
| John F. Cryan | 124 | 723 | 58938 |
| Fergus Shanahan | 117 | 705 | 51963 |
| Timothy G. Dinan | 116 | 689 | 60561 |
| John M. Starr | 116 | 695 | 48761 |
| Gordon G. Wallace | 114 | 1267 | 69095 |
| Colin Hill | 112 | 693 | 54484 |
| Robert Clarke | 111 | 512 | 90049 |
| Douglas B. Kell | 111 | 634 | 50335 |
| Thomas Bein | 109 | 677 | 42800 |
| Steven C. Hayes | 106 | 450 | 51556 |
| Åke Borg | 105 | 444 | 53835 |
| Eamonn Martin Quigley | 103 | 685 | 39585 |