Institution
University Hospital of Basel
Healthcare•Basel, Switzerland•
About: University Hospital of Basel is a healthcare organization based out in Basel, Switzerland. It is known for research contribution in the topics: Population & Transplantation. The organization has 8808 authors who have published 18518 publications receiving 647956 citations. The organization is also known as: University Hospital, Basel, Switzerland.
Topics: Population, Transplantation, Medicine, Cancer, Myocardial infarction
Papers published on a yearly basis
Papers
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TL;DR: The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.
Abstract: Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwide
13,324 citations
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TL;DR: The current guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation are based on the findings of the ESC Task Force on 12 March 2015.
Abstract: ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation : The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC).
6,866 citations
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TL;DR: The approach of GRADE to rating quality of evidence specifies four categories-high, moderate, low, and very low-that are applied to a body of evidence, not to individual studies.
5,228 citations
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TL;DR: Genetic evidence and in vitro functional studies indicate that V617F gives hematopoietic precursors proliferative and survival advantages and a high proportion of patients with myeloproliferative disorders carry a dominant gain-of-function mutation of JAK2.
Abstract: background Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors a mutation that contributes to the cause of clonal expansion of hematopoietic cells in these diseases. methods We performed microsatellite mapping of the 9pLOH region and DNA sequencing in 244 patients with myeloproliferative disorders (128 with polycythemia vera, 93 with essential thrombocythemia, and 23 with idiopathic myelofibrosis). results Microsatellite mapping identified a 9pLOH region that included the Janus kinase 2 ( JAK2 )
3,391 citations
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TL;DR: Preliminary results from clinical trials with salicylates and interleukin-1 antagonists support the notion that inflammation participates in the pathogenesis of type 2 diabetes and have opened the door for immunomodulatory strategies for the treatment of T2D that simultaneously lower blood glucose levels and potentially reduce the severity and prevalence of the associated complications of this disease.
Abstract: Components of the immune system are altered in obesity and type 2 diabetes (T2D), with the most apparent changes occurring in adipose tissue, the liver, pancreatic islets, the vasculature and circulating leukocytes. These immunological changes include altered levels of specific cytokines and chemokines, changes in the number and activation state of various leukocyte populations and increased apoptosis and tissue fibrosis. Together, these changes suggest that inflammation participates in the pathogenesis of T2D. Preliminary results from clinical trials with salicylates and interleukin-1 antagonists support this notion and have opened the door for immunomodulatory strategies for the treatment of T2D that simultaneously lower blood glucose levels and potentially reduce the severity and prevalence of the associated complications of this disease.
2,845 citations
Authors
Showing all 8885 results
Name | H-index | Papers | Citations |
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Edward Giovannucci | 206 | 1671 | 179875 |
Stephen R. Bloom | 134 | 747 | 71493 |
Philip McGuire | 133 | 881 | 60813 |
Chris H. Polman | 120 | 614 | 72652 |
Norbert Schwarz | 117 | 488 | 71008 |
Michael Horowitz | 112 | 982 | 46952 |
Ludwig Kappos | 109 | 769 | 68362 |
Caroline A. Sabin | 108 | 690 | 44233 |
Christopher E.M. Griffiths | 108 | 671 | 47675 |
Michael N. Hall | 107 | 312 | 48318 |
Stephen L. Hauser | 106 | 561 | 46248 |
Tomáš Paus | 105 | 467 | 49552 |
Holger Moch | 104 | 685 | 49609 |
Christian Schindler | 102 | 491 | 36104 |
Francisco Sánchez-Madrid | 102 | 527 | 43418 |