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Institution

University of Aberdeen

EducationAberdeen, United Kingdom
About: University of Aberdeen is a education organization based out in Aberdeen, United Kingdom. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 21174 authors who have published 49962 publications receiving 2105479 citations. The organization is also known as: Aberdeen University.


Papers
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Journal ArticleDOI
TL;DR: A new histological grading system, which assesses the histological response to primary chemotherapy, can predict overall survival and disease-free interval in patients with large and locally advanced breast cancers treated with such therapy.

740 citations

Journal ArticleDOI
TL;DR: It is suggested that other topics also need addressing, including better assessment of the wider benefits of intercropping in terms of multiple ecosystem services, collaboration with agricultural engineering, and more effective interdisciplinary research.
Abstract: Intercropping is a farming practice involving two or more crop species, or genotypes, growing together and coexisting for a time. On the fringes of modern intensive agriculture, intercropping is important in many subsistence or low-input/resource-limited agricultural systems. By allowing genuine yield gains without increased inputs, or greater stability of yield with decreased inputs, intercropping could be one route to delivering ‘sustainable intensification’. We discuss how recent knowledge from agronomy, plant physiology and ecology can be combined with the aim of improving intercropping systems. Recent advances in agronomy and plant physiology include better understanding of the mechanisms of interactions between crop genotypes and species – for example, enhanced resource availability through niche complementarity. Ecological advances include better understanding of the context-dependency of interactions, the mechanisms behind disease and pest avoidance, the links between above- and below-ground systems, and the role of microtopographic variation in coexistence. This improved understanding can guide approaches for improving intercropping systems, including breeding crops for intercropping. Although such advances can help to improve intercropping systems, we suggest that other topics also need addressing. These include better assessment of the wider benefits of intercropping in terms of multiple ecosystem services, collaboration with agricultural engineering, and more effective interdisciplinary research.

738 citations

Journal ArticleDOI
TL;DR: In this paper, age-of-acquisition, imagery, concreteness, familiarity, and ambiguity measures for 1,944 words of varying length and frequency of occurrence are presented.
Abstract: Age-of-acquisition, imagery, concreteness, familiarity, and ambiguity measures for 1,944 words of varying length and frequency of occurrence are presented. The words can all be used as nouns. Intergroup reliabilities are satisfactory on all attributes. Correlations with previous word lists are significant, and the intercorrelations between measures match previous findings.

736 citations

Journal ArticleDOI
TL;DR: It is argued that the pattern of age-related change observed is most consistent with a neuropsychological model of adult aging stemming from changes in frontal and temporal volume, and/or changes in neurotransmitters.

733 citations

Journal ArticleDOI
TL;DR: It is found that neutrophils sensed microbe size and selectively released neutrophil extracellular traps (NETs) in response to large pathogens, such as Candida albicans hyphae andextracellular aggregates of Mycobacterium bovis, but not inresponse to small yeast or single bacteria.
Abstract: Neutrophils are critical for antifungal defense, but the mechanisms that clear hyphae and other pathogens that are too large to be phagocytosed remain unknown. We found that neutrophils sensed microbe size and selectively released neutrophil extracellular traps (NETs) in response to large pathogens, such as Candida albicans hyphae and extracellular aggregates of Mycobacterium bovis, but not in response to small yeast or single bacteria. NETs were fundamental in countering large pathogens in vivo. Phagocytosis via dectin-1 acted as a sensor of microbe size and prevented NET release by downregulating the translocation of neutrophil elastase (NE) to the nucleus. Dectin-1 deficiency led to aberrant NET release and NET-mediated tissue damage during infection. Size-tailored neutrophil responses cleared large microbes and minimized pathology when microbes were small enough to be phagocytosed.

732 citations


Authors

Showing all 21424 results

NameH-indexPapersCitations
Paul M. Thompson1832271146736
Feng Zhang1721278181865
Ian J. Deary1661795114161
Peter A. R. Ade1621387138051
David W. Johnson1602714140778
Pete Smith1562464138819
Naveed Sattar1551326116368
John R. Hodges14981282709
Ruth J. F. Loos14264792485
Alan J. Silman14170892864
Michael J. Keating140116976353
David Price138168793535
John D. Scott13562583878
Aarno Palotie12971189975
Rajat Gupta126124072881
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023141
2022362
20212,195
20202,118
20191,846
20181,894