Institution
University of Adelaide
Education•Adelaide, South Australia, Australia•
About: University of Adelaide is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 27251 authors who have published 79167 publications receiving 2671128 citations. The organization is also known as: The University of Adelaide & Adelaide University.
Topics: Population, Poison control, Pregnancy, Health care, Mental health
Papers published on a yearly basis
Papers
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TL;DR: This review focuses on the recent advances in understanding of molecular mechanisms that commence after the gonadotrophin surge and culminate with release of the oocyte.
Abstract: Successful ovulation requires that developmentally competent oocytes are released with appropriate timing from the ovarian follicle. Somatic cells of the follicle sense the ovulatory stimulus and guide resumption of meiosis and release of the oocyte, as well as structural remodelling and luteinization of the follicle. Complex intercellular communication co-ordinates critical stages of oocyte maturation and links this process with release from the follicle. To achieve these outcomes, ovulation is controlled through multiple inputs, including endocrine hormones, immune and metabolic signals, as well as intrafollicular paracrine factors from the theca, mural and cumulus granulosa cells and the oocyte itself. This review focuses on the recent advances in understanding of molecular mechanisms that commence after the gonadotrophin surge and culminate with release of the oocyte. These mechanisms include intracellular signalling, gene regulation and remodelling of tissue structure in each of the distinct ovarian compartments. Most critical ovulatory mediators exert effects through the cumulus cell complex that surrounds and connects with the oocyte. The convergence of ovulatory signals through the cumulus complex co-ordinates the key mechanistic processes that mediate and control oocyte maturation and ovulation.
375 citations
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TL;DR: In this paper, three barley varieties contrasting in their salinity tolerance were used to assess the relative contribution of ionic, osmotic and oxidative stress components towards overall salinity stress tolerance in this species, both at the whole-plant and cellular levels.
Abstract: Salinity tolerance is a physiologically multi-faceted trait attributed to multiple mechanisms. Three barley (Hordeum vulgare) varieties contrasting in their salinity tolerance were used to assess the relative contribution of ionic, osmotic and oxidative stress components towards overall salinity stress tolerance in this species, both at the whole-plant and cellular levels. In addition, transcriptional changes in the gene expression profile were studied for key genes mediating plant ionic and oxidative homeostasis (NHX; RBOH; SOD; AHA and GORK), to compare a contribution of transcriptional and post-translational factors towards the specific components of salinity tolerance. Our major findings are two-fold. First, plant tissue tolerance was a dominating component that has determined the overall plant responses to salinity, with root K+ retention ability and reduced sensitivity to stress-induced hydroxyl radical production being the main contributing tolerance mechanisms. Second, it was not possible to infer which cultivars were salinity tolerant based solely on expression profiling of candidate genes at one specific time point. For the genes studied and the time point selected that transcriptional changes in the expression of these specific genes had a small role for barley’s adaptive responses to salinity. For better tissue tolerance, sodium sequestration, K+ retention and resistance to oxidative stress all appeared to be crucial. Because these traits are highly interrelated, it is suggested that a major progress in crop breeding for salinity tolerance can be achieved only if these complementary traits are targeted at the same time. This study also highlights the essentiality of post translational modifications in plant adaptive responses to salinity.
375 citations
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University of Queensland1, University of Adelaide2, University of Cambridge3, Centers for Disease Control and Prevention4, University of Groningen5, Boston Children's Hospital6, University of Liverpool7, Imperial College London8, Australian National University9, Harvard University10, Norwegian Institute of Public Health11
TL;DR: The present variation in stillbirth rates across and within high-income countries indicates that further reduction inStillbirth is possible, and international consensus on definition and classification related to stillbirth is a priority.
375 citations
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TL;DR: Pericardial fat is associated with the presence of AF, the severity ofAF, left atrial volumes, and poorer outcomes after AF ablation, and these associations are both independent of and stronger than more systemic measures of adiposity.
375 citations
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VU University Medical Center1, University of Alberta2, Edith Cowan University3, Netherlands Cancer Institute4, University of South Florida5, Utrecht University6, German Cancer Research Center7, Yale University8, Queensland University of Technology9, University of Maryland, Baltimore10, European University of Madrid11, Maastricht University12, University of Groningen13, University of Amsterdam14, University of Edinburgh15, University of Birmingham16, University of Glasgow17, University of Antwerp18, University of Oslo19, University of Hamburg20, University of Adelaide21, University of Newcastle22, Guy's and St Thomas' NHS Foundation Trust23, University Hospital Heidelberg24, King's College London25, Pennsylvania State University26, Oregon Health & Science University27, Johns Hopkins University28
TL;DR: In conclusion, exercise, and particularly supervised exercise, effectively improves QoL and PF in patients with cancer with different demographic and clinical characteristics during and following treatment.
374 citations
Authors
Showing all 27579 results
Name | H-index | Papers | Citations |
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Martin White | 196 | 2038 | 232387 |
Nicholas G. Martin | 192 | 1770 | 161952 |
David W. Johnson | 160 | 2714 | 140778 |
Nicholas J. Talley | 158 | 1571 | 90197 |
Mark E. Cooper | 158 | 1463 | 124887 |
Xiang Zhang | 154 | 1733 | 117576 |
John E. Morley | 154 | 1377 | 97021 |
Howard I. Scher | 151 | 944 | 101737 |
Christopher M. Dobson | 150 | 1008 | 105475 |
A. Artamonov | 150 | 1858 | 119791 |
Timothy P. Hughes | 145 | 831 | 91357 |
Christopher Hill | 144 | 1562 | 128098 |
Shi-Zhang Qiao | 142 | 523 | 80888 |
Paul Jackson | 141 | 1372 | 93464 |
H. A. Neal | 141 | 1903 | 115480 |