University of Adelaide

About: University of Adelaide is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Pregnancy. The organization has 27251 authors who have published 79167 publications receiving 2671128 citations. The organization is also known as: The University of Adelaide & Adelaide University.

High-performance fiber-reinforced concrete: a review

Abstract: In recent years, an emerging technology termed, “High-Performance Fiber-Reinforced Concrete (HPFRC)” has become popular in the construction industry. The materials used in HPFRC depend on the desired characteristics and the availability of suitable local economic alternative materials. Concrete is a common building material, generally weak in tension, often ridden with cracks due to plastic and drying shrinkage. The introduction of short discrete fibers into the concrete can be used to counteract and prevent the propagation of cracks. Despite an increase in interest to use HPFRC in concrete structures, some doubts still remain regarding the effect of fibers on the properties of concrete. This paper presents the most comprehensive review to date on the mechanical, physical, and durability-related features of concrete. Specifically, this literature review aims to provide a comprehensive review of the mechanism of crack formation and propagation, compressive strength, modulus of elasticity, stress–strain behavior, tensile strength (TS), flexural strength, drying shrinkage, creep, electrical resistance, and chloride migration resistance of HPFRC. In general, the addition of fibers in high-performance concrete has been proven to improve the mechanical properties of concrete, particularly the TS, flexural strength, and ductility performance. Furthermore, incorporation of fibers in concrete results in reductions in the shrinkage and creep deformations of concrete. However, it has been shown that fibers may also have negative effects on some properties of concrete, such as the workability, which get reduced with the addition of steel fibers. The addition of fibers, particularly steel fibers, due to their conductivity leads to a significant reduction in the electrical resistivity of the concrete, and it also results in some reduction in the chloride penetration resistance of the concrete.

Global trait–environment relationships of plant communities

Abstract: Plant functional traits directly affect ecosystem functions. At the species level, trait combinations depend on trade-offs representing different ecological strategies, but at the community level trait combinations are expected to be decoupled from these trade-offs because different strategies can facilitate co-existence within communities. A key question is to what extent community-level trait composition is globally filtered and how well it is related to global versus local environmental drivers. Here, we perform a global, plot-level analysis of trait-environment relationships, using a database with more than 1.1 million vegetation plots and 26,632 plant species with trait information. Although we found a strong filtering of 17 functional traits, similar climate and soil conditions support communities differing greatly in mean trait values. The two main community trait axes that capture half of the global trait variation (plant stature and resource acquisitiveness) reflect the trade-offs at the species level but are weakly associated with climate and soil conditions at the global scale. Similarly, within-plot trait variation does not vary systematically with macro-environment. Our results indicate that, at fine spatial grain, macro-environmental drivers are much less important for functional trait composition than has been assumed from floristic analyses restricted to co-occurrence in large grid cells. Instead, trait combinations seem to be predominantly filtered by local-scale factors such as disturbance, fine-scale soil conditions, niche partitioning and biotic interactions.

Inflammation-induced IgA + cells dismantle anti-liver cancer immunity

Abstract: The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied by accumulation of liver-resident immunoglobulin-A-producing (IgA+) cells. These cells also express programmed death ligand 1 (PD-L1) and interleukin-10, and directly suppress liver cytotoxic CD8+ T lymphocytes, which prevent emergence of hepatocellular carcinoma and express a limited repertoire of T-cell receptors against tumour-associated antigens. Whereas CD8+ T-cell ablation accelerates hepatocellular carcinoma, genetic or pharmacological interference with IgA+ cell generation attenuates liver carcinogenesis and induces cytotoxic T-lymphocyte-mediated regression of established hepatocellular carcinoma. These findings establish the importance of inflammation-induced suppression of cytotoxic CD8+ T-lymphocyte activation as a tumour-promoting mechanism.