University of Adelaide

About: University of Adelaide is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 27251 authors who have published 79167 publications receiving 2671128 citations. The organization is also known as: The University of Adelaide & Adelaide University.

Building Up a Picture of the Electrocatalytic Nitrogen Reduction Activity of Transition Metal Single-Atom Catalysts.

Abstract: The lack of chemical understanding and efficient catalysts impedes the development of electrocatalytic nitrogen reduction reaction (eNRR) for ammonia production. In this work, we employed density functional theory calculations to build up a picture (activity trends, electronic origins, and design strategies) of single-atom catalysts (SACs) supported on nitrogen-doped carbons as eNRR electrocatalysts. To construct such a picture, this work presents systematic studies of the eNRR activity of SACs covering 20 different transition metal (TM) centers coordinated by nitrogen atoms contained in three types of nitrogen-doped carbon substrates, which gives 60 SACs. Our study shows that the intrinsic activity trends could be established on the basis of the nitrogen adatom adsorption energy (Δ EN*). Furthermore, the influence of metal and support (ligands) on Δ EN* proved to be related to the bonding/antibonding orbital population and regulating the scaling relations for adsorption of intermediates, respectively. Accordingly, a two-step strategy is proposed for improving the eNNR activity of TM-SACs, which involves the following: (i) selection of the most promising family of SACs (g-C3N4 supported SACs as predicted in this work) and (ii) further improvement of the activity of the best candidate in the aforementioned family via tuning the adsorption strength of the key intermediates. Also, the stability of N-doped carbon supports and their selectivity in comparison to the competing hydrogen evolution need to be taken into consideration for screening the durable and efficient candidates. Finally, an effective strategy for designing active, stable, and selective SACs based on the mechanistic insights is elaborated to guide future eNRR studies.

Sotorasib for Lung Cancers with KRAS p.G12C Mutation.

Abstract: Background Sotorasib showed anticancer activity in patients with KRAS p.G12C–mutated advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was observed i...

Unprecedented disruption of lives and work: Health, distress and life satisfaction of working adults in China one month into the COVID-19 outbreak.

Abstract: We assess the health and wellbeing of normal adults living and working after one month of confinement to contain the COVID-19 outbreak in China. On Feb 20-21, 2020, we surveyed 369 adults in 64 cities in China that varied in their rates of confirmed coronavirus cases on their health conditions, distress and life satisfaction. 27% of the participants worked at the office, 38% resorted to working from home, and 25% stopped working due to the outbreak. Those who stopped working reported worse mental and physical health conditions as well as distress. The severity of COVID-19 in an individual's home city predicts their life satisfaction, and this relationship is contingent upon individuals' existing chronic health issues and their hours of exercise. Our evidence supports the need to pay attention to the health of people who were not infected by the virus, especially for people who stopped working during the outbreak. Our results highlight that physically active people might be more susceptible to wellbeing issues during the lockdown. Policymakers who are considering introducing restrictive measures to contain COVID-19 may benefit from understanding such health and wellbeing implications.

A Prospective Study of Sudden Cardiac Death among Children and Young Adults

Abstract: BackgroundSudden cardiac death among children and young adults is a devastating event. We performed a prospective, population-based, clinical and genetic study of sudden cardiac death among children and young adults. MethodsWe prospectively collected clinical, demographic, and autopsy information on all cases of sudden cardiac death among children and young adults 1 to 35 years of age in Australia and New Zealand from 2010 through 2012. In cases that had no cause identified after a comprehensive autopsy that included toxicologic and histologic studies (unexplained sudden cardiac death), at least 59 cardiac genes were analyzed for a clinically relevant cardiac gene mutation. ResultsA total of 490 cases of sudden cardiac death were identified. The annual incidence was 1.3 cases per 100,000 persons 1 to 35 years of age; 72% of the cases involved boys or young men. Persons 31 to 35 years of age had the highest incidence of sudden cardiac death (3.2 cases per 100,000 persons per year), and persons 16 to 20 yea...