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Institution

University of Adelaide

EducationAdelaide, South Australia, Australia
About: University of Adelaide is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 27251 authors who have published 79167 publications receiving 2671128 citations. The organization is also known as: The University of Adelaide & Adelaide University.


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Journal ArticleDOI
20 Nov 2013-JAMA
TL;DR: In this study, weight reduction with intensive risk factor management resulted in a reduction in atrial fibrillation symptom burden and severity and in beneficial cardiac remodeling, and these findings support therapy directed at weight and risk factors in the management of atrial Fibrillation.
Abstract: Importance Obesity is a risk factor for atrial fibrillation. Whether weight reduction and cardiometabolic risk factor management can reduce the burden of atrial fibrillation is not known. Objective To determine the effect of weight reduction and management of cardiometabolic risk factors on atrial fibrillation burden and cardiac structure. Design, Setting, and Patients Single-center, partially blinded, randomized controlled study conducted between June 2010 and December 2011 in Adelaide, Australia, among overweight and obese ambulatory patients (N = 150) with symptomatic atrial fibrillation. Patients underwent a median of 15 months of follow-up. Interventions Patients were randomized to weight management (intervention) or general lifestyle advice (control). Both groups underwent intensive management of cardiometabolic risk factors. Main Outcomes and Measures The primary outcomes were Atrial Fibrillation Severity Scale scores: symptom burden and symptom severity. Scores were measured every 3 months from baseline to 15 months. Secondary outcomes performed at baseline and 12 months were total atrial fibrillation episodes and cumulative duration measured by 7-day Holter, echocardiographic left atrial area, and interventricular septal thickness. Results Of 248 patients screened, 150 were randomized (75 per group) and underwent follow-up. The intervention group showed a significantly greater reduction, compared with the control group, in weight (14.3 and 3.6 kg, respectively; P P P P = .01), and cumulative duration (692-minute decline and 419-minute increase, P = .002). Additionally, there was a reduction in interventricular septal thickness in the intervention and control groups (1.1 and 0.6 mm, P = .02) and left atrial area (3.5 and 1.9 cm 2 , P = .02). Conclusions and Relevance In this study, weight reduction with intensive risk factor management resulted in a reduction in atrial fibrillation symptom burden and severity and in beneficial cardiac remodeling. These findings support therapy directed at weight and risk factors in the management of atrial fibrillation. Trial Registration anzctr.org.au Identifier:ACTRN12610000497000

568 citations

Posted Content
TL;DR: Nearly 50% COVID-19 patients could not reach obvious clinical and radiological remission within 10 days after hospitalization, and the patients with male sex, anorexia and no fever on admission predicted poor efficacy.
Abstract: South Australia is presently in the throes of major changes to its regulatory system governing land use, development of land and the development of planning policy against which development assessment decisions are to be made. Eventually the planning and development control system established under the Development Act 1993 (SA) will be replaced by a new system implemented by the Planning, Development and Infrastructure Act 2016 (SA) (the new Act).

568 citations

Posted ContentDOI
Arang Rhie1, Shane A. McCarthy2, Olivier Fedrigo3, Joana Damas4, Giulio Formenti3, Sergey Koren1, Marcela Uliano-Silva2, William Chow2, Arkarachai Fungtammasan, Gregory Gedman3, Lindsey J. Cantin3, Françoise Thibaud-Nissen1, Leanne Haggerty5, Chul Hee Lee6, Byung June Ko6, J. H. Kim6, Iliana Bista2, Michelle Smith2, Bettina Haase3, Jacquelyn Mountcastle3, Sylke Winkler7, Sadye Paez3, Jason T. Howard8, Sonja C. Vernes7, Tanya M. Lama9, Frank Grützner10, Wesley C. Warren11, Christopher N. Balakrishnan12, Dave W Burt13, Jimin George14, Matthew T. Biegler3, David Iorns15, Andrew Digby, Daryl Eason, Taylor Edwards16, Mark Wilkinson17, George F. Turner18, Axel Meyer19, Andreas F. Kautt19, Paolo Franchini19, H. William Detrich20, Hannes Svardal21, Maximilian Wagner22, Gavin J. P. Naylor23, Martin Pippel7, Milan Malinsky2, Mark Mooney, Maria Simbirsky, Brett T. Hannigan, Trevor Pesout24, Marlys L. Houck, Ann C Misuraca, Sarah B. Kingan25, Richard Hall25, Zev N. Kronenberg25, Jonas Korlach25, Ivan Sović25, Christopher Dunn25, Zemin Ning2, Alex Hastie, Joyce V. Lee, Siddarth Selvaraj, Richard E. Green24, Nicholas H. Putnam, Jay Ghurye26, Erik Garrison24, Ying Sims2, Joanna Collins2, Sarah Pelan2, James Torrance2, Alan Tracey2, Jonathan Wood2, Dengfeng Guan27, Sarah E. London28, David F. Clayton14, Claudio V. Mello29, Samantha R. Friedrich29, Peter V. Lovell29, Ekaterina Osipova7, Farooq O. Al-Ajli30, Simona Secomandi31, Heebal Kim6, Constantina Theofanopoulou3, Yang Zhou32, Robert S. Harris33, Kateryna D. Makova33, Paul Medvedev33, Jinna Hoffman1, Patrick Masterson1, Karen Clark1, Fergal J. Martin5, Kevin L. Howe5, Paul Flicek5, Brian P. Walenz1, Woori Kwak, Hiram Clawson24, Mark Diekhans24, Luis R Nassar24, Benedict Paten24, Robert H. S. Kraus19, Harris A. Lewin4, Andrew J. Crawford34, M. Thomas P. Gilbert32, Guojie Zhang32, Byrappa Venkatesh35, Robert W. Murphy36, Klaus-Peter Koepfli37, Beth Shapiro24, Warren E. Johnson37, Federica Di Palma38, Tomas Marques-Bonet39, Emma C. Teeling40, Tandy Warnow41, Jennifer A. Marshall Graves42, Oliver A. Ryder43, David Haussler24, Stephen J. O'Brien44, Kerstin Howe2, Eugene W. Myers45, Richard Durbin2, Adam M. Phillippy1, Erich D. Jarvis3 
23 May 2020-bioRxiv
TL;DR: The Vertebrate Genomes Project is embarked on, an effort to generate high-quality, complete reference genomes for all ~70,000 extant vertebrate species and help enable a new era of discovery across the life sciences.
Abstract: High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. However, such assemblies are only available for a few non-microbial species. To address this issue, the international Genome 10K (G10K) consortium has worked over a five-year period to evaluate and develop cost-effective methods for assembling the most accurate and complete reference genomes to date. Here we summarize these developments, introduce a set of quality standards, and present lessons learned from sequencing and assembling 16 species representing major vertebrate lineages (mammals, birds, reptiles, amphibians, teleost fishes and cartilaginous fishes). We confirm that long-read sequencing technologies are essential for maximizing genome quality and that unresolved complex repeats and haplotype heterozygosity are major sources of error in assemblies. Our new assemblies identify and correct substantial errors in some of the best historical reference genomes. Adopting these lessons, we have embarked on the Vertebrate Genomes Project (VGP), an effort to generate high-quality, complete reference genomes for all ~70,000 extant vertebrate species and help enable a new era of discovery across the life sciences.

567 citations

Journal ArticleDOI
TL;DR: Soil water dynamics, soil structural stability, solubility of compounds in relation to pH and pE and nutrient and water movement all play vital roles in the selection and development of plants tolerant to salinity.
Abstract: Salts can be deposited in the soil from wind and rain, as well as through the weathering of rocks. These processes, combined with the influence of climatic and landscape features and the effects of human activities, determine where salt accumulates in the landscape. When the accumulated salt in soil layers is above a level that adversely affects crop production, choosing salt-tolerant crops and managing soil salinity are important strategies to boost agricultural economy. Worldwide, more than 800 million hectares of soils are salt-affected, with a range of soils defined as saline, acidic–saline, alkaline–saline, acidic saline–sodic, saline–sodic, alkaline saline–sodic, sodic, acidic–sodic and alkaline–sodic. The types of salinity based on soil and groundwater processes are groundwater-associated salinity (dryland salinity), transient salinity (dry saline land) and irrigation salinity. This short review deals with the soil processes in the field that determine the interactions between root-zone environments and plant responses to increased osmotic pressure or specific ion concentrations. Soil water dynamics, soil structural stability, solubility of compounds in relation to pH and pE and nutrient and water movement all play vital roles in the selection and development of plants tolerant to salinity.

567 citations

Journal ArticleDOI
TL;DR: It is proposed that adult human DPSCs provide a readily accessible source of exogenous stem/precursor cells that have the potential for use in cell‐therapeutic paradigms to treat neurological disease.
Abstract: Human adult dental pulp stem cells (DPSCs) reside within the perivascular niche of dental pulp and are thought to originate from migrating cranial neural crest (CNC) cells. During embryonic development, CNC cells differentiate into a wide variety of cell types, including neurons of the peripheral nervous system. Previously, we have demonstrated that DPSCs derived from adult human third molar teeth differentiate into cell types reminiscent of CNC embryonic ontology. We hypothesized that DPSCs exposed to the appropriate environmental cues would differentiate into functionally active neurons. The data demonstrated that ex vivo-expanded human adult DPSCs responded to neuronal inductive conditions both in vitro and in vivo. Human adult DPSCs, but not human foreskin fibroblasts (HFFs), acquired a neuronal morphology, and expressed neuronal-specific markers at both the gene and protein levels. Culture-expanded DPSCs also exhibited the capacity to produce a sodium current consistent with functional neuronal cells when exposed to neuronal inductive media. Furthermore, the response of human DPSCs and HFFs to endogenous neuronal environmental cues was determined in vivo using an avian xenotransplantation assay. DPSCs expressed neuronal markers and acquired a neuronal morphology following transplantation into the mesencephalon of embryonic day-2 chicken embryo, whereas HFFs maintained a thin spindle fibroblastic morphology. We propose that adult human DPSCs provide a readily accessible source of exogenous stem/precursor cells that have the potential for use in cell-therapeutic paradigms to treat neurological disease.

567 citations


Authors

Showing all 27579 results

NameH-indexPapersCitations
Martin White1962038232387
Nicholas G. Martin1921770161952
David W. Johnson1602714140778
Nicholas J. Talley158157190197
Mark E. Cooper1581463124887
Xiang Zhang1541733117576
John E. Morley154137797021
Howard I. Scher151944101737
Christopher M. Dobson1501008105475
A. Artamonov1501858119791
Timothy P. Hughes14583191357
Christopher Hill1441562128098
Shi-Zhang Qiao14252380888
Paul Jackson141137293464
H. A. Neal1411903115480
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023127
2022597
20215,500
20205,342
20194,803
20184,443