Institution
University of Adelaide
Education•Adelaide, South Australia, Australia•
About: University of Adelaide is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 27251 authors who have published 79167 publications receiving 2671128 citations. The organization is also known as: The University of Adelaide & Adelaide University.
Topics: Population, Poison control, Pregnancy, Health care, Mental health
Papers published on a yearly basis
Papers
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TL;DR: It is shown that phosphorylation of sphingosine kinase 1 at Ser225 results not only in an increase in enzyme activity, but is also necessary for translocation of the enzyme from the cytosol to the plasma membrane.
Abstract: Sphingosine kinase 1 is an agonist-activated signalling enzyme that catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist-driven cellular responses, including stimulation of cell proliferation, inhibition of apoptosis and expression of inflammatory molecules. Although agonist-induced stimulation of sphingosine kinase activity is critical in a number of signalling pathways, nothing has been known of the molecular mechanism of this activation. Here we show that this activation results directly from phosphorylation of sphingosine kinase 1 at Ser225, and present several lines of evidence to show compellingly that the activating kinase is ERK1/2 or a close relative. Furthermore, we show that phosphorylation of sphingosine kinase 1 at Ser225 results not only in an increase in enzyme activity, but is also necessary for translocation of the enzyme from the cytosol to the plasma membrane. Thus, these studies have elucidated the mechanism of agonist-mediated sphingosine kinase activation, and represent a key finding in understanding the regulation of sphingosine kinase/sphingosine 1-phosphate-controlled signalling pathways.
523 citations
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TL;DR: In this Review, Weiser, Ferreira and Paton summarize the mechanisms that allow pneumococci to transmit and progress from colonizer to pathogen.
Abstract: Streptococcus pneumoniae has a complex relationship with its obligate human host. On the one hand, the pneumococci are highly adapted commensals, and their main reservoir on the mucosal surface of the upper airways of carriers enables transmission. On the other hand, they can cause severe disease when bacterial and host factors allow them to invade essentially sterile sites, such as the middle ear spaces, lungs, bloodstream and meninges. Transmission, colonization and invasion depend on the remarkable ability of S. pneumoniae to evade or take advantage of the host inflammatory and immune responses. The different stages of pneumococcal carriage and disease have been investigated in detail in animal models and, more recently, in experimental human infection. Furthermore, widespread vaccination and the resulting immune pressure have shed light on pneumococcal population dynamics and pathogenesis. Here, we review the mechanistic insights provided by these studies on the multiple and varied interactions of the pneumococcus and its host.
523 citations
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01 Jan 1988-International Journal of Radiation Applications and Instrumentation. Part D. Nuclear Tracks and Radiation Measurements
TL;DR: In this paper, the cosmic ray dose as a function of depth has been measured to a depth of 450 g cm-2 in limestone and an expression that extends this to any depth of likely interest.
522 citations
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TL;DR: This report provides national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.
522 citations
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TL;DR: In this article, the effect of the addition of steel and polypropylene fibers on the mechanical and some durability properties of high-strength concrete (HSC) was investigated, and the results showed that the incorporation of 1% steel fiber significantly enhanced the splitting tensile strength and flexural strength of concrete.
521 citations
Authors
Showing all 27579 results
Name | H-index | Papers | Citations |
---|---|---|---|
Martin White | 196 | 2038 | 232387 |
Nicholas G. Martin | 192 | 1770 | 161952 |
David W. Johnson | 160 | 2714 | 140778 |
Nicholas J. Talley | 158 | 1571 | 90197 |
Mark E. Cooper | 158 | 1463 | 124887 |
Xiang Zhang | 154 | 1733 | 117576 |
John E. Morley | 154 | 1377 | 97021 |
Howard I. Scher | 151 | 944 | 101737 |
Christopher M. Dobson | 150 | 1008 | 105475 |
A. Artamonov | 150 | 1858 | 119791 |
Timothy P. Hughes | 145 | 831 | 91357 |
Christopher Hill | 144 | 1562 | 128098 |
Shi-Zhang Qiao | 142 | 523 | 80888 |
Paul Jackson | 141 | 1372 | 93464 |
H. A. Neal | 141 | 1903 | 115480 |