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Institution

University of Alabama at Birmingham

EducationBirmingham, Alabama, United States
About: University of Alabama at Birmingham is a education organization based out in Birmingham, Alabama, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 38523 authors who have published 86775 publications receiving 3930642 citations. The organization is also known as: UAB & The University of Alabama at Birmingham.


Papers
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Journal ArticleDOI
TL;DR: Investigation of plausible contributors to the obesity epidemic beyond the two most commonly suggested factors, reduced physical activity and food marketing practices found supportive evidence that in many cases is as compelling as the evidence for more commonly discussed putative explanations.
Abstract: Putative contributors to the secular increase in obesity: exploring the roads less traveled

628 citations

Journal ArticleDOI
Roby Joehanes, Allan C. Just1, Riccardo E. Marioni2, Luke C. Pilling1, Lindsay M. Reynolds1, Pooja R. Mandaviya3, Weihua Guan, Tao Xu2, Cathy E. Elks2, Stella Aslibekyan1, Hortensia Moreno-Macías4, Jennifer A. Smith3, Jennifer A. Brody3, Radhika Dhingra3, Paul Yousefi5, James S. Pankow, Sonja Kunze, Sonia Shah6, Allan F. McRae6, Kurt Lohman6, Jin Sha7, Jin Sha8, Devin Absher7, Luigi Ferrucci7, Wei Zhao9, Ellen W. Demerath8, Jan Bressler6, Megan L. Grove7, Tianxiao Huan10, Tianxiao Huan9, Chunyu Liu5, Chunyu Liu2, Chunyu Liu3, Michael M. Mendelson, Chen Yao1, Douglas P. Kiel4, Annette Peters11, Rui Wang-Sattler, Peter M. Visscher12, Naomi R. Wray, John M. Starr13, Jingzhong Ding3, Carlos J. Rodriguez1, Nicholas J. Wareham, Marguerite R. Irvin2, Degui Zhi2, Myrto Barrdahl2, Paolo Vineis1, Srikant Ambatipudi, André G. Uitterlinden2, Albert Hofman14, Joel Schwartz10, Elena Colicino15, Lifang Hou3, Pantel S. Vokonas2, D. Hernandez16, Andrew B. Singleton, Stefania Bandinelli17, Stephen Turner, Erin B. Ware, Alicia K. Smith, Torsten Klengel18, Elisabeth B. Binder19, Bruce M. Psaty20, Kent D. Taylor, Sina A. Gharib1, Brenton R. Swenson21, Liming Liang22, Dawn L. DeMeo, George T. O'Connor, Zdenko Herceg1, Kerry J. Ressler23, Karen N. Conneely11, N. Sotoodehnia24, Sharon L.R. Kardia2, David Melzer17, Andrea A. Baccarelli1, Joyce B. J. van Meurs1, Isabelle Romieu3, Donna K. Arnett, Ken K. Ong, Yongmei Liu19, M. Waldenberger25, Ian J. Deary1, Myriam Fornage26, Daniel Levy, Stephanie J. London11 
TL;DR: Cigarette smoking has a broad impact on genome-wide methylation that, at many loci, persists many years aftersmoking cessation, indicating a pattern of persistent altered methylation, with attenuation, after smoking cessation.
Abstract: Background —DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers, osteoporosis, lung, and cardiovascular disorders. Methods and Results —To comprehensively determine the association between cigarette smoking and DNA methylation, we conducted a meta-analysis of genome-wide DNA methylation assessed using the Illumina BeadChip 450K array on 15,907 blood derived DNA samples from participants in 16 cohorts (including 2,433 current, 6,518 former, and 6,956 never smokers). Comparing current versus never smokers, 2,623 CpG sites (CpGs), annotated to 1,405 genes, were statistically significantly differentially methylated at Bonferroni threshold of p<1×10-7 (18,760 CpGs at False Discovery Rate (FDR)<0.05). Genes annotated to these CpGs were enriched for associations with several smoking-related traits in genome-wide studies including pulmonary function, cancers, inflammatory diseases and heart disease. Comparing former versus never smokers, 185 of the CpGs that differed between current and never smokers were significant p<1×10-7 (2,623 CpGs at FDR<0.05), indicating a pattern of persistent altered methylation, with attenuation, after smoking cessation. Transcriptomic integration identified effects on gene expression at many differentially methylated CpGs. Conclusions —Cigarette smoking has a broad impact on genome-wide methylation that, at many loci, persists many years after smoking cessation. Many of the differentially methylated genes were novel genes with respect to biologic effects of smoking, and might represent therapeutic targets for prevention or treatment of tobacco-related diseases. Methylation at these sites could also serve as sensitive and stable biomarkers of lifetime exposure to tobacco smoke.

628 citations

Journal ArticleDOI
TL;DR: In this paper, a single sample was obtained per patient and was evaluated using an assay to detect serum β-D-glucan derived from fungal cell walls (range, 0 to > 7000 pg/mL).
Abstract: BACKGROUND Measurement of (1-->3)-beta-D-Glucan (BG) has emerged as an adjunct diagnostic strategy for invasive fungal infections (IFI). METHODS Subjects at 6 clinical sites in the United States were enrolled as either fungal infection-negative subjects (n = 170) or subjects with proven or probable IFI according to European Organization for the Research and Treatment of Cancer/Mycoses Study Group criteria (n = 163). A central laboratory and 4 sites performed assays. A single sample was obtained per patient and was evaluated using an assay to detect serum BG derived from fungal cell walls (range, 0 to > 7000 pg/mL). RESULTS At a cutoff of 60 pg/mL, the sensitivity and specificity of the assay were 69.9% and 87.1%, respectively, with a positive predictive value (PPV) of 83.8% and a negative predictive value (NPV) of 75.1%. At a cutoff value of 80 pg/mL, the sensitivity and specificity were 64.4% and 92.4%, respectively, with a PPV of 89% and an NPV of 73%. Of the 107 patients with proven candidiasis, 81.3% had positive results at a cutoff value of 60 pg/mL, and 77.6% had positive results at a cutoff value of 80 pg/mL. Of the 10 patients with aspergillosis, 80% had positive results at cutoff values of 60 and 80 pg/mL. The 3 subjects diagnosed with Fusarium species had positive results at a cutoff value of 60 pg/mL. Patients infected with Mucor or Rhizopus species (both of which lack BG) had negative results at both cutoff values, and of the 12 patients with Cryptococcus infection, 3 had positive results at a cutoff value of 60 pg/mL, and 2 had positive results at a cutoff value of 80 pg/mL. Of the subjects with proven positive results who were receiving antifungal therapy (n = 118), 72.9% had results positive for BG at a cutoff value of 60 pg/mL, and 69.5% had results positive for BG at a cutoff value of 80 pg/mL. The interlaboratory sample test r2 was 0.93. CONCLUSION Reproducible assay results with high specificity and high PPV in a multicenter setting demonstrate that use of an assay to detect serum BG derived from fungal cell walls is a useful diagnostic adjunct for IFI.

626 citations

Journal ArticleDOI
TL;DR: It is concluded that oxidation of LDL by artery wall cells requires seeding molecules that include HPODE and HPETE and normal HDL and its components can remove or inhibit the activity of lipids in freshly isolated LDL that are required for oxidation by human arteries wall cells.

626 citations

Journal ArticleDOI
TL;DR: Preclinical results indicate that targeted inhibition of class I HDAC isoforms is a promising avenue for treating the cognitive deficits associated with early stage AD.

625 citations


Authors

Showing all 38940 results

NameH-indexPapersCitations
Rudolf Jaenisch206606178436
Joel Schwartz1831149109985
Tadamitsu Kishimoto1811067130860
Jasvinder A. Singh1762382223370
Gregg L. Semenza168502130316
David R. Jacobs1651262113892
Hua Zhang1631503116769
David R. Holmes1611624114187
David Cella1561258106402
Elaine S. Jaffe156828112412
Michael A. Matthay15199898687
Lawrence Corey14677378105
Barton F. Haynes14491179014
Douglas D. Richman14263382806
Kjell Fuxe142147989846
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023168
2022530
20215,327
20205,028
20194,402
20184,083