Institution
University of Alabama at Birmingham
Education•Birmingham, Alabama, United States•
About: University of Alabama at Birmingham is a education organization based out in Birmingham, Alabama, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 38523 authors who have published 86775 publications receiving 3930642 citations. The organization is also known as: UAB & The University of Alabama at Birmingham.
Topics: Population, Medicine, Cancer, Poison control, Health care
Papers published on a yearly basis
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TL;DR: A critical role is demonstrated for AKT-mediated induction of Runx2 in oxidative stress-induced VSMC calcification, which promotes a phenotypic switch of VSMC from contractile to osteogenic phenotype.
553 citations
University of Alabama at Birmingham1, National Institutes of Health2, George Washington University3, University of Utah4, University of Tennessee Health Science Center5, Case Western Reserve University6, Ohio State University7, Thomas Jefferson University8, Drexel University9, Wayne State University10, University of Texas at Dallas11, Wake Forest University12, University of North Carolina at Chapel Hill13, University of Texas at Austin14, Columbia University15, Brown University16, University of Cincinnati17, University of Chicago18, University of Miami19, Northwestern University20, University of Texas Medical Branch21, University of Texas at San Antonio22, University of Pittsburgh23
TL;DR: Fetal exposure to magnesium sulfate before anticipated early preterm delivery did not reduce the combined risk of moderate or severe cerebral palsy or death, although the rate of cerebral palsies was reduced among survivors.
Abstract: BACKGROUND Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy METHODS In this multicenter, placebo-controlled, double-blind trial, we randomly assigned women at imminent risk for delivery between 24 and 31 weeks of gestation to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour, or matching placebo The primary outcome was the composite of stillbirth or infant death by 1 year of corrected age or moderate or severe cerebral palsy at or beyond 2 years of corrected age RESULTS A total of 2241 women underwent randomization The baseline characteristics were similar in the two groups Follow-up was achieved for 956% of the children The rate of the primary outcome was not significantly different in the magnesium sulfate group and the placebo group (113% and 117%, respectively; relative risk, 097; 95% confidence interval [CI], 077 to 123) However, in a prespecified secondary analysis, moderate or severe cerebral palsy occurred significantly less frequently in the magnesium sulfate group (19% vs 35%; relative risk, 055; 95% CI, 032 to 095) The risk of death did not differ significantly between the groups (95% vs 85%; relative risk, 112; 95% CI, 085 to 147) No woman had a life-threatening event CONCLUSIONS Fetal exposure to magnesium sulfate before anticipated early preterm delivery did not reduce the combined risk of moderate or severe cerebral palsy or death, although the rate of cerebral palsy was reduced among survivors (ClinicalTrialsgov number, NCT00014989)
553 citations
Haidong Wang1, Amanuel Alemu Abajobir2, Kalkidan Hassen Abate3, Cristiana Abbafati4 +781 more•Institutions (41)
TL;DR: Age-specific and sex-specific all-cause mortality between 1970 and 2016 is estimated for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016 to identify countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone.
553 citations
TL;DR: This review attempts to provide a critical description of some of the most common approaches to quantification of nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite, with attention to key issues that may influence the utility of a particular assay when adapted for use in vascular cells and tissues.
Abstract: The evanescent nature of reactive oxygen and nitrogen species, the multiple cellular mechanisms evolved to maintain these substances at low (submicromolar) concentrations within the vascular system, and the often multifaceted nature of their reactivities have made measurement of these compounds within the vasculature problematic. This review attempts to provide a critical description of some of the most common approaches to quantification of nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite, with attention to key issues that may influence the utility of a particular assay when adapted for use in vascular cells and tissues.
552 citations
University of Copenhagen1, University of Bergen2, University of New Mexico3, Del Rosario University4, Merck & Co.5, Indiana University6, University of Washington7, Boston Children's Hospital8, Cayetano Heredia University9, Emory University10, University of Melbourne11, Royal Women's Hospital12, Medical University of Vienna13, Karolinska Institutet14, University of Hong Kong15, Georgia Regents University16, University of Helsinki17, Lund University18, University of Alabama at Birmingham19, Johns Hopkins University20, Medical University of Warsaw21, Duke University22, Ludwig Institute for Cancer Research23
TL;DR: High-coverage HPV vaccination programs among adolescents and young women may result in a rapid reduction of genital warts, cervical cytological abnormalities, and diagnostic and therapeutic procedures and in the longer term, substantial reductions in the rates of cervical, vulvar, and vaginal cancers may follow.
Abstract: Results The average follow-up was 3.6 years (maximum of 4.9 years). In the population that was negative to 14 HPV types, vaccination was up to 100% effective in reducing the risk of HPV16/18-related high-grade cervical, vulvar, and vaginal lesions and of HPV6/11-related genital warts. In the intention-to-treat group, vaccination also statistically significantly reduced the risk of any high-grade cervical lesions (19.0% reduction; rate vaccine = 1.43, rate placebo = 1.76, difference = 0.33, 95% confidence interval [CI] = 0.13 to 0.54), vulvar and vaginal lesions (50.7% reduction; rate vaccine = 0.10, rate placebo = 0.20, difference = 0.10, 95% CI = 0.04 to 0.16), genital warts (62.0% reduction; rate vaccine = 0.44, rate placebo = 1.17, difference = 0.72, 95% CI = 0.58 to 0.87), Pap abnormalities (11.3% reduction; rate vaccine = 10.36, rate placebo = 11.68, difference = 1.32, 95% CI = 0.74 to 1.90), and cervical definitive therapy (23.0% reduction; rate vaccine = 1.97, rate placebo = 2.56, difference = 0.59, 95% CI = 0.35 to 0.83), irrespective of causal HPV type. Conclusions High-coverage HPV vaccination programs among adolescents and young women may result in a rapid reduction of genital warts, cervical cytological abnormalities, and diagnostic and therapeutic procedures. In the longer term, substantial reductions in the rates of cervical, vulvar, and vaginal cancers may follow.
550 citations
Authors
Showing all 38940 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Rudolf Jaenisch | 206 | 606 | 178436 |
| Joel Schwartz | 183 | 1149 | 109985 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Jasvinder A. Singh | 176 | 2382 | 223370 |
| Gregg L. Semenza | 168 | 502 | 130316 |
| David R. Jacobs | 165 | 1262 | 113892 |
| Hua Zhang | 163 | 1503 | 116769 |
| David R. Holmes | 161 | 1624 | 114187 |
| David Cella | 156 | 1258 | 106402 |
| Elaine S. Jaffe | 156 | 828 | 112412 |
| Michael A. Matthay | 151 | 998 | 98687 |
| Lawrence Corey | 146 | 773 | 78105 |
| Barton F. Haynes | 144 | 911 | 79014 |
| Douglas D. Richman | 142 | 633 | 82806 |
| Kjell Fuxe | 142 | 1479 | 89846 |