Institution
University of Alabama
Education•Tuscaloosa, Alabama, United States•
About: University of Alabama is a education organization based out in Tuscaloosa, Alabama, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 27323 authors who have published 48609 publications receiving 1565337 citations. The organization is also known as: Alabama & Bama.
Topics: Population, Poison control, Large Hadron Collider, Galaxy, Health care
Papers published on a yearly basis
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TL;DR: 13C isotopic tracer data previously obtained by 13C nuclear magnetic resonance in the human brain in vivo were analyzed using a mathematical model to determine metabolic rates in a region of the human neocortex and the calculated values were found to be unchanged as long as the assumptions remained near reported physiological values.
Abstract: 13C isotopic tracer data previously obtained by 13C nuclear magnetic resonance in the human brain in vivo were analyzed using a mathematical model to determine metabolic rates in a region of the human neocortex. The tricarboxylic acid (TCA) cycle rate was 0.73 ± 0.19 μmol min-1 g-1 (mean ± SD; n = 4). The standard deviation reflects primarily intersubject variation, since individual uncertainties were low. The rate of α- ketoglutarate/glutamate exchange was 57 ± 26 μmol min-1 g-1 (n = 3), which is much greater than the TCA cycle rate; the high rate indicates that α-ketoglutarate and glutamate are in rapid exchange and can be treated as a single combined kinetic pool. The rate of synthesis of glutamine from glutamate was 0.47 μmol min-1 g-1 (n = 4), with 95% confidence limits of 0.139 and 3.094 μmol min-1 g-1; individual uncertainties were biased heavily toward high synthesis rates. From the TCA cycle rate the brain oxygen consumption was estimated to be 2.14 ± 0.48 μmol min-1 g-1 (5.07 ± 1.14 ml 100 g-1 min-1; n = 4), and the rate of brain glucose consumption was calculated to be 0.37 ± 0.08 μmol min-1 g-1 (n = 4). The sensitivity of the model to the assumptions made was evaluated, and the calculated values were found to be unchanged as long as the assumptions remained near reported physiological values.
307 citations
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Northwestern University1, University of Chicago2, University of Oxford3, University of Warwick4, Hammersmith Hospital5, Broad Institute6, University of Utah7, National and Kapodistrian University of Athens8, Aristotle University of Thessaloniki9, Cedars-Sinai Medical Center10, Georgia Regents University11, Medical College of Wisconsin12, Texas Biomedical Research Institute13, Karolinska Institutet14, Pennsylvania State University15, University of Colorado Denver16, Duke University17, Stanford University18, University of Pennsylvania19, University of Alabama20, University of Texas Health Science Center at San Antonio21, University of Texas Southwestern Medical Center22, Baylor College of Medicine23, University of Vermont24, University of Michigan25, Wayne State University26, National Institutes of Health27, University of Pittsburgh28, University of California, San Francisco29, University of Virginia30, Yale University31, Virginia Commonwealth University32, Rutgers University33, State University of New York Upstate Medical University34, Carolinas Medical Center35
TL;DR: Common genetic susceptibility loci in European ancestry women for the National Institutes of Health PCOS phenotype are identified, which confers the highest risk for metabolic morbidities, as well as reproductive hormone levels, and implicate neuroendocrine changes in disease pathogenesis.
Abstract: Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating hormone secretion, insulin resistance and developmental exposure to androgens are hypothesized to play a causal role in PCOS. Here we map common genetic susceptibility loci in European ancestry women for the National Institutes of Health PCOS phenotype, which confers the highest risk for metabolic morbidities, as well as reproductive hormone levels. Three loci reach genome-wide significance in the case–control meta-analysis, two novel loci mapping to chr 8p32.1 and chr 11p14.1, and a chr 9q22.32 locus previously found in Chinese PCOS. The same chr 11p14.1 SNP, rs11031006, in the region of the follicle-stimulating hormone B polypeptide (FSHB) gene strongly associates with PCOS diagnosis and luteinizing hormone levels. These findings implicate neuroendocrine changes in disease pathogenesis.
306 citations
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University of California, San Francisco1, University of Texas MD Anderson Cancer Center2, University of North Carolina at Chapel Hill3, University of Pennsylvania4, Lawrence Berkeley National Laboratory5, Oregon Health & Science University6, Boston University7, Memorial Sloan Kettering Cancer Center8, University of Alabama9, Albert Einstein College of Medicine10, University of Southern California11, University of Washington12, Georgetown University13, University of Chicago14, Yale University15, New York University16
TL;DR: Categorization of breast cancer by molecular signatures enhanced the ability of pCR to predict improvement in RFS compared to the population as a whole, and molecular markers improve prediction of RFS by identifying additional patients with excellent prognosis within the no pCR group.
Abstract: Neoadjuvant chemotherapy for breast cancer allows individual tumor response to be assessed depending on molecular subtype, and to judge the impact of response to therapy on recurrence-free survival (RFS). The multicenter I-SPY 1 TRIAL evaluated patients with ≥ 3 cm tumors by using early imaging and molecular signatures, with outcomes of pathologic complete response (pCR) and RFS. The current analysis was performed using data from patients who had molecular profiles and did not receive trastuzumab. The various molecular classifiers tested were highly correlated. Categorization of breast cancer by molecular signatures enhanced the ability of pCR to predict improvement in RFS compared to the population as a whole. In multivariate analysis, the molecular signatures that added to the ability of HR and HER2 receptors, clinical stage, and pCR in predicting RFS included 70-gene signature, wound healing signature, p53 mutation signature, and PAM50 risk of recurrence. The low risk signatures were associated with significantly better prognosis, and also identified additional patients with a good prognosis within the no pCR group, primarily in the hormone receptor positive, HER-2 negative subgroup. The I-SPY 1 population is enriched for tumors with a poor prognosis but is still heterogeneous in terms of rates of pCR and RFS. The ability of pCR to predict RFS is better by subset than it is for the whole group. Molecular markers improve prediction of RFS by identifying additional patients with excellent prognosis within the no pCR group.
306 citations
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TL;DR: In this article, a combined three-flavor analysis of solar and KamLAND data gives fit values for the oscillation parameters of tan2θ12=0.436+0.029−0.025, Δm221=7.53 + 0.18 − 0.002, and sin2πθ13=
Abstract: The recent long-term shutdown of Japanese nuclear reactors has resulted in a significantly reduced reactor ν¯e flux at KamLAND. This running condition provides a unique opportunity to confirm and constrain backgrounds for the reactor ν¯e oscillation analysis. The data set also has improved sensitivity for other ν¯e signals, in particular ν¯e’s produced in β-decays from U238 and Th232 within the Earth’s interior, whose energy spectrum overlaps with that of reactor ν¯e’s. Including constraints on θ13 from accelerator and short-baseline reactor neutrino experiments, a combined three-flavor analysis of solar and KamLAND data gives fit values for the oscillation parameters of tan2θ12=0.436+0.029−0.025, Δm221=7.53+0.18−0.18×10−5 eV2, and sin2θ13=0.023+0.002−0.002. Assuming a chondritic Th/U mass ratio, we obtain 116+28−27 ν¯e events from U238 and Th232, corresponding to a geo ν¯e flux of 3.4+0.8−0.8×106 cm−2 s−1 at the KamLAND location. We evaluate various bulk silicate Earth composition models using the observed geo ν¯e rate.
306 citations
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TL;DR: It is argued that while IT activities remain integral to the functional-level strategies of the firm, they also play several significant roles in business strategy, with substantial performance implications.
Abstract: Information technology matters to business success because it directly affects the mechanisms through which they create and capture value to earn a profit: IT is thus integral to a firm's business-level strategy. Much of the extant research on the IT/strategy relationship, however, inaccurately frames IT as only a functional-level strategy. This widespread under-appreciation of the business-level role of IT indicates a need for substantial retheorizing of its role in strategy and its complex and interdependent relationship with the mechanisms through which firms generate profit. Using a comprehensive framework of potential profit mechanisms, we argue that while IT activities remain integral to the functional-level strategies of the firm, they also play several significant roles in business strategy, with substantial performance implications. IT affects industry structure and the set of business-level strategic alternatives and value-creation opportunities that a firm may pursue. Along with complementary organizational changes, IT both enhances the firm's current (ordinary) capabilities and enables new (dynamic) capabilities, including the flexibility to focus on rapidly changing opportunities or to abandon losing initiatives while salvaging substantial asset value. Such digitally attributable capabilities also determine how much of this value, once created, can be captured by the firm--and how much will be dissipated through competition or through the power of value chain partners, the governance of which itself depends on IT. We explore these business-level strategic roles of IT and discuss several provocative implications and future research directions in the converging information systems and strategy domains.
306 citations
Authors
Showing all 27508 results
Name | H-index | Papers | Citations |
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Jasvinder A. Singh | 176 | 2382 | 223370 |
Hongfang Liu | 166 | 2356 | 156290 |
Ian J. Deary | 166 | 1795 | 114161 |
Yongsun Kim | 156 | 2588 | 145619 |
Dong-Chul Son | 138 | 1370 | 98686 |
Simon C. Watkins | 135 | 950 | 68358 |
Kenichi Hatakeyama | 134 | 1731 | 102438 |
Conor Henderson | 133 | 1387 | 88725 |
Peter R Hobson | 133 | 1590 | 94257 |
Tulika Bose | 132 | 1285 | 88895 |
Helen F Heath | 132 | 1185 | 89466 |
James Rohlf | 131 | 1215 | 89436 |
Panos A Razis | 130 | 1287 | 90704 |
David B. Allison | 129 | 836 | 69697 |
Eduardo Marbán | 129 | 579 | 49586 |