University of Alabama

About: University of Alabama is a education organization based out in Tuscaloosa, Alabama, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 27323 authors who have published 48609 publications receiving 1565337 citations. The organization is also known as: Alabama & Bama.

Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae

Abstract: Pneumococcal surface protein A (PspA) has been shown previously to elicit antibodies protective against pneumococcal infection and to be necessary for full pneumococcal virulence in mice. The protein was originally defined by the two mouse monoclonal antibodies Xi64 and Xi126, which together recognized PspA on 14% of pneumococcal isolates. Some PspA molecules reacted with both antibodies, but most reacted with only one or the other. In the present study we demonstrated that PspA is produced by all pneumococci, confirming our hypothesis that there are variants of PspA which are not detected by Xi64 and Xi126. We produced a rabbit antiserum and five additional monoclonal antibodies specific for PspA for these studies. The rabbit antiserum reacted with each of 95 pneumococcal isolated tested, comprising 16 capsular serotypes. One or more of the seven monoclonal anti-PspA antibodies reacted with 95% (53 of 57) of pneumococcal isolates tested. The specificity of the monoclonal and polyclonal antibodies to PspA was confirmed in two ways: (i) by detection of molecules on wild-type pneumococci that are identical in molecular weight to those detected in Western blots (immunoblots) with Xi64 and Xi126 and (ii) by the use of mutants of Streptococcus pneumoniae that fail to produce PspA or that produce a truncated form of PspA. By using the seven monoclonal antibodies, we observed 31 PspA types among the 57 isolates. When the 53 strains reactive with the monoclonal antibodies were analyzed by capsular type as well as by serologic type and molecular weight of PspA, we observed 50 different clonotypes of pneumococci.

Extraction and validation of a new set of CMS pythia8 tunes from underlying-event measurements

Abstract: New sets of CMS underlying-event parameters (“tunes”) are presented for the pythia8 event generator. These tunes use the NNPDF3.1 parton distribution functions (PDFs) at leading (LO), next-to-leading (NLO), or next-to-next-to-leading (NNLO) orders in perturbative quantum chromodynamics, and the strong coupling evolution at LO or NLO. Measurements of charged-particle multiplicity and transverse momentum densities at various hadron collision energies are fit simultaneously to determine the parameters of the tunes. Comparisons of the predictions of the new tunes are provided for observables sensitive to the event shapes at LEP, global underlying event, soft multiparton interactions, and double-parton scattering contributions. In addition, comparisons are made for observables measured in various specific processes, such as multijet, Drell–Yan, and top quark-antiquark pair production including jet substructure observables. The simulation of the underlying event provided by the new tunes is interfaced to a higher-order matrix-element calculation. For the first time, predictions from pythia8 obtained with tunes based on NLO or NNLO PDFs are shown to reliably describe minimum-bias and underlying-event data with a similar level of agreement to predictions from tunes using LO PDF sets.

Galaxy Zoo: 'Hanny's Voorwerp', a quasar light echo?

Abstract: We report the discovery of an unusual object near the spiral galaxy IC 2497, discovered by visual inspection of the Sloan Digital Sky Survey (SDSS) as part of the Galaxy Zoo project. The object, known as Hanny’s Voorwerp, is bright in the SDSS g band due to unusually strong [O III]4959, 5007 emission lines. We present the results of the first targeted observations of the object in the optical, ultraviolet and X-ray, which show that the object contains highly ionized gas. Although the line ratios are similar to extended emission-line regions near luminous active galactic nucleus (AGN), the source of this ionization is not apparent. The emission-line properties, and lack of X-ray emission from IC 2497, suggest either a highly obscured AGN with a novel geometry arranged to allow photoionization of the object but not the galaxy’s own circumnuclear gas, or, as we argue, the first detection of a quasar light echo. In this case, either the luminosity of the central source has decreased dramatically or else the obscuration in the system has increased within 10 5 yr. This object may thus represent the first direct probe

Historical and Personality Correlates to the Violence Patterns of Juveniles Tried as Adults

Abstract: This study examined the utility of several personality indices for explaining variance in the frequency, variety, and situational correlates of past violence exhibited by imprisoned juveniles after controlling for historical risk factors. One hundred prison inmates ages 16 to 21 who were juveniles at the time of their adjudication completed personality measures assessing overcontrolled hostility and psychopathic traits, and they reported on the number and types of past violence and the situational correlates (e.g., location of violent episodes, victim characteristics, and precipitating events) to their violent behavior. The measure of overcontrolled hostility and the historical risk assessment indices were not significantly associated with the frequency or variety of past violent behavior nor were they significantly associated with the situational correlates to violence. In contrast, a measure of psychopathic traits demonstrated significant incremental validity after controlling for historical data in its association with the frequency, variety, and situational patterns of violent behavior.

Effects of Climate Change on Freshwater Ecosystems of the South-Eastern United States and the Gulf Coast of Mexico

Abstract: The south-eastern United States and Gulf Coast of Mexico is physiographically diverse, although dominated by a broad coastal plain. Much of the region has a humid, warm temperate climate with little seasonality in precipitation but strong seasonality in runoff owing to high rates of summer evapotranspiration. The climate of southern Florida and eastern Mexico is subtropical with a distinct summer wet season and winter dry season. Regional climate models suggest that climate change resulting from a doubling of the pre-industrial levels of atmospheric CO 2 may increase annual air temperatures by 3-4°C. Changes in precipitation are highly uncertain, but the most probable scenario shows higher levels over all but the northern, interior portions of the region, with increases primarily occurring in summer and occurring as more intense or clustered storms. Despite the increases in precipitation, runoff is likely to decline over much of the region owing to increases in evapotranspiration exceeding increases in precipitation. Only in Florida and the Gulf Coast areas of the US and Mexico are precipitation increases likely to exceed evapotranspiration increases, producing an increase in runoff (...)