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Institution

University of Alabama

EducationTuscaloosa, Alabama, United States
About: University of Alabama is a education organization based out in Tuscaloosa, Alabama, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 27323 authors who have published 48609 publications receiving 1565337 citations. The organization is also known as: Alabama & Bama.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors investigated the complex interrelationships between satisfaction with the retailer, hedonic and utilitarian shopping value, and important retail outcomes, and found that both hedonics and utilitarian values are found to influence key retail outcomes.

857 citations

Journal ArticleDOI
TL;DR: This paper found that the pacific benefits of trade, both total and dyadic, have not been sufficiently appreciated and that democracies are relatively unlikely to become involved in militarized disputes with other democracies, while autocracies and democracies are prone to conflict with each other.
Abstract: The liberals believed that economic interdependence, as well as democracy, would reduce the incidence of interstate conflict. In this article, we test both their economic and their political prescriptions for peace, using pooled-regression analyses of politically relevant dyads for the Cold War era. We find that the pacific benefits of trade, both total and dyadic, have not been sufficiently appreciated. We also offer clear evidence that democracies are relatively unlikely to become involved in militarized disputes with other democracies, while autocracies and democracies are prone to conflict with each other. Since democratic dyads are more peaceful than autocratic dyads, it follows that democracies are more peaceful than autocratic states generally, ceteris paribus. Previous research at the national level of analysis, which led most to conclude that democracies have been no more peaceful than other states, did not consider that the incidence of conflict depends importantly upon the number of contiguous states, the character of their political regimes, and other factors. In addition, we find no evidence that states that have recently undergone regime changes, whether in the democratic or autocratic direction, are particularly conflict prone. Our results suggest the basis for a broader formulation of expected–utility theories of interstate conflict.

851 citations

Journal ArticleDOI
TL;DR: It is shown that CHIP functions with Hsc70 to sense the folded state of CFTR and targets aberrant forms for proteasomal degradation by promoting their ubiquitination.
Abstract: The folding of both wild-type and mutant forms of the cystic-fibrosis transmembrane-conductance regulator (CFTR), a plasma-membrane chloride-ion channel, is inefficient. Most nascent CFTR is retained in the endoplasmic reticulum and degraded by the ubiquitin proteasome pathway. Aberrant folding and defective trafficking of CFTRDeltaF508 is the principal cause of cystic fibrosis, but how the endoplasmic-reticulum quality-control system targets CFTR for degradation remains unknown. CHIP is a cytosolic U-box protein that interacts with Hsc70 through a set of tetratricorepeat motifs. The U-box represents a modified form of the ring-finger motif that is found in ubiquitin ligases and that defines the E4 family of polyubiquitination factors. Here we show that CHIP functions with Hsc70 to sense the folded state of CFTR and targets aberrant forms for proteasomal degradation by promoting their ubiquitination. The U-box appeared essential for this process because overexpresion of CHIPDeltaU-box inhibited the action of endogenous CHIP and blocked CFTR ubiquitination and degradation. CHIP is a co-chaperone that converts Hsc70 from a protein-folding machine into a degradation factor that functions in endoplasmic-reticulum quality control.

850 citations

Journal ArticleDOI
TL;DR: This Review discusses the relative merits of batch and micro flow reactors for performing synthetic chemistry in the laboratory.
Abstract: The fine chemicals and pharmaceutical industries are transforming how their products are manufactured, where economically favorable, from traditional batchwise processes to continuous flow. This evolution is impacting synthetic chemistry on all scales-from the laboratory to full production. This Review discusses the relative merits of batch and micro flow reactors for performing synthetic chemistry in the laboratory.

849 citations

Journal ArticleDOI
TL;DR: In this paper, the task-specific functionality of metal ligating groups, such as those commonly used in preparing ion liquids (ILs), are derived from impidazolium cations.

845 citations


Authors

Showing all 27508 results

NameH-indexPapersCitations
Jasvinder A. Singh1762382223370
Hongfang Liu1662356156290
Ian J. Deary1661795114161
Yongsun Kim1562588145619
Dong-Chul Son138137098686
Simon C. Watkins13595068358
Kenichi Hatakeyama1341731102438
Conor Henderson133138788725
Peter R Hobson133159094257
Tulika Bose132128588895
Helen F Heath132118589466
James Rohlf131121589436
Panos A Razis130128790704
David B. Allison12983669697
Eduardo Marbán12957949586
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202372
2022357
20212,703
20202,759
20192,602
20182,411