Institution
University of Alabama
Education•Tuscaloosa, Alabama, United States•
About: University of Alabama is a education organization based out in Tuscaloosa, Alabama, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 27323 authors who have published 48609 publications receiving 1565337 citations. The organization is also known as: Alabama & Bama.
Topics: Population, Poison control, Large Hadron Collider, Galaxy, Health care
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The Strategy Inventory for Language Learning (SILL) as discussed by the authors is one of the most widely used scales for language learning assessment and has been widely used in many cultures, including the Middle East and Africa.
713 citations
••
TL;DR: Burnout was associated with self-reported unprofessional conduct and less altruistic professional values among medical students at 7 US schools.
Abstract: Context The relationship between professionalism and distress among medical students is unknown. Objective To determine the relationship between measures of professionalism and burnout among US medical students. Design, Setting, and Participants Cross-sectional survey of all medical students attending 7 US medical schools (overall response rate, 2682/4400 [61%]) in the spring of 2009. The survey included the Maslach Burnout Inventory (MBI), the PRIME–MD depression screening instrument, and the SF-8 quality of life (QOL) assessment tool, as well as items exploring students' personal engagement in unprofessional conduct, understanding of appropriate relationships with industry, and attitudes regarding physicians' responsibility to society. Main Outcome Measures Frequency of self-reported cheating/dishonest behaviors, understanding of appropriate relationships with industry as defined by American Medical Association policy, attitudes about physicians' responsibility to society, and the relationship of these dimensions of professionalism to burnout, symptoms of depression, and QOL. Results Of the students who responded to all the MBI items, 1354 of 2566 (52.8%) had burnout. Cheating/dishonest academic behaviors were rare (endorsed by Conclusion Burnout was associated with self-reported unprofessional conduct and less altruistic professional values among medical students at 7 US schools.
712 citations
••
TL;DR: The model of cecal ligation and puncture in rodents has been used extensively to investigate the clinical settings of sepsis and septic shock and is highly versatile in adapting to a range of severity and testing objectives.
Abstract: The model of cecal ligation and puncture (CLP) in rodents has been used extensively to investigate the clinical settings of sepsis and septic shock. This model produces a hyperdynamic, hypermetabolic state that can lead to a hypodynamic, hypometabolic stage, and eventual death. Blood cultures are positive for enteric organisms very early after CLP. The model has been widely used over the past 26 years and is highly versatile in adapting to a range of severity and testing objectives. It is inexpensive to prepare and technically straightforward. Aspects of sepsis research investigated using CLP include energetics, metabolism, resuscitation, antibiotic therapy, microbial factors, cardiovascular responses, immune function, mediator release, and cytokine expression patterns. The challenge of the small circulating blood volume in rodents can be overcome by using micromethods that enable analysis of small volumes, or alternatively, by using a large number of animals to obtain serial samples.
710 citations
••
New England Biolabs1, New York State Department of Health2, Columbia University3, Wayne State University4, University of Basel5, University of Toledo6, University of Edinburgh7, University of Alabama8, University of Portsmouth9, Moscow State University10, University of Illinois at Chicago11, University of Bristol12, University of Rochester13, Duke University14, University of Sheffield15, Vilnius University16, University of Giessen17, University of Copenhagen18, Hungarian Academy of Sciences19, North Carolina State University20, University of Tokyo21, Humboldt University of Berlin22, Brookhaven National Laboratory23, University of Massachusetts Medical School24, National Institutes of Health25, Indian Institute of Science26, University of Warsaw27, University of California, Santa Barbara28, State Research Center of Virology and Biotechnology VECTOR29, University of Oregon30, The Chinese University of Hong Kong31, University of Maryland, College Park32, Fred Hutchinson Cancer Research Center33, University of Wisconsin-Madison34, University of Nebraska–Lincoln35, University of Lisbon36
TL;DR: In this article, a nomenclature for restriction endonucleases, DNA methyltransferases, homing endon nucleases and related genes and gene products is described.
Abstract: A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many different Type II enzymes now identified and provides a system for naming the putative genes found by sequence analysis of microbial genomes.
710 citations
••
TL;DR: Use of carvedilol in the presence of RAS blockade did not affect glycemic control and improved some components of the metabolic syndrome relative to metoprolol in participants with DM and hypertension.
Abstract: Contextβ-Blockers have been shown to decrease cardiovascular risk in patients
with hypertension and type 2 diabetes mellitus (DM); however, some components
of the metabolic syndrome are worsened by some β-blockers.ObjectiveTo compare the effects of β-blockers with different pharmacological
profiles on glycemic and metabolic control in participants with DM and hypertension
receiving renin-angiotensin system (RAS) blockade, in the context of cardiovascular
risk factors.Design, Setting, and ParticipantsA randomized, double-blind, parallel-group trial (The Glycemic Effects
in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives [GEMINI])
conducted between June 1, 2001, and April 6, 2004, at 205 US sites that compared
the effects of carvedilol and metoprolol tartrate on glycemic control. The
1235 participants were aged 36 to 85 years with hypertension (>130/80 mm Hg)
and type 2 DM (glycosylated hemoglobin [HbA1c], 6.5%-8.5%) and
were receiving RAS blockers. Participants were followed up for 35 weeks.InterventionsParticipants were randomized to receive a 6.25- to 25-mg dose of carvedilol
(n = 498) or 50- to 200-mg dose of metoprolol tartrate (n = 737),
each twice daily. Open-label hydrochlorothiazide and a dihydropyridine calcium
antagonist were added, if needed, to achieve blood pressure target.Main Outcome MeasuresDifference between groups in mean change from baseline HbA1c following
5 months of maintenance therapy. Additional prespecified comparisons included
change from baseline HbA1c in individual treatment groups, treatment
effect on insulin sensitivity, and microalbuminuria.ResultsThe 2 groups differed in mean change in HbA1c from baseline
(0.13%; 95% confidence interval [CI], –0.22% to –0.04%; P = .004; modified intention-to-treat analysis).
The mean (SD) HbA1c increased with metoprolol (0.15% [0.04%]; P<.001) but not carvedilol (0.02% [0.04%]; P = .65). Insulin sensitivity improved with carvedilol
(–9.1%; P = .004) but not metoprolol
(–2.0%; P = .48); the between-group
difference was –7.2% (95% CI, –13.8% to –0.2%; P = .004). Blood pressure was similar between groups. Progression
to microalbuminuria was less frequent with carvedilol than with metoprolol
(6.4% vs 10.3%; odds ratio, 0.60; 95% CI, 0.36-0.97; P = .04).ConclusionsBoth β-blockers were well tolerated; use of carvedilol in the presence
of RAS blockade did not affect glycemic control and improved some components
of the metabolic syndrome relative to metoprolol in participants with DM and
hypertension. The effects of the 2 β-blockers on clinical outcomes need
to be compared in long-term clinical trials.
708 citations
Authors
Showing all 27508 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jasvinder A. Singh | 176 | 2382 | 223370 |
Hongfang Liu | 166 | 2356 | 156290 |
Ian J. Deary | 166 | 1795 | 114161 |
Yongsun Kim | 156 | 2588 | 145619 |
Dong-Chul Son | 138 | 1370 | 98686 |
Simon C. Watkins | 135 | 950 | 68358 |
Kenichi Hatakeyama | 134 | 1731 | 102438 |
Conor Henderson | 133 | 1387 | 88725 |
Peter R Hobson | 133 | 1590 | 94257 |
Tulika Bose | 132 | 1285 | 88895 |
Helen F Heath | 132 | 1185 | 89466 |
James Rohlf | 131 | 1215 | 89436 |
Panos A Razis | 130 | 1287 | 90704 |
David B. Allison | 129 | 836 | 69697 |
Eduardo Marbán | 129 | 579 | 49586 |