Institution
University of Alberta
Education•Edmonton, Alberta, Canada•
About: University of Alberta is a education organization based out in Edmonton, Alberta, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 65403 authors who have published 154847 publications receiving 5358338 citations. The organization is also known as: Ualberta & UAlberta.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors link the domains of corporate governance, investment policies, competitive asymmetries, and sustainable capabilities, and propose a framework to link these domains to the domain of sustainable capabilities.
Abstract: This article seeks to link the domains of corporate governance, investment policies, competitive asymmetries, and sustainable capabilities. Conditions such as concentrated ownership, lengthy tenure...
705 citations
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23 Jul 2002TL;DR: A clustering algorithm called CBC (Clustering By Committee) that automatically discovers word senses from text that initially discovers a set of tight clusters called committees that are well scattered in the similarity space.
Abstract: Inventories of manually compiled dictionaries usually serve as a source for word senses. However, they often include many rare senses while missing corpus/domain-specific senses. We present a clustering algorithm called CBC (Clustering By Committee) that automatically discovers word senses from text. It initially discovers a set of tight clusters called committees that are well scattered in the similarity space. The centroid of the members of a committee is used as the feature vector of the cluster. We proceed by assigning words to their most similar clusters. After assigning an element to a cluster, we remove their overlapping features from the element. This allows CBC to discover the less frequent senses of a word and to avoid discovering duplicate senses. Each cluster that a word belongs to represents one of its senses. We also present an evaluation methodology for automatically measuring the precision and recall of discovered senses.
705 citations
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TL;DR: The Late Wisconsinan advance of the Laurentide Ice Sheet started from a Middle Wisconsinan interstadial minimum 27−30 14 C ka BP when the ice margin approximately followed the boundary of the Canadian Shield.
704 citations
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TL;DR: In this article, a standard but flexible methodology is proposed to analyze stratal stacking patterns in a sequence stratigraphic unit, from sequence to systems tract and parasequence.
Abstract: The recurrence of the same types of sequence stratigraphic surface through geologic time defines cycles of change in accommodation or sediment supply, which correspond to sequences in the rock record. These cycles may be symmetrical or asymmetrical, and may or may not include all types of systems tracts that may be expected within a fully developed sequence. Depending on the scale of observation, sequences and their bounding surfaces may be ascribed to different hierarchical orders. Stratal stacking patterns combine to define trends in geometric character that include upstepping, forestepping, backstepping and downstepping, expressing three types of shoreline shift: forced regression (forestepping and downstepping at the shoreline), normal regression (forestepping and upstepping at the shoreline) and transgression (backstepping at the shoreline). Stacking patterns that are independent of shoreline trajectories may also be defined on the basis of changes in depositional style that can be correlated regionally. All stratal stacking patterns reflect the interplay of the same two fundamental variables, namely accommodation (the space available for potential sediment accumulation) and sediment supply. Deposits defined by specific stratal stacking patterns form the basic constituents of any sequence stratigraphic unit, from sequence to systems tract and parasequence. Changes in stratal stacking patterns define the position and timing of key sequence stratigraphic surfaces. Precisely which surfaces are selected as sequence boundaries varies as a function of which surfaces are best expressed within the context of the depositional setting and the preservation of facies relationships and stratal stacking patterns in that succession. The high degree of variability in the expression of sequence stratigraphic units and bounding surfaces in the rock record means ideally that the methodology used to analyze their depositional setting should be flexible from one sequence stratigraphic approach to another. Construction of this framework ensures the success of the method in terms of its objectives to provide a process-based understanding of the stratigraphic architecture. The purpose of this paper is to emphasize a standard but flexible methodology that remains objective.
704 citations
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Max Delbrück Center for Molecular Medicine1, Wellcome Trust Sanger Institute2, European Bioinformatics Institute3, Harvard University4, University of Hamburg5, Sapporo Medical University6, Technische Universität München7, National Institutes of Health8, Howard Hughes Medical Institute9, Brigham and Women's Hospital10, University of Cambridge11, Sun Yat-sen University12, University of Alberta13, British Heart Foundation14
TL;DR: The state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease and provides a valuable reference for future studies.
Abstract: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.
703 citations
Authors
Showing all 66027 results
Name | H-index | Papers | Citations |
---|---|---|---|
Salim Yusuf | 231 | 1439 | 252912 |
Yi Chen | 217 | 4342 | 293080 |
Robert M. Califf | 196 | 1561 | 167961 |
Douglas R. Green | 182 | 661 | 145944 |
Russel J. Reiter | 169 | 1646 | 121010 |
Jiawei Han | 168 | 1233 | 143427 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Tobin J. Marks | 159 | 1621 | 111604 |
Josef M. Penninger | 154 | 700 | 107295 |
Subir Sarkar | 149 | 1542 | 144614 |
Gerald M. Edelman | 147 | 545 | 69091 |
Rinaldo Bellomo | 147 | 1714 | 120052 |
P. Sinervo | 138 | 1516 | 99215 |
David A. Jackson | 136 | 1095 | 68352 |
Andreas Warburton | 135 | 1578 | 97496 |