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Institution

University of Alberta

EducationEdmonton, Alberta, Canada
About: University of Alberta is a education organization based out in Edmonton, Alberta, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 65403 authors who have published 154847 publications receiving 5358338 citations. The organization is also known as: Ualberta & UAlberta.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors extend the Chavas-Cox approach to non-parametric analysis by incorporating undesirable outputs to provide a more complete representation of the production technology, and construct inner and outer nonparametric technology bounds.
Abstract: This article extends the Chavas-Cox approach to non-parametric analysis by incorporating undesirable outputs to provide a more complete representation of the production technology. Inner and outer non-parametric technology bounds are constructed. The methods are illustrated with application to time series data for the Canadian pulp and paper industry. Conventional measures that ignore changes in pollutant outputs underestimate true productivity growth. Further, there is a large gap between estimates generated with reference to inner and outer bounds to the technology, suggesting that researchers need to be aware of the limitations of results derived from analyses relying only on DEA methods. Copyright 2001, Oxford University Press.

588 citations

Journal ArticleDOI
TL;DR: In this paper, a new imaginary refractive index spectrum of water has been determined between 4000 and 700 cm-1 as the average of spectra calculated from ATR spectra recorded by four workers in their laboratory over the past seven years.
Abstract: The previously reported nonreproducibility of the intensity of the OH stretching band of liquid water has been explored. It was found that it can be eliminated in measurements with the Circle® multiple ATR cell by ensuring that the ATR rod is coaxial with the glass liquid holder. It was also found that normal laboratory temperature variations of a few degrees change the intensity by ≤~1% of the peak height. A new imaginary refractive index spectrum of water has been determined between 4000 and 700 cm-1 as the average of spectra calculated from ATR spectra recorded by four workers in our laboratory over the past seven years. It was obtained under experimental and computational conditions superior to those used previously, but is only marginally different from the spectra reported in 1989. In particular, the integrated intensities of the fundamentals are not changed significantly from those reported in 1989. The available imaginary refractive index, k, values between 15,000 and 1 cm-1 have been compared. The values that are judged to be the most reliable have been combined into a recommended k spectrum of H2O(l) at 25°C between 15,000 and 1 cm-1, from which the real refractive index spectrum has been calculated by Kramers-Kronig transformation. The recommended values of the real and imaginary refractive indices and molar absorption coefficients of liquid water at 25 ± 1 °C are presented in graphs and tables. The real and imaginary dielectric constants and the real and imaginary molar polarizabilities in this wavenumber range can be calculated from the tables. Conservatively estimated probable errors of the recommended k values are given. The precision with which the values can be measured in one laboratory and the relative errors between regions are, of course, far smaller than these probable errors. The recommended k values should be of considerable value as interim standard intensities of liquid water, which will facilitate the transfer of intensities between laboratories.

588 citations

Journal ArticleDOI
Lauren A. Weiss1, Lauren A. Weiss2, Dan E. Arking3, Mark J. Daly1  +211 moreInstitutions (54)
08 Oct 2009-Nature
TL;DR: A linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms in a common set of 1,031 multiplex autism families, implicating SEMA5A as an autism susceptibility gene.
Abstract: Although autism is a highly heritable neurodevelopmental disorder, attempts to identify specific susceptibility genes have thus far met with limited success. Genome-wide association studies using half a million or more markers, particularly those with very large sample sizes achieved through meta-analysis, have shown great success in mapping genes for other complex genetic traits. Consequently, we initiated a linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms (SNPs) in a common set of 1,031 multiplex autism families (1,553 affected offspring). We identified regions of suggestive and significant linkage on chromosomes 6q27 and 20p13, respectively. Initial analysis did not yield genome-wide significant associations; however, genotyping of top hits in additional families revealed an SNP on chromosome 5p15 (between SEMA5A and TAS2R1) that was significantly associated with autism (P = 2 x 10(-7)). We also demonstrated that expression of SEMA5A is reduced in brains from autistic patients, further implicating SEMA5A as an autism susceptibility gene. The linkage regions reported here provide targets for rare variation screening whereas the discovery of a single novel association demonstrates the action of common variants.

587 citations

Journal ArticleDOI
TL;DR: This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS, and summarizes the components of the intestinal barrier including the tight junction complex within the epithelium.
Abstract: Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI) tract. There is growing evidence that increases in intestinal permeability plays a pathogenic role in diseases, such as inflammatory bowel disease (IBD) and celiac disease, and functional bowel disorders, such as irritable bowel syndrome (IBS). This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS. The review summarizes the components of the intestinal barrier including the tight junction complex within the epithelium, and the methods used to assess gut permeability both in vitro and in vivo. Throughout the review, the authors have attempted to critically review the latest research from both experimental animal models and human studies to appraise whether intestinal barrier dysfunction is a primary cause of functional GI disorders, such as IBS.…

587 citations

Journal ArticleDOI
TL;DR: Response and remission rates for natalizumab were superior to those for placebo at Weeks 4, 8, and 12, demonstrating the early and sustained efficacy of natalIZumab as induction therapy in patients with elevated C-reactive protein and active Crohn's disease.

587 citations


Authors

Showing all 66027 results

NameH-indexPapersCitations
Salim Yusuf2311439252912
Yi Chen2174342293080
Robert M. Califf1961561167961
Douglas R. Green182661145944
Russel J. Reiter1691646121010
Jiawei Han1681233143427
Jaakko Kaprio1631532126320
Tobin J. Marks1591621111604
Josef M. Penninger154700107295
Subir Sarkar1491542144614
Gerald M. Edelman14754569091
Rinaldo Bellomo1471714120052
P. Sinervo138151699215
David A. Jackson136109568352
Andreas Warburton135157897496
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023234
20221,084
20219,315
20208,831
20198,177