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Institution

University of Alberta

EducationEdmonton, Alberta, Canada
About: University of Alberta is a education organization based out in Edmonton, Alberta, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 65403 authors who have published 154847 publications receiving 5358338 citations. The organization is also known as: Ualberta & UAlberta.


Papers
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Journal ArticleDOI
TL;DR: In this article, the mass and radius of the isolated 205.53 Hz millisecond pulsar PSR J0030+0451 were estimated using a Bayesian inference approach to analyze its energy-dependent thermal X-ray waveform.
Abstract: Neutron stars are not only of astrophysical interest, but are also of great interest to nuclear physicists, because their attributes can be used to determine the properties of the dense matter in their cores. One of the most informative approaches for determining the equation of state of this dense matter is to measure both a star's equatorial circumferential radius $R_e$ and its gravitational mass $M$. Here we report estimates of the mass and radius of the isolated 205.53 Hz millisecond pulsar PSR J0030+0451 obtained using a Bayesian inference approach to analyze its energy-dependent thermal X-ray waveform, which was observed using the Neutron Star Interior Composition Explorer (NICER). This approach is thought to be less subject to systematic errors than other approaches for estimating neutron star radii. We explored a variety of emission patterns on the stellar surface. Our best-fit model has three oval, uniform-temperature emitting spots and provides an excellent description of the pulse waveform observed using NICER. The radius and mass estimates given by this model are $R_e = 13.02^{+1.24}_{-1.06}$ km and $M = 1.44^{+0.15}_{-0.14}\ M_\odot$ (68%). The independent analysis reported in the companion paper by Riley et al. (2019) explores different emitting spot models, but finds spot shapes and locations and estimates of $R_e$ and $M$ that are consistent with those found in this work. We show that our measurements of $R_e$ and $M$ for PSR J0030$+$0451 improve the astrophysical constraints on the equation of state of cold, catalyzed matter above nuclear saturation density.

586 citations

Journal ArticleDOI
12 Jan 2001-Cell
TL;DR: It is reported that XRCC1 interacts with human polynucleotide kinase in addition to its established interactions with DNA polymerase-beta and DNA ligase III, which identifies a novel pathway for mammalian single-strand break repair and demonstrates a concerted role for XR CCP and PNK in the initial step of processing damaged DNA ends.

586 citations

Journal ArticleDOI
TL;DR: What is known about the mechanisms of cholesterol uptake, esterification and release in macrophages is described to help develop novel therapeutic interventions for atherosclerosis.

586 citations

Journal ArticleDOI
TL;DR: A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology of PrCa1.
Abstract: Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10−9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55–2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04–6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa1. A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology.

585 citations

Journal ArticleDOI
TL;DR: The clinical and genetic knowledge for each cardiomyopathy varies, as did the recommendations and strength of evidence, whereas ARVD/C and LVNC are relative newcomers to the field.

585 citations


Authors

Showing all 66027 results

NameH-indexPapersCitations
Salim Yusuf2311439252912
Yi Chen2174342293080
Robert M. Califf1961561167961
Douglas R. Green182661145944
Russel J. Reiter1691646121010
Jiawei Han1681233143427
Jaakko Kaprio1631532126320
Tobin J. Marks1591621111604
Josef M. Penninger154700107295
Subir Sarkar1491542144614
Gerald M. Edelman14754569091
Rinaldo Bellomo1471714120052
P. Sinervo138151699215
David A. Jackson136109568352
Andreas Warburton135157897496
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023234
20221,084
20219,315
20208,831
20198,177