Institution
University of Alberta
Education•Edmonton, Alberta, Canada•
About: University of Alberta is a education organization based out in Edmonton, Alberta, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 65403 authors who have published 154847 publications receiving 5358338 citations. The organization is also known as: Ualberta & UAlberta.
Papers published on a yearly basis
Papers
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University of Maryland, College Park1, University of Illinois at Urbana–Champaign2, Columbia University3, Goddard Space Flight Center4, Centre National D'Etudes Spatiales5, University of Southampton6, Haverford College7, Stony Brook University8, California Institute of Technology9, University of Alberta10, United States Naval Research Laboratory11, Kyoto University12, Massachusetts Institute of Technology13
TL;DR: In this article, the mass and radius of the isolated 205.53 Hz millisecond pulsar PSR J0030+0451 were estimated using a Bayesian inference approach to analyze its energy-dependent thermal X-ray waveform.
Abstract: Neutron stars are not only of astrophysical interest, but are also of great interest to nuclear physicists, because their attributes can be used to determine the properties of the dense matter in their cores. One of the most informative approaches for determining the equation of state of this dense matter is to measure both a star's equatorial circumferential radius $R_e$ and its gravitational mass $M$. Here we report estimates of the mass and radius of the isolated 205.53 Hz millisecond pulsar PSR J0030+0451 obtained using a Bayesian inference approach to analyze its energy-dependent thermal X-ray waveform, which was observed using the Neutron Star Interior Composition Explorer (NICER). This approach is thought to be less subject to systematic errors than other approaches for estimating neutron star radii. We explored a variety of emission patterns on the stellar surface. Our best-fit model has three oval, uniform-temperature emitting spots and provides an excellent description of the pulse waveform observed using NICER. The radius and mass estimates given by this model are $R_e = 13.02^{+1.24}_{-1.06}$ km and $M = 1.44^{+0.15}_{-0.14}\ M_\odot$ (68%). The independent analysis reported in the companion paper by Riley et al. (2019) explores different emitting spot models, but finds spot shapes and locations and estimates of $R_e$ and $M$ that are consistent with those found in this work. We show that our measurements of $R_e$ and $M$ for PSR J0030$+$0451 improve the astrophysical constraints on the equation of state of cold, catalyzed matter above nuclear saturation density.
586 citations
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TL;DR: It is reported that XRCC1 interacts with human polynucleotide kinase in addition to its established interactions with DNA polymerase-beta and DNA ligase III, which identifies a novel pathway for mammalian single-strand break repair and demonstrates a concerted role for XR CCP and PNK in the initial step of processing damaged DNA ends.
586 citations
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TL;DR: What is known about the mechanisms of cholesterol uptake, esterification and release in macrophages is described to help develop novel therapeutic interventions for atherosclerosis.
586 citations
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Fredrick R. Schumacher1, Ali Amin Al Olama2, Sonja I. Berndt3, Sara Benlloch2 +204 more•Institutions (79)
TL;DR: A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology of PrCa1.
Abstract: Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10−9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55–2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04–6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa1. A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology.
585 citations
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TL;DR: The clinical and genetic knowledge for each cardiomyopathy varies, as did the recommendations and strength of evidence, whereas ARVD/C and LVNC are relative newcomers to the field.
585 citations
Authors
Showing all 66027 results
Name | H-index | Papers | Citations |
---|---|---|---|
Salim Yusuf | 231 | 1439 | 252912 |
Yi Chen | 217 | 4342 | 293080 |
Robert M. Califf | 196 | 1561 | 167961 |
Douglas R. Green | 182 | 661 | 145944 |
Russel J. Reiter | 169 | 1646 | 121010 |
Jiawei Han | 168 | 1233 | 143427 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Tobin J. Marks | 159 | 1621 | 111604 |
Josef M. Penninger | 154 | 700 | 107295 |
Subir Sarkar | 149 | 1542 | 144614 |
Gerald M. Edelman | 147 | 545 | 69091 |
Rinaldo Bellomo | 147 | 1714 | 120052 |
P. Sinervo | 138 | 1516 | 99215 |
David A. Jackson | 136 | 1095 | 68352 |
Andreas Warburton | 135 | 1578 | 97496 |