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Showing papers by "University of Alcalá published in 2014"


Journal ArticleDOI
TL;DR: In this paper, the authors studied the properties of massive, galactic-scale outflows of molecular gas and investigated their impact on galaxy evolution, finding that the presence of an active galactic nucleus (AGN) can boost the outflow rate by a large factor, which is found to increase with the L-AGN/L-bol ratio.
Abstract: We study the properties of massive, galactic-scale outflows of molecular gas and investigate their impact on galaxy evolution. We present new IRAMPdBI CO(1-0) observations of local ultra-luminous infrared galaxies (ULIRGs) and quasar-hosts: a clear signature of massive and energetic molecular outflows, extending on kpc scales, is found in the CO(1-0) kinematics of four out of seven sources, with measured outflow rates of several 100M(circle dot)yr(-1). We combine these new observations with data from the literature, and explore the nature and origin of massive molecular outflows within an extended sample of 19 local galaxies. We find that starburst-dominated galaxies have an outflow rate comparable to their star formation rate (SFR), or even higher by a factor of similar to 2-4, implying that starbursts can indeed be effective in removing cold gas from galaxies. Nevertheless, our results suggest that the presence of an active galactic nucleus (AGN) can boost the outflow rate by a large factor, which is found to increase with the L-AGN/L-bol ratio. The gas depletion time scales due to molecular outflows are anti-correlated with the presence and luminosity of an AGN in these galaxies, and range from a few hundred million years in starburst galaxies down to just a few million years in galaxies hosting powerful AGNs. In quasar hosts, the depletion time scales due to the outflow are much shorter than the depletion time scales due to star formation. We estimate the outflow kinetic power and find that, for galaxies hosting powerful AGNs, it corresponds to about 5% of the AGN luminosity, as expected by models of AGN feedback. Moreover, we find that momentum rates of about 20 L-AGN/c are common among the AGN-dominated sources in our sample. For "pure" starburst galaxies, our data tentatively support models in which outflows are mostly momentum-driven by the radiation pressure from young stars onto dusty clouds. Overall, our results indicate that, although starbursts are effective in powering massive molecular outflows, the presence of an AGN may strongly enhance such outflows, and therefore have a profound feedback effect on the evolution of galaxies by efficiently removing fuel for star formation, hence quenching star formation.

898 citations


Journal ArticleDOI
TL;DR: Cirrhosis-associated immune dysfunction phenotypes switch from predominantly "pro-inflammatory" to predominantly "immunodeficient" in patients with stable ascitic cirrhosis and in Patients with severely decompensated cirrhoses and extra-hepatic organ failure (e.g. acute-on-chronic liver failure), respectively.

795 citations


Journal ArticleDOI
TL;DR: It is shown that when population differentiation is accounted for and dispersal is restricted, forecasts of species range shifts under climate change are even more pessimistic than those using the conventional assumption of homogeneously high plasticity across a species' range.
Abstract: Species are the unit of analysis in many global change and conservation biology studies; however, species are not uniform entities but are composed of different, sometimes locally adapted, populations differing in plasticity We examined how intraspecific variation in thermal niches and phenotypic plasticity will affect species distributions in a warming climate We first developed a conceptual model linking plasticity and niche breadth, providing five alternative intraspecific scenarios that are consistent with existing literature Secondly, we used ecological niche-modeling techniques to quantify the impact of each intraspecific scenario on the distribution of a virtual species across a geographically realistic setting Finally, we performed an analogous modeling exercise using real data on the climatic niches of different tree provenances We show that when population differentiation is accounted for and dispersal is restricted, forecasts of species range shifts under climate change are even more pessimistic than those using the conventional assumption of homogeneously high plasticity across a species' range Suitable population-level data are not available for most species so identifying general patterns of population differentiation could fill this gap However, the literature review revealed contrasting patterns among species, urging greater levels of integration among empirical, modeling and theoretical research on intraspecific phenotypic variation

756 citations


Journal ArticleDOI
06 Mar 2014-Nature
TL;DR: A global analysis of 403 tropical and temperate tree species shows that for most species mass growth rate increases continuously with tree size, which means large, old trees do not act simply as senescent carbon reservoirs but actively fix large amounts of carbon compared to smaller trees.
Abstract: Forests are major components of the global carbon cycle, providing substantial feedback to atmospheric greenhouse gas concentrations. Our ability to understand and predict changes in the forest carbon cycle--particularly net primary productivity and carbon storage--increasingly relies on models that represent biological processes across several scales of biological organization, from tree leaves to forest stands. Yet, despite advances in our understanding of productivity at the scales of leaves and stands, no consensus exists about the nature of productivity at the scale of the individual tree, in part because we lack a broad empirical assessment of whether rates of absolute tree mass growth (and thus carbon accumulation) decrease, remain constant, or increase as trees increase in size and age. Here we present a global analysis of 403 tropical and temperate tree species, showing that for most species mass growth rate increases continuously with tree size. Thus, large, old trees do not act simply as senescent carbon reservoirs but actively fix large amounts of carbon compared to smaller trees; at the extreme, a single big tree can add the same amount of carbon to the forest within a year as is contained in an entire mid-sized tree. The apparent paradoxes of individual tree growth increasing with tree size despite declining leaf-level and stand-level productivity can be explained, respectively, by increases in a tree's total leaf area that outpace declines in productivity per unit of leaf area and, among other factors, age-related reductions in population density. Our results resolve conflicting assumptions about the nature of tree growth, inform efforts to undertand and model forest carbon dynamics, and have additional implications for theories of resource allocation and plant senescence.

692 citations


Journal ArticleDOI
TL;DR: Testing both social networking and gamification in an undergraduate course found that both approaches presented better performance than a traditional e-learning approach in terms of academic achievement for practical assignments, but that, when it came to assessing knowledge, theTraditional e- learning approach was better.
Abstract: While social networking has already demonstrated its efficiency in e-learning, gamification, which is the use of game-thinking and playful design in non-game contexts, has only shown its potential as a motivational tool. This paper presents the results of testing both social networking and gamification in an undergraduate course, comparing them in terms their effect on students' academic achievement, participation and attitude. The effects of a gamification plugin deployed in a learning management system were compared to those of a social networking site in the same educational setting. We found that both approaches presented better performance than a traditional e-learning approach in terms of academic achievement for practical assignments, but that, when it came to assessing knowledge, the traditional e-learning approach was better. Also challenging current assumptions, participation rates and scores remained low with the new tools, although students' attitudes were positive.

482 citations



Journal ArticleDOI
16 Jan 2014-Nature
TL;DR: An almost complete mitochondrial genome sequence of a hominin from Sima de los Huesos is determined and it is shown that it is closely related to the lineage leading to mitochondrial genomes of Denisovans, an eastern Eurasian sister group to Neanderthals.
Abstract: Excavations of a complex of caves in the Sierra de Atapuerca in northern Spain have unearthed hominin fossils that range in age from the early Pleistocene to the Holocene1. One of these sites, the ‘Sima de los Huesos’ (‘pit of bones’), has yielded the world’s largest assemblage of Middle Pleistocene hominin fossils2,3, onsisting of at least 28 individuals4 dated to over 300,000 years ago5. The skeletal remains share a number of morphological features with fossils classifieds Homo heidelbergensis and also display distinct neanderthalderived traits6–8. Here we determine an almost complete mitochondrial genome sequence of a hominin from Sima de los Huesos and show that it is closely related to the lineage leading to mitochondrial genomes of enisovans 9,10, an eastern Eurasian sister group to Neanderthals. Our results pave the way for DNA research on hominins from the Middle Pleistocene.

414 citations


Journal ArticleDOI
A. Aab1, P. Abreu2, P. Abreu3, Marco Aglietta4  +511 moreInstitutions (70)
TL;DR: In this article, a study of the distributions of the depth of maximum, X-max, of extensive air-shower profiles with energies above 10(17.8) eV was performed with the fluorescence telescopes of the Pierre Auger Observatory.
Abstract: We report a study of the distributions of the depth of maximum, X-max, of extensive air-shower profiles with energies above 10(17.8) eV as observed with the fluorescence telescopes of the Pierre Auger Observatory. The analysis method for selecting a data sample with minimal sampling bias is described in detail as well as the experimental cross-checks and systematic uncertainties. Furthermore, we discuss the detector acceptance and the resolution of the X-max measurement and provide parametrizations thereof as a function of energy. The energy dependence of the mean and standard deviation of the X-max distributions are compared to air-shower simulations for different nuclear primaries and interpreted in terms of the mean and variance of the logarithmic mass distribution at the top of the atmosphere.

408 citations


Journal ArticleDOI
TL;DR: The Task Force recommends using FNPO rather than FNPO for the definition of PCOM setting the threshold at ≥25, but only when using newer technology that affords maximal resolution of ovarian follicles (i.e. transducer frequency ≥8 MHz).
Abstract: BACKGROUND The diagnosis of polycystic ovary syndrome (PCOS) relies on clinical, biological and morphological criteria. With the advent of ultrasonography, follicle excess has become the main aspect of polycystic ovarian morphology (PCOM). Since 2003, most investigators have used a threshold of 12 follicles (measuring 2-9 mm in diameter) per whole ovary, but that now seems obsolete. An increase in ovarian volume (OV) and/or area may also be considered accurate markers of PCOM, yet their utility compared with follicle excess remains unclear. METHODS Published peer-reviewed medical literature about PCOM was searched using PubMed.gov online facilities and was submitted to critical assessment by a panel of experts. Studies reporting antral follicle counts (AFC) or follicle number per ovary (FNPO) using transvaginal ultrasonography in healthy women of reproductive age were also included. Only studies that reported the mean or median AFC or FNPO of follicles measuring 2-9 mm, 2-10 mm or <10 mm in diameter, or visualized all follicles, were included. RESULTS Studies addressing women recruited from the general population and studies comparing control and PCOS populations with appropriate statistics were convergent towards setting the threshold for increased FNPO at ≥25 follicles, in women aged 18-35 years. These studies suggested maintaining the threshold for increased OV at ≥10 ml. Critical analysis of the literature showed that OV had less diagnostic potential for PCOM compared with FNPO. The review did not identify any additional diagnostic advantage for other ultrasound metrics such as specific measurements of ovarian stroma or blood flow. Even though serum concentrations of anti-Mullerian hormone (AMH) showed a diagnostic performance for PCOM that was equal to or better than that of FNPO in some series, the accuracy and reproducibility issues of currently available AMH assays preclude the establishment of a threshold value for its use as a surrogate marker of PCOM. PCOM does not associate with significant consequences for health in the absence of other symptoms of PCOS but, because of the use of inconsistent definitions of PCOM among studies, this question cannot be answered with absolute certainty. CONCLUSIONS The Task Force recommends using FNPO for the definition of PCOM setting the threshold at ≥25, but only when using newer technology that affords maximal resolution of ovarian follicles (i.e. transducer frequency ≥8 MHz). If such technology is not available, we recommend using OV rather than FNPO for the diagnosis of PCOM for routine daily practice but not for research studies that require the precise full characterization of patients. The Task Force recognizes the still unmet need for standardization of the follicle counting technique and the need for regularly updating the thresholds used to define follicle excess, particularly in diverse populations. Serum AMH concentration generated great expectations as a surrogate marker for the follicle excess of PCOM, but full standardization of AMH assays is needed before they can be routinely used for clinical practice and research. Finally, the finding of PCOM in ovulatory women not showing clinical or biochemical androgen excess may be inconsequential, even though some studies suggest that isolated PCOM may represent the milder end of the PCOS spectrum.

402 citations


Journal ArticleDOI
TL;DR: Eyelash loss, facial papules, and body hair involvement were associated with severe FFA, and antiandrogens were the most useful treatment.
Abstract: Background To our knowledge, there are no large multicenter studies concerning frontal fibrosing alopecia (FFA) that could give clues about its pathogenesis and best treatment. Objective We sought to describe the epidemiology, comorbidities, clinical presentation, diagnostic findings, and therapeutic choices in a large series of patients with FFA. Methods This retrospective multicenter study included patients given the diagnosis of FFA. Clinical severity was classified based on the recession of the frontotemporal hairline. Results In all, 355 patients (343 women [49 premenopausal] and 12 men) with a mean age of 61 years (range 23-86) were included. Early menopause was detected in 49 patients (14%), whereas 46 (13%) had undergone hysterectomy. Severe FFA was observed in 131 patients (37%). Independent factors associated with severe FFA after multivariate analysis were: eyelash loss, facial papules, and body hair involvement. Eyebrow loss as the initial clinical presentation was associated with mild forms. Antiandrogens such as finasteride and dutasteride were used in 111 patients (31%), with improvement in 52 (47%) and stabilization in 59 (53%). Limitations The retrospective design is a limitation. Conclusions Eyelash loss, facial papules, and body hair involvement were associated with severe FFA. Antiandrogens were the most useful treatment.

359 citations


Journal ArticleDOI
20 Jun 2014-Science
TL;DR: The sample shows a consistent morphological pattern with derived Neandertal features present in the face and anterior vault, many of which are related to the masticatory apparatus, pointing to a mosaic pattern of evolution.
Abstract: Seventeen Middle Pleistocene crania from the Sima de los Huesos site (Atapuerca, Spain) are analyzed, including seven new specimens. This sample makes it possible to thoroughly characterize a Middle Pleistocene hominin paleodeme and to address hypotheses about the origin and evolution of the Neandertals. Using a variety of techniques, the hominin-bearing layer could be reassigned to a period around 430,000 years ago. The sample shows a consistent morphological pattern with derived Neandertal features present in the face and anterior vault, many of which are related to the masticatory apparatus. This suggests that facial modification was the first step in the evolution of the Neandertal lineage, pointing to a mosaic pattern of evolution, with different anatomical and functional modules evolving at different rates.

Journal ArticleDOI
TL;DR: The present review reveals the serious contamination status of Italian surface water and groundwater especially by pesticides, industrials and to a lower extent by pharmaceuticals and the necessity to foster the research on EOC occurrence in Italian water resources, in particular in Southern Italy where a limited number of investigations currently exist.

Journal ArticleDOI
TL;DR: An overview of the common and distinctive features of retinal neurodegenerative diseases, including the molecular, anatomical and functional changes caused by the cellular response to damage, are provided in order to establish appropriate treatments for these pathologies.

Journal ArticleDOI
TL;DR: In this article, a number of microfungi were described from South Africa, including Cercosporella dolichandrae from Dolichandra unguiscati, Seiridium podocarpi from Podocarpus latifolius, Pseudocercospora parapseudarthriae from Pseudarthria hookeri, Neodevriesia coryneliae from Corynelia uberata on leaves of Afrocarpus falcatus, Ramichloridium eucleae from Euclea undulata and
Abstract: Novel species of microfungi described in the present study include the following from South Africa: Cercosporella dolichandrae from Dolichandra unguiscati, Seiridium podocarpi from Podocarpus latifolius, Pseudocercospora parapseudarthriae from Pseudarthria hookeri, Neodevriesia coryneliae from Corynelia uberata on leaves of Afrocarpus falcatus, Ramichloridium eucleae from Euclea undulata and Stachybotrys aloeticola from Aloe sp. (South Africa), as novel member of the Stachybotriaceae fam. nov. Several species were also described from Zambia, and these include Chaetomella zambiensis on unknown Fabaceae, Schizoparme pseudogranati from Terminalia stuhlmannii, Diaporthe isoberliniae from Isoberlinia angolensis, Peyronellaea combreti from Combretum mossambiciensis, Zasmidium rothmanniae and Phaeococcomyces rothmanniae from Rothmannia engleriana, Diaporthe vangueriae from Vangueria infausta and Diaporthe parapterocarpi from Pterocarpus brenanii. Novel species from the Netherlands include: Stagonospora trichophoricola, Keissleriella trichophoricola and Dinemasporium trichophoricola from Trichophorum cespitosum, Phaeosphaeria poae, Keissleriella poagena, Phaeosphaeria poagena, Parastagonospora poagena and Pyrenochaetopsis poae from Poa sp., Septoriella oudemansii from Phragmites australis and Dendryphion europaeum from Hedera helix (Germany) and Heracleum sphondylium (the Netherlands). Novel species from Australia include: Anungitea eucalyptorum from Eucalyptus leaf litter, Beltraniopsis neolitseae and Acrodontium neolitseae from Neolitsea australiensis, Beltraniella endiandrae from Endiandra introrsa, Phaeophleospora parsoniae from Parsonia straminea, Penicillifer martinii from Cynodon dactylon, Ochroconis macrozamiae from Macrozamia leaf litter, Triposporium cycadicola, Circinotrichum cycadis, Cladosporium cycadicola and Acrocalymma cycadis from Cycas spp. Furthermore, Vermiculariopsiella dichapetali is described from Dichapetalum rhodesicum (Botswana), Marasmius vladimirii from leaf litter (India), Ophiognomonia acadiensis from Picea rubens (Canada), Setophoma vernoniae from Vernonia polyanthes and Penicillium restingae from soil (Brazil), Pseudolachnella guaviyunis from Myrcianthes pungens (Uruguay) and Pseudocercospora neriicola from Nerium oleander (Italy). Novelties from Spain include: Dendryphiella eucalyptorum from Eucalyptus globulus, Conioscypha minutispora from dead wood, Diplogelasinospora moalensis and Pseudoneurospora canariensis from soil and Inocybe lanatopurpurea from reforested woodland of Pinus spp. Novelties from France include: Kellermania triseptata from Agave angustifolia, Zetiasplozna acaciae from Acacia melanoxylon, Pyrenochaeta pinicola from Pinus sp. and Pseudonectria rusci from Ruscus aculeatus. New species from China include: Dematiocladium celtidicola from Celtis bungeana, Beltrania pseudorhombica, Chaetopsina beijingensis and Toxicocladosporium pini from Pinus spp. and Setophaeosphaeria badalingensis from Hemerocallis fulva. Novel genera of Ascomycetes include Alfaria from Cyperus esculentus (Spain), Rinaldiella from a contaminated human lesion (Georgia), Hyalocladosporiella from Tectona grandis (Brazil), Pseudoacremonium from Saccharum spontaneum and Melnikomyces from leaf litter (Vietnam), Annellosympodiella from Juniperus procera (Ethiopia), Neoceratosperma from Eucalyptus leaves (Thailand), Ramopenidiella from Cycas calcicola (Australia), Cephalotrichiella from air in the Netherlands, Neocamarosporium from Mesembryanthemum sp. and Acervuloseptoria from Ziziphus mucronata (South Africa) and Setophaeosphaeria from Hemerocallis fulva (China). Several novel combinations are also introduced, namely for Phaeosphaeria setosa as Setophaeosphaeria setosa, Phoma heteroderae as Peyronellaea heteroderae and Phyllosticta maydis as Peyronellaea maydis. Morphological and culture characteristics along with ITS DNA barcodes are provided for all taxa.

Journal ArticleDOI
TL;DR: In this paper, the utility of two forms of filtering the calibration data set (geographic and environmental) to reduce the effects of sampling bias is addressed, and a virtual species, projected its niche to the Iberian Peninsula and took samples from its binary geographic distribution using several biases.
Abstract: Ecological niche models represent key tools in biogeography but the effects of biased sampling hinder their use. Here, we address the utility of two forms of filtering the calibration data set (geographic and environmental) to reduce the effects of sampling bias. To do so we created a virtual species, projected its niche to the Iberian Peninsula and took samples from its binary geographic distribution using several biases. We then built models for various sample sizes after applying each of the filtering approaches. While geographic filtering did not improve discriminatory ability (and sometimes worsened it), environmental filtering consistently led to better models. Models made with few but climatically filtered points performed better than those made with many unfiltered (biased) points. Future research should address additional factors such as the complexity of the species’ niche, strength of filtering, and ability to predict suitability (rather than focus purely on discrimination).

Journal ArticleDOI
A. Aab1, P. Abreu2, Marco Aglietta3, E. J. Ahn4  +481 moreInstitutions (53)
TL;DR: In this article, the authors examined the implications of the distributions of the depths of atmospheric shower maximum (X-max) using a hybrid technique, for composition and hadronic interaction models, and found that their data are not well described by a mix of protons and iron nuclei over most of the energy range.
Abstract: Using the data taken at the Pierre Auger Observatory between December 2004 and December 2012, we have examined the implications of the distributions of depths of atmospheric shower maximum (X-max), using a hybrid technique, for composition and hadronic interaction models. We do this by fitting the distributions with predictions from a variety of hadronic interaction models for variations in the composition of the primary cosmic rays and examining the quality of the fit. Regardless of what interaction model is assumed, we find that our data are not well described by a mix of protons and iron nuclei over most of the energy range. Acceptable fits can be obtained when intermediate masses are included, and when this is done consistent results for the proton and iron-nuclei contributions can be found using the available models. We observe a strong energy dependence of the resulting proton fractions, and find no support from any of the models for a significant contribution from iron nuclei. However, we also observe a significant disagreement between the models with respect to the relative contributions of the intermediate components.

Journal ArticleDOI
TL;DR: Kattge et al. as mentioned in this paper used the TRY initiative and database on plant traits to identify plant traits in order to improve plant traits identification and gene expression in the field of biogeochemistry.
Abstract: This research was initially supported by INTERBOS3-CGL2008-04503-C03-03 and SUM2008-00004-C03-01 projects, and by FUNDIV (ENV.2010.2.1.4-1) at a later stage. PRB was supported by a FPU fellowship (AP2008-01325). The study has been supported by the TRY initiative on plant traits (http://www.trydb.org). The TRY initiative and database is hosted, developed and maintained by J. Kattge and G. Bonisch (Max-Planck-Institute for Biogeochemistry, Jena, Germany). TRY is supported by DIVERSITAS, IGBP, the Global Land Project, the UK Natural Environment Research Council (NERC) through its program QUEST (Quantifying and Understanding the Earth System), the French Fondation pour la Recherche sur la Biodiversite (FRB) and GIS "Climat Environnement et Societe" France.

Journal ArticleDOI
TL;DR: This paper focuses on the exploitation of linear-frequency-modulated continuous-wave radars for noncontact range tracking of vital signs, e.g., respiration, and a rigorous mathematical analysis of the operating principle of the LFMCW radar in the context of vital-sign monitoring is detailed.
Abstract: This paper focuses on the exploitation of linear-frequency-modulated continuous-wave (LFMCW) radars for noncontact range tracking of vital signs, e.g., respiration. Such short-range system combines hardware simplicity and tracking precision, thus outperforming other remote-sensing approaches in the addressed biomedical scenario. A rigorous mathematical analysis of the operating principle of the LFMCW radar in the context of vital-sign monitoring, which includes the explanation of key aspects for the maintenance of coherence, is detailed. A precise phase-based range-tracking algorithm is also presented. Exhaustive simulations are carried out to confirm the suitability and robustness against clutter, noise, and multiple scatterers of the proposed radar architecture, which is subsequently implemented at the prototype level. Moreover, live data from real experiments associated to a metal plate and breathing subjects are obtained and studied.

Journal ArticleDOI
TL;DR: Ghrelin is a peptide secreted from the stomach and, in contrast to other gut hormones, plasma levels decrease after a meal and potently stimulate food intake, whereas other circulating factors such as insulin and leptin relay information regarding long-term energy stores.
Abstract: The mechanisms for controlling food intake involve mainly an interplay between gut, brain, and adipose tissue (AT), among the major organs. Parasympathetic, sympathetic, and other systems are required for communication between the brain satiety center, gut, and AT. These neuronal circuits include a variety of peptides and hormones, being ghrelin the only orexigenic molecule known, whereas the plethora of other factors are inhibitors of appetite, suggesting its physiological relevance in the regulation of food intake and energy homeostasis. Nutrients generated by food digestion have been proposed to activate G-protein-coupled receptors on the luminal side of enteroendocrine cells, e.g., the L-cells. This stimulates the release of gut hormones into the circulation such as glucagon-like peptide-1 (GLP-1), oxyntomodulin, pancreatic polypeptides, peptide tyrosine tyrosine, and cholecystokinin, which inhibit appetite. Ghrelin is a peptide secreted from the stomach and, in contrast to other gut hormones, plasma levels decrease after a meal and potently stimulate food intake. Other circulating factors such as insulin and leptin relay information regarding long-term energy stores. Both hormones circulate at proportional levels to body fat content, enter the CNS proportionally to their plasma levels, and reduce food intake. Circulating hormones can influence the activity of the arcuate nucleus (ARC) neurons of the hypothalamus, after passing across the median eminence. Circulating factors such as gut hormones may also influence the nucleus of the tractus solitarius (NTS) through the adjacent circumventricular organ. On the other hand, gastrointestinal vagal afferents converge in the NTS of the brainstem. Neural projections from the NTS, in turn, carry signals to the hypothalamus. The ARC acts as an integrative center, with two major subpopulations of neurons influencing appetite, one of them coexpressing neuropeptide Y and agouti-related protein (AgRP) that increases food intake, whereas the other subpopulation coexpresses pro-opiomelanocortin (POMC) and cocaine and amphetamine-regulated transcript that inhibits food intake. AgRP antagonizes the effects of the POMC product, α-melanocyte-stimulating hormone (α-MSH). Both populations project to areas important in the regulation of food intake, including the hypothalamic paraventricular nucleus, which also receives important inputs from other hypothalamic nuclei.

Journal ArticleDOI
TL;DR: A combined spectroscopic, synthetic, and apparative study has allowed a more detailed mechanistic rationalization of several recently reported eosin Y-catalyzed aromatic substitutions at arenediazonium salts.
Abstract: A combined spectroscopic, synthetic, and apparative study has allowed a more detailed mechanistic rationalization of several recently reported eosin Y-catalyzed aromatic substitutions at arenediazonium salts. The operation of rapid acid–base equilibria, direct photolysis pathways, and radical chain reactions has been discussed on the basis of pH, solvent polarity, lamp type, absorption properties, and quantum yields. Determination of the latter proved to be an especially valuable tool for the distinction between radical chain and photocatalytic reactions.

Journal ArticleDOI
TL;DR: The increasing use of BA products since the year 2000 with an increase use of MODIS as a reference dataset is identified and a significant need for low spatial resolution and long time series data characterized with supplementary information concerning the accuracy in timing of the fire and reductions of omission/commission errors is presented.

Journal ArticleDOI
TL;DR: Overall, plant invasions increased N pools and accelerated fluxes, even when excluding N-fixing invaders, and it is shown that more functionally distant invaders occurring in mild climates are causing the strongest alterations to the N cycle.
Abstract: Exotic plant invasions can notably alter the nitrogen (N) cycle of ecosystems. However, there is large variation in the magnitude and direction of their impact that remains unexplained. We present a structured meta-analysis of 100 papers, covering 113 invasive plant species with 345 cases of invasion across the globe and reporting impacts on N cycle-related metrics. We aim to explain heterogeneity of impacts by considering methodological aspects, properties of the invaded site and phylogenetic and functional characteristics of the invaders and the natives. Overall, plant invasions increased N pools and accelerated fluxes, even when excluding N-fixing invaders. The impact on N pools depended mainly on functional differences and was greater when the invasive plants and the natives differed in N-fixation ability, plant height and plant/leaf habit. Furthermore, the impact on N fluxes was related mainly to climate, being greater under warm and moist conditions. Our findings show that more functionally distant invaders occurring in mild climates are causing the strongest alterations to the N cycle.

Journal ArticleDOI
TL;DR: In this paper, a review summarizes the recent trends and developments of infrared and Raman spectroscopy applied to the identification of explosives that have been published over the past decade focusing on the different fields where explosives were studied: homeland and international security, forensics, environmental, characterization of explosives, trace detection and fluorescence-free Raman analysis of explosives.
Abstract: This review summarizes the recent trends and developments of infrared and Raman spectroscopy applied to the identification of explosives that have been published over the past decade, focusing on the different fields where explosives were studied: homeland and international security, forensics, environmental, characterization of explosives, trace detection and fluorescence-free Raman analysis of explosives.

Journal ArticleDOI
TL;DR: In this paper, the Soil and Water Assessment Tool (SWAT) model was used to quantify the potential effects of various climate and land use change scenarios on catchment hydrology as well as the trophic state of a new kind of waterbody, a limno-reservoir (Pareja Limno-REServoir), created for environmental and recreational purposes.

Journal ArticleDOI
17 Apr 2014-PLOS ONE
TL;DR: The extent to which restoration increased biodiversity and ES in degraded wetlands depended primarily on the main agent of degradation, restoration actions, experimental design, and ecosystem type, in contrast, the choice of specific restoration actions alone explained most differences between restored and natural wetlands.
Abstract: Wetlands are valuable ecosystems because they harbor a huge biodiversity and provide key services to societies. When natural or human factors degrade wetlands, ecological restoration is often carried out to recover biodiversity and ecosystem services (ES). Although such restorations are routinely performed, we lack systematic, evidence-based assessments of their effectiveness on the recovery of biodiversity and ES. Here we performed a meta-analysis of 70 experimental studies in order to assess the effectiveness of ecological restoration and identify what factors affect it. We compared selected ecosystem performance variables between degraded and restored wetlands and between restored and natural wetlands using response ratios and random-effects categorical modeling. We assessed how context factors such as ecosystem type, main agent of degradation, restoration action, experimental design, and restoration age influenced post-restoration biodiversity and ES. Biodiversity showed excellent recovery, though the precise recovery depended strongly on the type of organisms involved. Restored wetlands showed 36% higher levels of provisioning, regulating and supporting ES than did degraded wetlands. In fact, wetlands showed levels of provisioning and cultural ES similar to those of natural wetlands; however, their levels of supporting and regulating ES were, respectively, 16% and 22% lower than in natural wetlands. Recovery of biodiversity and of ES were positively correlated, indicating a win-win restoration outcome. The extent to which restoration increased biodiversity and ES in degraded wetlands depended primarily on the main agent of degradation, restoration actions, experimental design, and ecosystem type. In contrast, the choice of specific restoration actions alone explained most differences between restored and natural wetlands. These results highlight the importance of comprehensive, multi-factorial assessment to determine the ecological status of degraded, restored and natural wetlands and thereby evaluate the effectiveness of ecological restorations. Future research on wetland restoration should also seek to identify which restoration actions work best for specific habitats.

Proceedings ArticleDOI
08 Jun 2014
TL;DR: DriveSafe is the first app for smartphones based on inbuilt sensors able to detect inattentive behaviors evaluating the quality of the driving at the same time and represents a new disruptive technology because it provides similar ADAS features that found in luxury cars.
Abstract: This paper presents DriveSafe, a new driver safety app for iPhones that detects inattentive driving behaviors and gives corresponding feedback to drivers, scoring their driving and alerting them in case their behaviors are unsafe. It uses computer vision and pattern recognition techniques on the iPhone to assess whether the driver is drowsy or distracted using the rear-camera, the microphone, the inertial sensors and the GPS. We present the general architecture of DriveSafe and evaluate its performance using data from 12 drivers in two different studies. The first one evaluates the detection of some inattentive driving behaviors obtaining an overall precision of 82% at 92% of recall. The second one compares the scores between DriveSafe vs the commercial AXA Drive app obtaining a better valuation to its operation. DriveSafe is the first app for smartphones based on inbuilt sensors able to detect inattentive behaviors evaluating the quality of the driving at the same time. It represents a new disruptive technology because, on the one hand, it provides similar ADAS features that found in luxury cars, and on the other hand, it presents a viable alternative for the “blackboxes” installed in vehicles by the insurance companies.

Journal ArticleDOI
TL;DR: In this paper, the authors present FIR [50-300 mu m]-CO luminosity relations (i.e., log L-FIR = alpha log L'(CO) + beta) for the full CO rotational ladder from J = 1-0 up to J = 13-12 for a sample of 62 local (z 10(11) L-circle dot) LIRGs using data from Herschel SPIRE-FTS and ground-based telescopes.
Abstract: We present FIR [50-300 mu m]-CO luminosity relations (i.e., log L-FIR = alpha log L'(CO) + beta) for the full CO rotational ladder from J = 1-0 up to J = 13-12 for a sample of 62 local (z 10(11) L-circle dot) using data from Herschel SPIRE-FTS and ground-based telescopes. We extend our sample to high redshifts (z > 1) by including 35 submillimeter selected dusty star forming galaxies from the literature with robust CO observations, and sufficiently well-sampled FIR/submillimeter spectral energy distributions (SEDs), so that accurate FIR luminosities can be determined. The addition of luminous starbursts at high redshifts enlarge the range of the FIR-CO luminosity relations toward the high-IR-luminosity end, while also significantly increasing the small amount of mid-J/high-J CO line data (J = 5-4 and higher) that was available prior to Herschel. This new data set (both in terms of IR luminosity and J-ladder) reveals linear FIR-CO luminosity relations (i.e., a similar or equal to 1) for J = 1-0 up to J = 5-4, with a nearly constant normalization (beta similar to 2). In the simplest physical scenario, this is expected from the (also) linear FIR-(molecular line) relations recently found for the dense gas tracer lines (HCN and CS), as long as the dense gas mass fraction does not vary strongly within our (merger/starburst)-dominated sample. However, from J = 6-5 and up to the J = 13-12 transition, we find an increasingly sublinear slope and higher normalization constant with increasing J. We argue that these are caused by a warm (similar to 100 K) and dense (>10(4) cm(-3)) gas component whose thermal state is unlikely to be maintained by star-formation-powered far-UV radiation fields (and thus is no longer directly tied to the star formation rate). We suggest that mechanical heating (e.g., supernova-driven turbulence and shocks), and not cosmic rays, is the more likely source of energy for this component. The global CO spectral line energy distributions, which remain highly excited from J = 6-5 up to J = 13-12, are found to be a generic feature of the (U)LIRGs in our sample, and further support the presence of this gas component.

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TL;DR: This paper presents a novel bioinspired algorithm to tackle complex optimization problems: the coral reefs optimization (CRO) algorithm, which artificially simulates a coral reef and produces a robust metaheuristic algorithm shown to be powerful for solving hard optimization problems.
Abstract: This paper presents a novel bioinspired algorithm to tackle complex optimization problems: the coral reefs optimization (CRO) algorithm. The CRO algorithm artificially simulates a coral reef, where different corals (namely, solutions to the optimization problem considered) grow and reproduce in coral colonies, fighting by choking out other corals for space in the reef. This fight for space, along with the specific characteristics of the corals' reproduction, produces a robust metaheuristic algorithm shown to be powerful for solving hard optimization problems. In this research the CRO algorithm is tested in several continuous and discrete benchmark problems, as well as in practical application scenarios (i.e., optimum mobile network deployment and off-shore wind farm design). The obtained results confirm the excellent performance of the proposed algorithm and open line of research for further application of the algorithm to real-world problems.

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TL;DR: The experiments carried out have shown that the CRO–ELM approach is able to obtain an accurate prediction of the daily global radiation, better than the classical ELM, and the Support Vector Regression algorithm.

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TL;DR: In this paper, a comprehensive fire risk assessment system is proposed, which makes extensive use of geographic information technology to evaluate risk conditions, including human factors, lightning probability and fuel moisture content of both dead and live fuels.
Abstract: Fire risk assessment should take into account the most relevant components associated to fire occurrence. To estimate when and where the fire will produce undesired effects, we need to model both (a) fire ignition and propagation potential and (b) fire vulnerability. Following these ideas, a comprehensive fire risk assessment system is proposed in this paper,whichmakesextensiveuseofgeographicinformationtechnologiestoofferaspatiallyexplicitevaluationoffirerisk conditions. The paper first describes the conceptual model, then the methods to generate the different input variables, the approachestomergethosevariablesintosyntheticriskindicesandfinallythevalidationoftheoutputs.Themodelhasbeen applied at a national level for the whole Spanish Iberian territory at 1-km 2 spatial resolution. Fire danger included human factors, lightning probability, fuel moisture content of both dead and live fuels and propagation potential. Fire vulnerability was assessed by analysing values-at-risk and landscape resilience. Each input variable included a particular accuracy assessment, whereas the synthetic indices were validated using the most recent fire statistics available. Significant relations (P,0.001) with fire occurrence were found for the main synthetic danger indices, particularly for those associated to fuel moisture content conditions.