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Institution

University of Alcalá

EducationAlcalá de Henares, Spain
About: University of Alcalá is a education organization based out in Alcalá de Henares, Spain. It is known for research contribution in the topics: Population & Receptor. The organization has 10795 authors who have published 20718 publications receiving 410089 citations. The organization is also known as: University of Alcala & University of Alcala de Henares.


Papers
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Journal ArticleDOI
TL;DR: The markers most frequently used to analyze cell death in protozoan parasites are discussed, paying special attention to changes in cell morphology, mitochondrial activity, chromatin structure and plasma membrane structure/permeability.
Abstract: The execution of the apoptotic death program in metazoans is characterized by a sequence of morphological and biochemical changes that include cell shrinkage, presentation of phosphatidylserine at the cell surface, mitochondrial alterations, chromatin condensation, nuclear fragmentation, membrane blebbing and the formation of apoptotic bodies. Methodologies for measuring apoptosis are based on these markers. Except for membrane blebbing and formation of apoptotic bodies, all other events have been observed in most protozoan parasites undergoing cell death. However, while techniques exist to detect these markers, they are often optimised for metazoan cells and therefore may not pick up subtle differences between the events occurring in unicellular organisms and multi-cellular organisms. In this review we discuss the markers most frequently used to analyze cell death in protozoan parasites, paying special attention to changes in cell morphology, mitochondrial activity, chromatin structure and plasma membrane structure/permeability. Regarding classical regulators/executors of apoptosis, we have reviewed the present knowledge of caspase-like and nuclease activities.

122 citations

Journal ArticleDOI
TL;DR: COMBINE analysis is validated as a powerful methodology for predicting binding affinities and pharmacological activities of congeneric ligands that bind to a common receptor.
Abstract: A comparative binding energy (COMBINE) analysis (Ortiz et al. J. Med. Chem. 1995, 38, 2681−2691) has been performed on a training set of 33 HIV-1 protease inhibitors, and the resulting regression models have been validated using an additional external set of 16 inhibitors. This data set was originally reported by Holloway et al. (J. Med. Chem. 1995, 38, 305−317), who showed the usefulness of molecular mechanics interaction energies for predicting the activity of novel HIV-1 protease inhibitors within the framework of the MM2X force field and linear regression techniques. We first used the AMBER force field on the same set of three-dimensional structures to check up on any possible force-field dependencies. In agreement with the previous findings, the calculated raw ligand−receptor interaction energies were highly correlated with the inhibitory activities (r2 = 0.81), and the linear regression model relating both magnitudes had an acceptable predictive ability both in internal validation tests (q2 = 0.79, ...

122 citations

Journal ArticleDOI
TL;DR: A method to predict future pedestrian paths, poses, and intentions up to 1 s in advance based on balanced Gaussian process dynamical models (B-GPDMs), which reduce the 3-D time-related information extracted from key points or joints placed along pedestrian bodies into low-dimensional spaces.
Abstract: According to several reports published by worldwide organizations, thousands of pedestrians die in road accidents every year. Due to this fact, vehicular technologies have been evolving with the intent of reducing these fatalities. This evolution has not finished yet, since, for instance, the predictions of pedestrian paths could improve the current automatic emergency braking systems. For this reason, this paper proposes a method to predict future pedestrian paths, poses, and intentions up to 1 s in advance. This method is based on balanced Gaussian process dynamical models (B-GPDMs), which reduce the 3-D time-related information extracted from key points or joints placed along pedestrian bodies into low-dimensional spaces. The B-GPDM is also capable of inferring future latent positions and reconstruct their associated observations. However, learning a generic model for all kinds of pedestrian activities normally provides less accurate predictions. For this reason, the proposed method obtains multiple models of four types of activity, i.e., walking, stopping, starting, and standing, and selects the most similar model to estimate future pedestrian states. This method detects starting activities 125 ms after the gait initiation with an accuracy of 80% and recognizes stopping intentions 58.33 ms before the event with an accuracy of 70%. Concerning the path prediction, the mean error for stopping activities at a time-to-event (TTE) of 1 s is 238.01 ± 206.93 mm and, for starting actions, the mean error at a TTE of 0 s is 331.93 ± 254.73 mm.

122 citations

Journal ArticleDOI
TL;DR: This paper presents the design, implementation, and test of an industrial multiprocessor controller based on a floating-point digital signal processor (DSP) and a field-programmable gate array, which operate cooperatively.
Abstract: New energy concepts such as distributed power generation systems (DPGSs) are changing the face of electric distribution and transmission. Power electronics researchers try to apply new electronic controller solutions with the capacity of implementing new and more complex control algorithms combined with internal high-speed communication interfaces. Thus, it is possible to monitor, store, and transfer a large number of internal variables that can be sent online to local or remote hosts in order to take new set points of different generation units. With this objective, this paper presents the design, implementation, and test of an industrial multiprocessor controller based on a floating-point digital signal processor (DSP) and a field-programmable gate array, which operate cooperatively. The communication architecture, which has been added to the proposed electronic solution, consists of a universal serial bus (USB), implemented with a minimum use of the DSP core, and a controller area network (CAN) bus that permits distributed control. Although the proposed system can be readily applied to any DPGS, in this paper, it is focused on a 150-kVA back-to-back three-level neutral-point-clamped voltage source converter for wind turbine applications.

122 citations

Journal ArticleDOI
TL;DR: In this article, the authors used five criteria for identifying areas of high-value diversity: species richness, rarity, vulnerability, a combined index of biodiversity, and a Standardized Biodiversity Index that measured all four taxa together.

122 citations


Authors

Showing all 10907 results

NameH-indexPapersCitations
José Luis Zamorano105695133396
Jesús F. San Miguel9752744918
Sebastián F. Sánchez9662932496
Javier P. Gisbert9599033726
Luis M. Ruilope9484197778
Luis M. Garcia-Segura8848427077
Alberto Orfao8559737670
Amadeo R. Fernández-Alba8331821458
Rafael Luque8069328395
Francisco Rodríguez7974824992
Andrea Negri7924235311
Rafael Cantón7857529702
David J. Grignon7830123119
Christophe Baudouin7455322068
Josep M. Argilés7331019675
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20251
20243
202375
2022166
20211,660
20201,532