Institution
University of Alcalá
Education•Alcalá de Henares, Spain•
About: University of Alcalá is a education organization based out in Alcalá de Henares, Spain. It is known for research contribution in the topics: Population & Receptor. The organization has 10795 authors who have published 20718 publications receiving 410089 citations. The organization is also known as: University of Alcala & University of Alcala de Henares.
Topics: Population, Receptor, Band-pass filter, Species richness, Dendrimer
Papers published on a yearly basis
Papers
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TL;DR: It was found that review readability had a greater effect on the helpfulness ratio of a review than its length; in addition, extremely helpful reviews received a higher score than those considered less helpful.
450 citations
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Iran University of Medical Sciences1, Tehran University of Medical Sciences2, Tabriz University of Medical Sciences3, Shahid Beheshti University of Medical Sciences and Health Services4, Kermanshah University of Medical Sciences5, University of Alcalá6, NewYork–Presbyterian Hospital7, Yale University8, Universidad Católica San Antonio de Murcia9, Brigham and Women's Hospital10, Virginia Commonwealth University11, University of Nebraska Medical Center12, Icahn School of Medicine at Mount Sinai13, University of Liverpool14, Aalborg University15
TL;DR: In this paper, the authors evaluated the effects of intermediate-dose vs standard-dose prophylactic anticoagulation among patients with COVID-19 admitted to the intensive care unit (ICU).
Abstract: Importance Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis. Objective To evaluate the effects of intermediate-dose vs standard-dose prophylactic anticoagulation among patients with COVID-19 admitted to the intensive care unit (ICU). Design, Setting, and Participants Multicenter randomized trial with a 2 × 2 factorial design performed in 10 academic centers in Iran comparing intermediate-dose vs standard-dose prophylactic anticoagulation (first hypothesis) and statin therapy vs matching placebo (second hypothesis; not reported in this article) among adult patients admitted to the ICU with COVID-19. Patients were recruited between July 29, 2020, and November 19, 2020. The final follow-up date for the 30-day primary outcome was December 19, 2020. Interventions Intermediate-dose (enoxaparin, 1 mg/kg daily) (n = 276) vs standard prophylactic anticoagulation (enoxaparin, 40 mg daily) (n = 286), with modification according to body weight and creatinine clearance. The assigned treatments were planned to be continued until completion of 30-day follow-up. Main Outcomes and Measures The primary efficacy outcome was a composite of venous or arterial thrombosis, treatment with extracorporeal membrane oxygenation, or mortality within 30 days, assessed in randomized patients who met the eligibility criteria and received at least 1 dose of the assigned treatment. Prespecified safety outcomes included major bleeding according to the Bleeding Academic Research Consortium (type 3 or 5 definition), powered for noninferiority (a noninferiority margin of 1.8 based on odds ratio), and severe thrombocytopenia (platelet count Results Among 600 randomized patients, 562 (93.7%) were included in the primary analysis (median [interquartile range] age, 62 [50-71] years; 237 [42.2%] women). The primary efficacy outcome occurred in 126 patients (45.7%) in the intermediate-dose group and 126 patients (44.1%) in the standard-dose prophylaxis group (absolute risk difference, 1.5% [95% CI, −6.6% to 9.8%]; odds ratio, 1.06 [95% CI, 0.76-1.48];P = .70). Major bleeding occurred in 7 patients (2.5%) in the intermediate-dose group and 4 patients (1.4%) in the standard-dose prophylaxis group (risk difference, 1.1% [1-sided 97.5% CI, −∞ to 3.4%]; odds ratio, 1.83 [1-sided 97.5% CI, 0.00-5.93]), not meeting the noninferiority criteria (Pfor noninferiority >.99). Severe thrombocytopenia occurred only in patients assigned to the intermediate-dose group (6 vs 0 patients; risk difference, 2.2% [95% CI, 0.4%-3.8%];P = .01). Conclusions and Relevance Among patients admitted to the ICU with COVID-19, intermediate-dose prophylactic anticoagulation, compared with standard-dose prophylactic anticoagulation, did not result in a significant difference in the primary outcome of a composite of adjudicated venous or arterial thrombosis, treatment with extracorporeal membrane oxygenation, or mortality within 30 days. These results do not support the routine empirical use of intermediate-dose prophylactic anticoagulation in unselected patients admitted to the ICU with COVID-19. Trial Registration ClinicalTrials.gov Identifier:NCT04486508
447 citations
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TL;DR: In this paper, the authors trace the content, scope and relatively short history of modern social innovation research across disciplines by applying network and bibliometric analyses, and explore their relevance to innovation studies.
447 citations
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University of Birmingham1, Monash University2, University of Oxford3, University of Alcalá4, Hull York Medical School5, National Institutes of Health6, Birmingham City Hospital7, University of Warwick8, Sahlgrenska University Hospital9, Oslo University Hospital10, University of Alberta11, Castle Hill Hospital12, University of East Anglia13
TL;DR: Based on the findings, β blockers should not be used preferentially over other rate-control medications and not regarded as standard therapy to improve prognosis in patients with concomitant heart failure and atrial fibrillation.
447 citations
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TL;DR: This paper reviewed the Spanish experience of using temporary employment contracts for regular jobs since 1984, focusing on the role of fixed-term contracts with low severance pay, which have substituted for reform of employment protection legislation for permanent contracts.
Abstract: We review some lessons from the Spanish experience of using temporary employment contracts for regular jobs since 1984 The focus is on the role of fixed-term contracts with low severance pay, which have substituted for reform of employment protection legislation for permanent contracts We consider the main findings about this reform on the Spanish labour market in the light of the main theoretical implications derived from models dealing with dual labour markets, and address why the incidence of temporary work has remained highly persistent, around 33% of salaried employment, in the 1990s, despite several reforms aimed at reducing it
443 citations
Authors
Showing all 10907 results
Name | H-index | Papers | Citations |
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José Luis Zamorano | 105 | 695 | 133396 |
Jesús F. San Miguel | 97 | 527 | 44918 |
Sebastián F. Sánchez | 96 | 629 | 32496 |
Javier P. Gisbert | 95 | 990 | 33726 |
Luis M. Ruilope | 94 | 841 | 97778 |
Luis M. Garcia-Segura | 88 | 484 | 27077 |
Alberto Orfao | 85 | 597 | 37670 |
Amadeo R. Fernández-Alba | 83 | 318 | 21458 |
Rafael Luque | 80 | 693 | 28395 |
Francisco Rodríguez | 79 | 748 | 24992 |
Andrea Negri | 79 | 242 | 35311 |
Rafael Cantón | 78 | 575 | 29702 |
David J. Grignon | 78 | 301 | 23119 |
Christophe Baudouin | 74 | 553 | 22068 |
Josep M. Argilés | 73 | 310 | 19675 |