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Institution

University of Alcalá

EducationAlcalá de Henares, Spain
About: University of Alcalá is a education organization based out in Alcalá de Henares, Spain. It is known for research contribution in the topics: Population & Receptor. The organization has 10795 authors who have published 20718 publications receiving 410089 citations. The organization is also known as: University of Alcala & University of Alcala de Henares.


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Journal ArticleDOI
TL;DR: The selective hepatic activation of the apelin system, together with the drop in fibrosis and neoangiogenesis and the improvement in cardiovascular and excretory function resulting from apelin receptor blockade, points to the hepatic apel system as a novel therapeutic target in liver disease.

120 citations

Journal ArticleDOI
TL;DR: Intraspecific variability of phenology was found to be low among populations of the same species, and it is hypothesised that type I species possess deeper roots, rely on predictable water sources and occupy mature stages of succession and type II species, on the contrary, are expected to depend on more unpredictable water sources, to possess shallower root systems and to colonise earlier stages ofsuccess.
Abstract: The phenological pattern of fifteen Mediterranean phanaerophytes has been studied in several sites per species, by visiting the populations on a monthly basis over a one year period. Studied phenophases were dolichoblast vegetative growth (DVG), flower bud formation (FBF), flowering (F), fruit setting (FS), seed dispersal (SD), and leaf shedding of dolichoblasts (LSD). Considering the whole set of species, DVG, FBF and F took place mainly in spring, FS in summer, SD in autumn and LSD in summer and in autumn. Interspecific comparisons showed a wide variety of phenological patterns, which have been sorted according to the 'phenophase sequence index' (PSI). This index quantified the degree of superposition between DVG, FBF and F, and it constituted the basis for a functional classification of phenological patterns. Two groups were established. The 'type I' group was characterised by the concentration of phenophases in a short time in spring, while the 'type II' by the protraction and sequential arrangement of phenophases. Type I species performed most of their functions during a resource surplus period, but they have to face an intraplant competition between vegetative and reproductive demands. Type II species avoided intraplant competition but had to develop part of DVG, FBF and F during sub-optimal periods. It is hypothesised that type I species possess deeper roots, rely on predictable water sources and occupy mature stages of succession. Type II species, on the contrary, are expected to depend on more unpredictable water sources, to possess shallower root systems and to colonise earlier stages of succession. Intraspecific variability of phenology was found to be low among populations of the same species. Bud structure, which is a phylogenetic trait, may exert important constraints on plant phenology. Nomenclature: Flora Iberica – Castroviejo et al. 1986–1997, Flora Europaea – Tutin et al. 1964–1980.

120 citations

Journal ArticleDOI
A. Aab1, P. Abreu2, Marco Aglietta3, Eun-Joo Ahn4  +507 moreInstitutions (77)
TL;DR: The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers and allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.
Abstract: We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.

120 citations

Journal ArticleDOI
TL;DR: Results indicate that MMP-2 may be involved in the TF matrix degradative process in patients with direct hernia, suggesting a genetic defect or irreversible change as the origin of this pathology rather than environmental factors, which may later participate in the development of the hernial process.
Abstract: Inguinal hernias are among the disorders that most frequently require surgery: their repair accounts for 10% to 15% of all general surgical procedures. 1 Although the cause remains unknown, it has been established that the integrity of the abdominal wall in the groin area is dependent on the transversalis fascia (TF), the oblique orientation of the inguinal canal, and a sphincterlike structure of the internal ring. 2 Despite numerous predisposing factors, including anatomical features (persistence of the peritoneal-vaginal conduit, high insertion point of the transverse arch) and those associated with other diseases (obesity, chronic obstructive pulmonary disease, constipation), the underlying cause of the development of the different types of hernias is of a biologic nature. Research aimed at evaluating the role played by biologic factors has centered on possible alterations in connective tissue metabolism. This idea is also supported by the fact that diseases such as Marfan and Ehlers-Danlos syndromes, cutis laxa, osteogenesis imperfecta, 3 and congenital hip dislocation 4 have been associated with hernial processes. Tissue specimens from patients with hernias for this type of experimental study include the abdominal anterior rectus muscle sheath, 5 cremaster, hernial sac, 6 and even skin tissue. 7 The expression pattern of certain types of collagen 8 and certain enzyme dysfunctions 9 have also been the subject of several of these studies. Concerned about the cause of hernias, we have conducted several investigations on TF biopsy specimens from patients with hernias. We correlated the ultrastructural features of the TF with collagen activity and degradation through the study of certain metalloproteinases (MMPs) and observed an increase in MMP-2 expression in TF specimens from patients with direct hernias. 10 This enzyme degrades and participates in the turnover of the extracellular matrix, acting on certain types of collagen and elastin. Its expression is enhanced in processes such as genitourinary prolapse 11 and aortic aneurysm. 12,13 Further, it has been reported that patients with this last pathology have an increased incidence of hernias. 14,15 These findings prompted us to propose a hypothesis for the behavior of MMP-2 in TF specimens of patients with hernias, based on the possibility of a similar mechanism that might explain why in some patients the posterior wall of the inguinal canal of the TF remains unaltered, and in others it presents defects that lead to hernial processes. To this end, we designed an in vitro model using cultured fibroblasts from the TF to determine whether the modifications in MMP expression found in tissue are maintained in culture. If this were the case, it could point to a genetic predisposing factor for this pathology, and thus hernia types showing some alteration at the level of the TF could be candidates for primary repair with a prosthetic material in a effort to prevent future relapses.

120 citations

Journal ArticleDOI
TL;DR: In this paper, a global burned area (BA) algorithm based on MERIS imagery along with the assessment of the global BA results for three years (2006-2008) was developed within the Fire Disturbance project under the European Space Agency Climate Change Initiative programme, which aimed to generate long-term BA information for climate models.

120 citations


Authors

Showing all 10907 results

NameH-indexPapersCitations
José Luis Zamorano105695133396
Jesús F. San Miguel9752744918
Sebastián F. Sánchez9662932496
Javier P. Gisbert9599033726
Luis M. Ruilope9484197778
Luis M. Garcia-Segura8848427077
Alberto Orfao8559737670
Amadeo R. Fernández-Alba8331821458
Rafael Luque8069328395
Francisco Rodríguez7974824992
Andrea Negri7924235311
Rafael Cantón7857529702
David J. Grignon7830123119
Christophe Baudouin7455322068
Josep M. Argilés7331019675
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20251
20243
202375
2022166
20211,660
20201,532