University of Alcalá

About: University of Alcalá is a education organization based out in Alcalá de Henares, Spain. It is known for research contribution in the topics: Population & Context (language use). The organization has 10795 authors who have published 20718 publications receiving 410089 citations. The organization is also known as: University of Alcala & University of Alcala de Henares.

The Benefits of Dense Stereo for Pedestrian Detection

Abstract: This paper presents a novel pedestrian detection system for intelligent vehicles. We propose the use of dense stereo for both the generation of regions of interest and pedestrian classification. Dense stereo allows the dynamic estimation of camera parameters and the road profile, which, in turn, provides strong scene constraints on possible pedestrian locations. For classification, we extract spatial features (gradient orientation histograms) directly from dense depth and intensity images. Both modalities are represented in terms of individual feature spaces, in which discriminative classifiers (linear support vector machines) are learned. We refrain from the construction of a joint feature space but instead employ a fusion of depth and intensity on the classifier level. Our experiments involve challenging image data captured in complex urban environments (i.e., undulating roads and speed bumps). Our results show a performance improvement by up to a factor of 7.5 at the classification level and up to a factor of 5 at the tracking level (reduction in false alarms at constant detection rates) over a system with static scene constraints and intensity-only classification.

Variable expression of activation-linked surface antigens on human mast cells in health and disease.

Abstract: Mast cells (MC) are multipotent effector cells of the immune system. They contain an array of biologically active mediator substances in their granules. MC also express a number of functionally important cell surface antigens, including stem cell factor receptor (SCFR=kit=CD117), high affinity IgER (FcepsilonRI), or CSaR (CD88). Respective ligands can induce or promote degranulation, migration, or cytokine production. Other integral surface molecules can mediate adhesion or cell aggregation. Recent data suggest that a number of critical molecules are variably expressed on the surface of human MC. In fact, depending on the environment (organ), stage of cell maturation, type of disease, and other factors, MC express variable amounts of activation-linked antigens (CD25, CD63, CD69, CD88), cell recognition molecules (CD2, CD11, CD18, CD50, CD54), or cytokine receptors. At present, however, little is known about the mechanisms and regulation of expression of such antigens. The present article gives an overview of MC phenotypes in health and disease, and attempts to provide explanations for the phenotypic variability of MC.