Institution
University of Amsterdam
Education•Amsterdam, Noord-Holland, Netherlands•
About: University of Amsterdam is a education organization based out in Amsterdam, Noord-Holland, Netherlands. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 59309 authors who have published 140894 publications receiving 5984137 citations. The organization is also known as: UvA & Universiteit van Amsterdam.
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Papers
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01 Jan 1998TL;DR: In this paper, the authors present a cross-lingual alignment of EuroWordNet with an Inter-Lingual-Index (ILI-Index) based on crosslingual similarity measure.
Abstract: Introduction to EuroWordNet P. Vossen. The Linguistic Design of the EuroWordNet Database A. Alonge, et al. Compatibility in Interpretation of Relations in EuroWordNet P. Vossen, et al. A Semantic Network of English: The Mother of All WordNets C. Fellbaum. Cross-Linguistic Alignment of Wordnets with an Inter-Lingual-Index W. Peters, et al.
852 citations
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TL;DR: 3-Methyladenine, which is commonly used as a specific inhibitor of autophagic sequestration, was an inhibitor of phosphatidylinositol 3-kinase, thus providing a target for its action.
Abstract: Recent studies indicate that phosphatidylinositol 3-kinase is essential in the regulation of many processes dependent on membrane flow. Autophagy is a complex pathway in which cell material, including proteins, can be degraded. Membrane flow plays a pivotal role in this process. To find out whether phosphatidylinositol 3-kinase is also required for autophagy, we tested the effects on autophagy of two structurally unrelated phosphatidylinositol 3-kinase inhibitors, wortmannin and 2-(4-morpholinyl)-8-phenylchromone (LY294002). The addition of low concentrations of each of these inhibitors to incubations of hepatocytes in the absence of amino acids resulted in a strong inhibition of proteolysis. The antiproteolytic effect of wortmannin (IC50 30 nM) and LY294002 (IC50 10 mu M) was accompanied by inhibition of autophagic sequestration and not by an increase in lysosomal pH or a decrease in intracellular ATP. No further inhibition of proteolysis by the two compounds was observed when autophagy was already maximally inhibited by high concentrations of amino acids. 3-Methyladenine, which is commonly used as a specific inhibitor of autophagic sequestration, was an inhibitor of phosphatidylinositol 3-kinase, thus providing a target for its action. It is proposed that phosphatidylinositol 3-kinase activity is required for autophagy. 3-Methyladenine inhibits autophagy by inhibition of this enzyme.
851 citations
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The Chinese University of Hong Kong1, University of Pittsburgh2, Pontifícia Universidade Católica do Rio Grande do Sul3, Sanjay Gandhi Post Graduate Institute of Medical Sciences4, University of Queensland5, Leiden University Medical Center6, University of Missouri7, Boston Children's Hospital8, University of Amsterdam9
TL;DR: In this article, the authors presented the results of a study at the University of Medicine and Therapeutics of the Chinese University of Hong Kong, Hong Kong and University of Pittsburgh School of Medicine.
Abstract: Department of Medicine and Therapeutics,1 Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; University of Pittsburgh School of Medicine,2 Pittsburgh, PA, USA; Faculdade de Enfermagem, Nutrição e Fisioterapia,3 Pontifícia Universidade Católica do Rio Grande do Sul, Brazil; Sanjay Gandhi Postgraduate Institute of Medical Sciences,4 Lucknow, India; Department of Nephrology,5 Princess Alexandra Hospital, and School of Medicine, University of Queensland, Brisbane, Australia; Department of Medical Microbiology,6 Leiden University Medical Center, Leiden, The Netherlands; Centre for Kidney Diseases,7 Mount Elizabeth Medical Centre, Singapore; Section of Infectious Disease,8 Department of Internal Medicine, University of Missouri-Columbia School of Medicine, Columbia, MO, USA; Pediatric Nephrology Division,9 University Children’s Hospital, Heidelberg, Germany; Dianet Dialysis Centers,10 Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
847 citations
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TL;DR: In this paper, it was shown that B-model topological strings on local Calabi-Yau threefolds are large-N duals of matrix models, which in the planar limit naturally give rise to special geometry.
846 citations
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TL;DR: The authors present OIL, a proposal for a joint standard for specifying and exchanging ontologies, which is needed for knowledge sharing and reuse on the Semantic Web.
Abstract: Researchers in artificial intelligence first developed ontologies to facilitate knowledge sharing and reuse. Ontologies play a major role in supporting information exchange across various networks. A prerequisite for such a role is the development of a joint standard for specifying and exchanging ontologies. The authors present OIL, a proposal for such a standard. Ontologies applied to the World Wide Web are creating the Semantic Web.
844 citations
Authors
Showing all 59759 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard A. Flavell | 231 | 1328 | 205119 |
Scott M. Grundy | 187 | 841 | 231821 |
Stuart H. Orkin | 186 | 715 | 112182 |
Kenneth C. Anderson | 178 | 1138 | 126072 |
David A. Weitz | 178 | 1038 | 114182 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Michael Kramer | 167 | 1713 | 127224 |
Nicholas J. White | 161 | 1352 | 104539 |
Lex M. Bouter | 158 | 767 | 103034 |
Wolfgang Wagner | 156 | 2342 | 123391 |
Jerome I. Rotter | 156 | 1071 | 116296 |
David Cella | 156 | 1258 | 106402 |
David Eisenberg | 156 | 697 | 112460 |
Naveed Sattar | 155 | 1326 | 116368 |