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Institution

University of Amsterdam

EducationAmsterdam, Noord-Holland, Netherlands
About: University of Amsterdam is a education organization based out in Amsterdam, Noord-Holland, Netherlands. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 59309 authors who have published 140894 publications receiving 5984137 citations. The organization is also known as: UvA & Universiteit van Amsterdam.


Papers
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Journal ArticleDOI
TL;DR: Recording neuron ensembles in the rat medial prefrontal cortex to study memory trace reactivation during SWS following learning and execution of cross-modal strategy shifts found that learning influenced which patterns were most strongly encoded and successively reactivated in the hippocampal/prefrontal network.
Abstract: Slow-wave sleep (SWS) is important for memory consolidation. During sleep, neural patterns reflecting previously acquired information are replayed. One possible reason for this is that such replay exchanges information between hippocampus and neocortex, supporting consolidation. We recorded neuron ensembles in the rat medial prefrontal cortex (mPFC) to study memory trace reactivation during SWS following learning and execution of cross-modal strategy shifts. In general, reactivation of learning-related patterns occurred in distinct, highly synchronized transient bouts, mostly simultaneous with hippocampal sharp wave/ripple complexes (SPWRs), when hippocampal ensemble reactivation and cortico-hippocampal interaction is enhanced. During sleep following learning of a new rule, mPFC neural patterns that appeared during response selection replayed prominently, coincident with hippocampal SPWRs. This was learning dependent, as the patterns appeared only after rule acquisition. Therefore, learning, or the resulting reliable reward, influenced which patterns were most strongly encoded and successively reactivated in the hippocampal/prefrontal network.

707 citations

Journal ArticleDOI
TL;DR: In this paper, the authors analyzed the relation between allocation, wages and job satisfaction, and found that satisfaction with the job content is the main factor explaining overall job satisfaction; the effects of individual and job characteristics on job satisfaction differ by the aspect of the job considered; and skill mismatches do not seem to affect job satisfaction.
Abstract: Using data for The Netherlands, this paper analyzes the relation between allocation, wages and job satisfaction. Five conclusions emerge from the empirical analysis: satisfaction with the job content is the main factor explaining overall job satisfaction; the effects of individual and job characteristics on job satisfaction differ by the aspect of the job considered; the response to a general question on job satisfaction differs from the response to questions on satisfaction with different aspects of the job; it is relevant to consider the joint relation between wages and job satisfaction; and skill mismatches do not seem to affect job satisfaction.

706 citations

Proceedings Article
01 Jan 2018
TL;DR: In this article, a collection of non-negative stochastic gates, which collectively determine which weights to set to zero, is proposed to prune the network during training by encouraging weights to become exactly zero.
Abstract: We propose a practical method for L0 norm regularization for neural networks:pruning the network during training by encouraging weights to become exactly zero. Such regularization is interesting since (1) it can greatly speed up training and inference, and (2) it can improve generalization. AIC and BIC, well-known model selection criteria, are special cases of L0 regularization. However, since the L0 norm of weights is non-differentiable, we cannot incorporate it directly as a regularization term in the objective function. We propose a solution through the inclusion of a collection of non-negative stochastic gates, which collectively determine which weights to set to zero. We show that, somewhat surprisingly,for certain distributions over the gates, the expected L0 regularized objective is differentiable with respect to the distribution parameters. We further propose the hard concrete distribution for the gates, which is obtained by “stretching” a binary concrete distribution and then transforming its samples with a hard-sigmoid. The parameters of the distribution over the gates can then be jointly optimized with the original network parameters. As a result our method allows for straightforward and efficient learning of model structures with stochastic gradient descent and allows for conditional computation in a principled way. We perform various experiments to demonstrate the effectiveness of the resulting approach and regularizer.

704 citations

Journal ArticleDOI
TL;DR: The metabolic phenotype of mice treated with SRT1720, a specific and potent synthetic activator of SIRT1 that is devoid of direct action on AMPK that robustly enhances endurance running performance and strongly protects from diet-induced obesity and insulin resistance by enhancing oxidative metabolism in skeletal muscle, liver, and brown adipose tissue is reported.

702 citations


Authors

Showing all 59759 results

NameH-indexPapersCitations
Richard A. Flavell2311328205119
Scott M. Grundy187841231821
Stuart H. Orkin186715112182
Kenneth C. Anderson1781138126072
David A. Weitz1781038114182
Dorret I. Boomsma1761507136353
Brenda W.J.H. Penninx1701139119082
Michael Kramer1671713127224
Nicholas J. White1611352104539
Lex M. Bouter158767103034
Wolfgang Wagner1562342123391
Jerome I. Rotter1561071116296
David Cella1561258106402
David Eisenberg156697112460
Naveed Sattar1551326116368
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023198
2022698
20219,648
20208,534
20197,822
20186,407