Institution
University of Amsterdam
Education•Amsterdam, Noord-Holland, Netherlands•
About: University of Amsterdam is a education organization based out in Amsterdam, Noord-Holland, Netherlands. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 59309 authors who have published 140894 publications receiving 5984137 citations. The organization is also known as: UvA & Universiteit van Amsterdam.
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662 citations
TL;DR: In this paper, personal initiative, a concept akin to entrepreneurship and organizational spontaneity, was compared in East and West Germany and the differences were hypothesized to be the results of occupational socialization, particularly of work control and complexity rather than of a selection effect.
Abstract: Personal initiative, a concept akin to entrepreneurship and organizational spontaneity, was compared in East and West Germany. Differences were hypothesized to be the results of occupational socialization, particularly of work control and complexity, rather than of a selection effect. A representative longitudinal study was conducted in the East and a cross-sectional study in the West. Lower initiative at work was found in the East; control and complexity affected changes in initiative. The results speak for socialization and against selection.
660 citations
TL;DR: In this paper, the authors identify Hobit and Blimp1 as central regulators of a universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations, including NKT cells and liver-resident NK cells.
Abstract: Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.
660 citations
TL;DR: The fluxes through the autophagic and protein synthetic pathways are regulated in an opposite manner by the degree to which S6 is phosphorylated, which concludes that inhibition of autophagy and phosphorylation of S6 are under the same signal transduction pathway.
660 citations
King's College London1, University of Cambridge2, University of Leicester3, Catholic University of the Sacred Heart4, HealthPartners5, Tan Tock Seng Hospital6, Nanyang Technological University7, University of Southampton8, University of Miami9, University of Amsterdam10, Centre national de la recherche scientifique11, Anschutz Medical Campus12, Monash University13, Imperial College London14, State University of Campinas15, The Chinese University of Hong Kong16, Peking University17
TL;DR: An international panel of experts in the field of diabetes and endocrinology is formed to provide some guidance and practical recommendations for the management of diabetes during the COVID-19 pandemic.
659 citations
Authors
Showing all 59759 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Richard A. Flavell | 231 | 1328 | 205119 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Kenneth C. Anderson | 178 | 1138 | 126072 |
| David A. Weitz | 178 | 1038 | 114182 |
| Dorret I. Boomsma | 176 | 1507 | 136353 |
| Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
| Michael Kramer | 167 | 1713 | 127224 |
| Nicholas J. White | 161 | 1352 | 104539 |
| Lex M. Bouter | 158 | 767 | 103034 |
| Wolfgang Wagner | 156 | 2342 | 123391 |
| Jerome I. Rotter | 156 | 1071 | 116296 |
| David Cella | 156 | 1258 | 106402 |
| David Eisenberg | 156 | 697 | 112460 |
| Naveed Sattar | 155 | 1326 | 116368 |