Institution
University of Amsterdam
Education•Amsterdam, Noord-Holland, Netherlands•
About: University of Amsterdam is a education organization based out in Amsterdam, Noord-Holland, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 59309 authors who have published 140894 publications receiving 5984137 citations. The organization is also known as: UvA & Universiteit van Amsterdam.
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TL;DR: There is need for more methodologically sound studies that incorporate head-to-head comparisons of health care providers and significant others as proxy raters and employ well-validated quality-of-life measures and employ a longitudinal design in order to examine the effect of changes in patients' health status over time on the ability of proxies to provide valid quality- of-life assessments.
1,039 citations
TL;DR: How technological advances have enabled the detection of neurofilament proteins in the blood is considered, and how these proteins consequently have the potential to be easily measured biomarkers of neuroaxonal injury in various neurological conditions are discussed.
Abstract: Neuroaxonal damage is the pathological substrate of permanent disability in various neurological disorders. Reliable quantification and longitudinal follow-up of such damage are important for assessing disease activity, monitoring treatment responses, facilitating treatment development and determining prognosis. The neurofilament proteins have promise in this context because their levels rise upon neuroaxonal damage not only in the cerebrospinal fluid (CSF) but also in blood, and they indicate neuroaxonal injury independent of causal pathways. First-generation (immunoblot) and second-generation (enzyme-linked immunosorbent assay) neurofilament assays had limited sensitivity. Third-generation (electrochemiluminescence) and particularly fourth-generation (single-molecule array) assays enable the reliable measurement of neurofilaments throughout the range of concentrations found in blood samples. This technological advancement has paved the way to investigate neurofilaments in a range of neurological disorders. Here, we review what is known about the structure and function of neurofilaments, discuss analytical aspects and knowledge of age-dependent normal ranges of neurofilaments and provide a comprehensive overview of studies on neurofilament light chain as a marker of axonal injury in different neurological disorders, including multiple sclerosis, neurodegenerative dementia, stroke, traumatic brain injury, amyotrophic lateral sclerosis and Parkinson disease. We also consider work needed to explore the value of this axonal damage marker in managing neurological diseases in daily practice.
1,038 citations
TL;DR: It is demonstrated that the attenuation values of muscle on computed tomography in older persons can account for differences in muscle strength not attributed to muscle quantity.
Abstract: Although loss of muscle mass is considered a cause of diminished muscle strength with aging, little is known regarding whether composition of aging muscle affects strength. The skeletal muscle atte...
1,037 citations
University of Alberta1, Harvard University2, Johns Hopkins University3, University of Manitoba4, Mayo Clinic5, University of Pittsburgh6, University of Maryland, Baltimore7, University of California, San Diego8, Katholieke Universiteit Leuven9, Washington University in St. Louis10, National Institutes of Health11, Hannover Medical School12, University of Basel13, University of Sydney14, University of North Carolina at Chapel Hill15, John Radcliffe Hospital16, Saint Louis University17, Scripps Research Institute18, University of Barcelona19, Royal London Hospital20, University of Amsterdam21
TL;DR: The 8th Banff Conference on Allograft Pathology was held in Edmonton, Canada, 15–21 July 2005, and major outcomes included the elimination of the non‐specific term ‘chronic allograft nephropathy’ (CAN) and the recognition of the entity of chronic antibody‐mediated rejection.
1,036 citations
TL;DR: X-shooter as mentioned in this paper is the first 2nd generation instrument of the ESO Very Large Telescope (VLT), which was installed at the Cassegrain focus of UT2 in 2009.
Abstract: X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope(VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 to 2500 nm. It is designed to maximize the sensitivity in this spectral range through dichroic splitting in three arms with optimized optics, coatings, dispersive elements and detectors. It operates at intermediate spectral resolution (R~4,000 - 17,000, depending on wavelength and slit width) with fixed echelle spectral format (prism cross-dispersers) in the three arms. It includes a 1.8"x4" Integral Field Unit as an alternative to the 11" long slits. A dedicated data reduction package delivers fully calibrated two-dimensional and extracted spectra over the full wavelength range. We describe the main characteristics of the instrument and present its performance as measured during commissioning, science verification and the first months of science operations.
1,031 citations
Authors
Showing all 59759 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Richard A. Flavell | 231 | 1328 | 205119 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Kenneth C. Anderson | 178 | 1138 | 126072 |
| David A. Weitz | 178 | 1038 | 114182 |
| Dorret I. Boomsma | 176 | 1507 | 136353 |
| Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
| Michael Kramer | 167 | 1713 | 127224 |
| Nicholas J. White | 161 | 1352 | 104539 |
| Lex M. Bouter | 158 | 767 | 103034 |
| Wolfgang Wagner | 156 | 2342 | 123391 |
| Jerome I. Rotter | 156 | 1071 | 116296 |
| David Cella | 156 | 1258 | 106402 |
| David Eisenberg | 156 | 697 | 112460 |
| Naveed Sattar | 155 | 1326 | 116368 |