Institution
University of Amsterdam
Education•Amsterdam, Noord-Holland, Netherlands•
About: University of Amsterdam is a education organization based out in Amsterdam, Noord-Holland, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 59309 authors who have published 140894 publications receiving 5984137 citations. The organization is also known as: UvA & Universiteit van Amsterdam.
Papers published on a yearly basis
Papers
More filters
••
University of Iceland1, University of Manchester2, Charité3, University of California, San Diego4, Netherlands Bioinformatics Centre5, University of Amsterdam6, Chalmers University of Technology7, University of Virginia8, University of Sheffield9, Central Manchester University Hospitals NHS Foundation Trust10, University of Vienna11, University of North Texas12, California Institute of Technology13, European Bioinformatics Institute14, Babraham Institute15, University of Warwick16, University of Edinburgh17, Institute for Systems Biology18, University of Luxembourg19, Jacobs University Bremen20, Russian Academy of Sciences21, VU University Amsterdam22, Virginia Bioinformatics Institute23
TL;DR: Recon 2, a community-driven, consensus 'metabolic reconstruction', is described, which is the most comprehensive representation of human metabolism that is applicable to computational modeling and has improved topological and functional features.
Abstract: Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ~2× more reactions and ~1.7× more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type–specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.
1,002 citations
••
TL;DR: In this paper, the authors proposed a new normalized information distance based on the non-computable notion of Kolmogorov complexity, which minorizes every computable distance in the class (that is, it is universal in that it discovers all computable similarities).
Abstract: A new class of distances appropriate for measuring similarity relations between sequences, say one type of similarity per distance, is studied. We propose a new "normalized information distance," based on the noncomputable notion of Kolmogorov complexity, and show that it is in this class and it minorizes every computable distance in the class (that is, it is universal in that it discovers all computable similarities). We demonstrate that it is a metric and call it the similarity metric . This theory forms the foundation for a new practical tool. To evidence generality and robustness, we give two distinctive applications in widely divergent areas using standard compression programs like gzip and GenCompress. First, we compare whole mitochondrial genomes and infer their evolutionary history. This results in a first completely automatic computed whole mitochondrial phylogeny tree. Secondly, we fully automatically compute the language tree of 52 different languages.
1,002 citations
••
TL;DR: The hypothesis that simple choices indeed produce better results after conscious thought, but that choices in complex matters should be left to unconscious thought was confirmed in four studies on consumer choice.
Abstract: Contrary to conventional wisdom, it is not always advantageous to engage in thorough conscious deliberation before choosing. On the basis of recent insights into the characteristics of conscious and unconscious thought, we tested the hypothesis that simple choices (such as between different towels or different sets of oven mitts) indeed produce better results after conscious thought, but that choices in complex matters (such as between different houses or different cars) should be left to unconscious thought. Named the "deliberation-without-attention" hypothesis, it was confirmed in four studies on consumer choice, both in the laboratory as well as among actual shoppers, that purchases of complex products were viewed more favorably when decisions had been made in the absence of attentive deliberation.
997 citations
••
TL;DR: Pivotal for the clinical development of new sepsis therapies is the selection of patients on the basis of biomarkers and/or functional defects that provide specific insights into the expression or activity of the therapeutic target.
Abstract: Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. In sepsis, the immune response that is initiated by an invading pathogen fails to return to homeostasis, thus culminating in a pathological syndrome that is characterized by sustained excessive inflammation and immune suppression. Our understanding of the key mechanisms involved in the pathogenesis of sepsis has increased tremendously, yet this still needs to be translated into novel targeted therapeutic strategies. Pivotal for the clinical development of new sepsis therapies is the selection of patients on the basis of biomarkers and/or functional defects that provide specific insights into the expression or activity of the therapeutic target.
996 citations
••
TL;DR: In this paper, the authors demonstrate that emotional expressions affect observers' behavior by triggering inferential processes and/or affective reactions in them, and propose a new framework that can account for existing findings and guide future research.
Abstract: The idea that emotions regulate social interaction is increasingly popular. But exactly how do emotions do this? To address this question, I draw on research on the interpersonal effects of emotions on behavior in personal relationships, parent–child interactions, conflict, negotiation, and leadership, and propose a new framework that can account for existing findings and guide future research: the emotions as social information (EASI) model. I demonstrate that emotional expressions affect observers' behavior by triggering inferential processes and/or affective reactions in them. The predictive strength of these two processes—which may inspire different behaviors—depends on the observer's information processing and on social-relational factors. Examples of moderators that determine the relative predictive strength of inferences and affective reactions include power, need for cognitive closure, time pressure, display rules, and the appropriateness and target of the emotional expression, which are all discu...
995 citations
Authors
Showing all 59759 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard A. Flavell | 231 | 1328 | 205119 |
Scott M. Grundy | 187 | 841 | 231821 |
Stuart H. Orkin | 186 | 715 | 112182 |
Kenneth C. Anderson | 178 | 1138 | 126072 |
David A. Weitz | 178 | 1038 | 114182 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Michael Kramer | 167 | 1713 | 127224 |
Nicholas J. White | 161 | 1352 | 104539 |
Lex M. Bouter | 158 | 767 | 103034 |
Wolfgang Wagner | 156 | 2342 | 123391 |
Jerome I. Rotter | 156 | 1071 | 116296 |
David Cella | 156 | 1258 | 106402 |
David Eisenberg | 156 | 697 | 112460 |
Naveed Sattar | 155 | 1326 | 116368 |