Institution
University of Antwerp
Education•Antwerp, Belgium•
About: University of Antwerp is a education organization based out in Antwerp, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 16682 authors who have published 48837 publications receiving 1689748 citations. The organization is also known as: Universiteit Antwerpen & UAntwerp.
Papers published on a yearly basis
Papers
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TL;DR: The major finding is that business/IT alignment maturity is higher when organisations are applying a mix of mature IT governance practices.
Abstract: IT governance is one of these concepts that suddenly emerged and became an important issue in the information technology area. Many organisations started with the implementation of IT governance to achieve a better alignment between business and IT. This paper carries interpretations regarding important existing theories, models, and practices in the IT governance domain and presents research questions derived from it. Next, multiple research strategies are triangulated in order to explore how organisations are implementing IT governance and to analyse the relationship between these implementations and business/IT alignment. The major finding is that business/IT alignment maturity is higher when organisations are applying a mix of mature IT governance practices.
490 citations
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TL;DR: In this paper, the authors argue that coastal marsh vulnerability is often overstated because assessments generally neglect feedback processes known to accelerate soil building with sea level rise, as well as the potential for marshes to migrate inland.
Abstract: In this Perspective it is argued that coastal marsh vulnerability is often overstated because assessments generally neglect feedback processes known to accelerate soil building with sea level rise, as well as the potential for marshes to migrate inland. Coastal marshes are considered to be among the most valuable and vulnerable ecosystems on Earth, where the imminent loss of ecosystem services is a feared consequence of sea level rise. However, we show with a meta-analysis that global measurements of marsh elevation change indicate that marshes are generally building at rates similar to or exceeding historical sea level rise, and that process-based models predict survival under a wide range of future sea level scenarios. We argue that marsh vulnerability tends to be overstated because assessment methods often fail to consider biophysical feedback processes known to accelerate soil building with sea level rise, and the potential for marshes to migrate inland.
490 citations
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University of Helsinki1, University of Eastern Finland2, Finnish Meteorological Institute3, University of Antwerp4, Weizmann Institute of Science5, University of Bayreuth6, Seconda Università degli Studi di Napoli7, Woods Hole Research Center8, University of Kiel9, Max Planck Society10, Lund University11
TL;DR: In this article, the effect of soil moisture on chamber measurements was tested by wetting the fine quartz sand to about 25% volumetric water content, and the results showed that the chamber headspace concentration also affects the flux by altering the concentration gradient between the soil and the chamber.
489 citations
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TL;DR: The phenol extraction protocol was optimized for banana and was subsequently applied to two other plant species: apple and potato, and is useful for guiding the experimental setup of many other nonmodel species, containing various interfering elements.
Abstract: This study focuses on the specific problems of protein extraction from recalcitrant plant tissues and evaluates several methods to bypass them. Sample preparation is a critical step in a two-dimensional gel electrophoresis proteome approach and is absolutely essential for good results. We evaluated four methods: the classical trichloroacetic acid (TCA)/acetone precipitation, TCA/acetone precipitation and fractionation, an alternative based on fractionation and without precipitation, and phenol extraction methanol/ammonium acetate precipitation. We optimized the phenol extraction protocol for small amounts of tissue, which is essential when the study material is limited. The protocol was optimized for banana (Musa spp.) and was subsequently applied to two other plant species: apple (Malus domestica L.) and potato (Solanum tuberosum L.). Banana (Musa spp.) is a good representative of a "difficult" plant species since it contains many interfering metabolites. Only classical TCA/acetone precipitation and phenol extraction methods proved useful as standard methods. Both methods are associated with a minor but reproducible loss of proteins. Every extraction method and the subsequent analytical procedure have their physicochemical limitations; both methods should be investigated before selecting an appropriate protocol. The study, which is presented in this paper, is useful for guiding the experimental setup of many other nonmodel species, containing various interfering elements.
487 citations
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TL;DR: It became apparent that several of the five Parkinson genes were also contributing to the genetic etiology of other Lewy Body Diseases and Parkinson‐plus syndromes, indicating that mutation screening is recommendable in these patient groups.
Abstract: To date, molecular genetic analyses have identified over 500 distinct DNA variants in five disease genes associated with familial Parkinson disease; α-synuclein (SNCA), parkin (PARK2), PTEN-induced putative kinase 1 (PINK1), DJ-1 (PARK7), and Leucine-rich repeat kinase 2 (LRRK2). These genetic variants include ∼82% simple mutations and ∼18% copy number variations. Some mutation subtypes are likely underestimated because only few studies reported extensive mutation analyses of all five genes, by both exonic sequencing and dosage analyses. Here we present an update of all mutations published to date in the literature, systematically organized in a novel mutation database (http://www.molgen.ua.ac.be/PDmutDB). In addition, we address the biological relevance of putative pathogenic mutations. This review emphasizes the need for comprehensive genetic screening of Parkinson patients followed by an insightful study of the functional relevance of observed genetic variants. Moreover, while capturing existing data from the literature it became apparent that several of the five Parkinson genes were also contributing to the genetic etiology of other Lewy Body Diseases and Parkinson-plus syndromes, indicating that mutation screening is recommendable in these patient groups. Hum Mutat 31:763–780, 2010. © 2010 Wiley-Liss, Inc.
486 citations
Authors
Showing all 16957 results
Name | H-index | Papers | Citations |
---|---|---|---|
Cornelia M. van Duijn | 183 | 1030 | 146009 |
John Hardy | 177 | 1178 | 171694 |
Mark Gerstein | 168 | 751 | 149578 |
Hannes Jung | 159 | 2069 | 125069 |
Rui Zhang | 151 | 2625 | 107917 |
Dirk Inzé | 149 | 647 | 74468 |
Walter Paulus | 149 | 809 | 86252 |
Robin Erbacher | 138 | 1721 | 100252 |
Rupert Leitner | 136 | 1201 | 90597 |
Alison Goate | 136 | 721 | 85846 |
Andrea Giammanco | 135 | 1362 | 98093 |
Maria Spiropulu | 135 | 1455 | 96674 |
Peter Robmann | 135 | 1438 | 97569 |
Michael Tytgat | 134 | 1449 | 94133 |
Matthew Herndon | 133 | 1732 | 97466 |