Institution
University of Applied Sciences and Arts Northwestern Switzerland FHNW
Education•Windisch, Switzerland•
About: University of Applied Sciences and Arts Northwestern Switzerland FHNW is a education organization based out in Windisch, Switzerland. It is known for research contribution in the topics: Solar flare & Flare. The organization has 1072 authors who have published 1674 publications receiving 27907 citations. The organization is also known as: Fachhochschule Nordwestschweiz.
Topics: Solar flare, Flare, Chromosphere, Population, Context (language use)
Papers published on a yearly basis
Papers
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University of Helsinki1, Semmelweis University2, University of Szeged3, Hungarian Academy of Sciences4, University of Palermo5, Institute of Molecular Pathology and Immunology of the University of Porto6, University of Porto7, Autonomous University of Barcelona8, Instituto de Biologia Molecular e Celular9, Ikerbasque10, Harvard University11, University of Duisburg-Essen12, Paracelsus Private Medical University of Salzburg13, Salk Institute for Biological Studies14, University of Colorado Denver15, Bilkent University16, Middle East Technical University17, University of Southern Denmark18, Statens Serum Institut19, Ghent University Hospital20, Oslo University Hospital21, University of Belgrade22, University of Ljubljana23, University of Mainz24, Finnish Red Cross25, University of Gothenburg26, Latvian Biomedical Research and Study centre27, University of Applied Sciences and Arts Northwestern Switzerland FHNW28, University of Valencia29, Centro Nacional de Investigaciones Cardiovasculares30, University of Freiburg31, Utrecht University32, Trinity College, Dublin33, Catalan Institution for Research and Advanced Studies34, University of Barcelona35, International University Of Catalonia36, Aarhus University Hospital37
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Abstract: In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
3,690 citations
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University of California, Berkeley1, Queen Mary University of London2, Smithsonian Astrophysical Observatory3, University of Minnesota4, University of New Hampshire5, University of Maryland, College Park6, University of Orléans7, Imperial College London8, University of Colorado Boulder9, Goddard Space Flight Center10, University of Maryland, Baltimore County11, University of Iowa12, University of Michigan13, University of Applied Sciences and Arts Northwestern Switzerland FHNW14, University of Paris15, Princeton University16, Johns Hopkins University Applied Physics Laboratory17, University of California, Los Angeles18
TL;DR: Measurements from the Parker Solar Probe show that slow solar wind near the Sun’s equator originates in coronal holes, and plasma-wave measurements suggest the existence of electron and ion velocity-space micro-instabilities that are associated with plasma heating and thermalization processes.
Abstract: During the solar minimum, when the Sun is at its least active, the solar wind1,2 is observed at high latitudes as a predominantly fast (more than 500 kilometres per second), highly Alfvenic rarefied stream of plasma originating from deep within coronal holes. Closer to the ecliptic plane, the solar wind is interspersed with a more variable slow wind3 of less than 500 kilometres per second. The precise origins of the slow wind streams are less certain4; theories and observations suggest that they may originate at the tips of helmet streamers5,6, from interchange reconnection near coronal hole boundaries7,8, or within coronal holes with highly diverging magnetic fields9,10. The heating mechanism required to drive the solar wind is also unresolved, although candidate mechanisms include Alfven-wave turbulence11,12, heating by reconnection in nanoflares13, ion cyclotron wave heating14 and acceleration by thermal gradients1. At a distance of one astronomical unit, the wind is mixed and evolved, and therefore much of the diagnostic structure of these sources and processes has been lost. Here we present observations from the Parker Solar Probe15 at 36 to 54 solar radii that show evidence of slow Alfvenic solar wind emerging from a small equatorial coronal hole. The measured magnetic field exhibits patches of large, intermittent reversals that are associated with jets of plasma and enhanced Poynting flux and that are interspersed in a smoother and less turbulent flow with a near-radial magnetic field. Furthermore, plasma-wave measurements suggest the existence of electron and ion velocity-space micro-instabilities10,16 that are associated with plasma heating and thermalization processes. Our measurements suggest that there is an impulsive mechanism associated with solar-wind energization and that micro-instabilities play a part in heating, and we provide evidence that low-latitude coronal holes are a key source of the slow solar wind. Measurements from the Parker Solar Probe show that slow solar wind near the Sun’s equator originates in coronal holes.
391 citations
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Istituto Superiore di Sanità1, Trinity College, Dublin2, Autonomous University of Barcelona3, Semmelweis University4, University of Turin5, University of Palermo6, University of Porto7, University of Barcelona8, University of Oxford9, Karolinska Institutet10, Ghent University11, Bilkent University12, University of Ljubljana13, University of Nantes14, University of Belgrade15, University of Ioannina16, University of Applied Sciences and Arts Northwestern Switzerland FHNW17, University of Valencia18, ORT Braude College of Engineering19, Oslo University Hospital20, University of Freiburg21, National Research Council22, University of Zurich23, Centre national de la recherche scientifique24, Innsbruck Medical University25, University of Helsinki26, Autonomous University of Madrid27, University of Duisburg-Essen28
TL;DR: The high potential of nanosized EVs for both diagnostic and therapeutic areas of nanomedicine, as demonstrated by the European Network on Microvesicles and Exosomes in Health and Disease (ME-HAD), is demonstrated.
Abstract: Recent research has demonstrated that all body fluids assessed contain substantial amounts of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid membranes containing different membrane microdomains such as lipid rafts and caveolae. The most prominent representatives of these so-called extracellular vesicles (EVs) are nanosized exosomes (70-150 nm), which are derivatives of the endosomal system, and microvesicles (100-1000 nm), which are produced by outward budding of the plasma membrane. Nanosized EVs are released by almost all cell types and mediate targeted intercellular communication under physiological and pathophysiological conditions. Containing cell-type-specific signatures, EVs have been proposed as biomarkers in a variety of diseases. Furthermore, according to their physical functions, EVs of selected cell types have been used as therapeutic agents in immune therapy, vaccination trials, regenerative medicine, and drug delivery. Undoubtedly, the rapidly emerging field of basic and applied EV research will significantly influence the biomedicinal landscape in the future. In this Perspective, we, a network of European scientists from clinical, academic, and industry settings collaborating through the H2020 European Cooperation in Science and Technology (COST) program European Network on Microvesicles and Exosomes in Health and Disease (ME-HAD), demonstrate the high potential of nanosized EVs for both diagnostic and therapeutic (i.e., theranostic) areas of nanomedicine.
371 citations
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TL;DR: The findings imply that turnover includes opportunities to optimize one’s circumstances and that CSE helps to attain resourceful jobs.
Abstract: Core self-evaluations (CSE) might account for relative gains in job resources across time, especially in situations when these individual differences affect behavior that is relevant for development of job resources. This longitudinal study tests CSE as an individual resource that predicts relative gain in job resources and job satisfaction among job beginners who change or stay with their employer. A questionnaire was filled in by 513 adolescents shortly before the end of vocational training and one year later. Our results replicate previous findings suggesting that job satisfaction is affected by CSE directly and indirectly through the perception of job resources. Multi-group structural equation analysis showed that only leavers had a longitudinal indirect effect of CSE on job satisfaction at the end of vocational training via job resources during their first year of employment. Our findings imply that turnover includes opportunities to optimize one’s circumstances and that CSE helps to attain resourceful jobs.
351 citations
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TL;DR: The recent development of analytical techniques and methods enables accurate selenium measurements of environmental concentrations, which will lead to a better understanding of biogeochemical processes, which may enable us to predict the distribution of Se health hazards in areas where this is currently unknown.
Abstract: Selenium is a natural trace element that is of fundamental importance to human health. The extreme geographical variation in selenium concentrations in soils and food crops has resulted in significant health problems related to deficient or excess levels of selenium in the environment. To deal with these kinds of problems in the future it is essential to get a better understanding of the processes that control the global distribution of selenium. The recent development of analytical techniques and methods enables accurate selenium measurements of environmental concentrations, which will lead to a better understanding of biogeochemical processes. This improved understanding may enable us to predict the distribution of selenium in areas where this is currently unknown. These predictions are essential to prevent future Se health hazards in a world that is increasingly affected by human activities.
334 citations
Authors
Showing all 1121 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ernest Weingartner | 82 | 245 | 22996 |
Arnold O. Benz | 73 | 367 | 19269 |
Charlotte Braun-Fahrländer | 69 | 185 | 16085 |
Säm Krucker | 65 | 372 | 18539 |
Karl Fent | 49 | 135 | 9564 |
Jörg Huwyler | 46 | 216 | 8592 |
Willi Meier | 38 | 149 | 7883 |
Veronika Butterweck | 37 | 120 | 4217 |
Anthony Arundel | 37 | 126 | 6243 |
Thomas Wintgens | 37 | 114 | 6562 |
Lucia Kleint | 37 | 115 | 5902 |
Tanja Manser | 36 | 146 | 5068 |
Alexander Repenning | 35 | 140 | 3874 |
Jens Gobrecht | 35 | 112 | 4219 |
Philippe F.-X. Corvini | 35 | 119 | 3155 |