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Showing papers by "University of Arizona published in 1994"


Journal ArticleDOI
29 Jul 1994-Science
TL;DR: In this paper, large ensembles of hippocampal "place cells" were recorded from three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors, showing an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.
Abstract: Simultaneous recordings were made from large ensembles of hippocampal "place cells" in three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors. Cells that fired together when the animal occupied particular locations in the environment exhibited an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks. Cells that were inactive during behavior, or that were active but had non-overlapping spatial firing, did not show this increase. This effect, which declined gradually during each post-behavior sleep session, may result from synaptic modification during waking experience. Information acquired during active behavior is thus re-expressed in hippocampal circuits during sleep, as postulated by some theories of memory consolidation.

2,655 citations


Journal ArticleDOI
TL;DR: In this article, a modified SAVI (MSAVI) was proposed to increase the dynamic range of the vegetation signal while further minimizing the soil background influences, resulting in greater vegetation sensitivity as defined by a vegetation signal to soil noise ratio.

2,309 citations


Journal ArticleDOI
TL;DR: In this article, the spectral energy distributions (SEDs) of normal, nonblazar, quasars over the whole available range (radio to 10 keV X-rays) of the electromagnetic spectrum are presented.
Abstract: We present an atlas of the spectral energy distributions (SEDs) of normal, nonblazar, quasars over the whole available range (radio to 10 keV X-rays) of the electromagnetic spectrum. The primary (UVSX) sample includes 47 quasars for which the spectral energy distributions include X-ray spectral indices and UV data. Of these, 29 are radio quiet, and 18 are radio loud. The SEDs are presented both in figures and in tabular form, with additional tabular material published on CD-ROM. Previously unpublished observational data for a second set of quasars excluded from the primary sample are also tabulated. The effects of host galaxy starlight contamination and foreground extinction on the UVSX sample are considered and the sample is used to investigate the range of SED properties. Of course, the properties we derive are influenced strongly by the selection effects induced by quasar discovery techniques. We derive the mean energy distribution (MED) for radio-loud and radio-quiet objects and present the bolometric corrections derived from it. We note, however, that the dispersion about this mean is large (approximately one decade for both the infrared and ultraviolet components when the MED is normalized at the near-infrared inflection). At least part of the dispersion in the ultraviolet may be due to time variability, but this is unlikely to be important in the infrared. The existence of such a large dispersion indicates that the MED reflects only some of the properties of quasars and so should be used only with caution.

1,923 citations


Journal ArticleDOI
TL;DR: This paper found that if the right to be the first mover is "earned" by scoring high on a general knowledge quiz, then first movers behave in a more self-regarding manner.

1,708 citations


Journal ArticleDOI
TL;DR: In this paper, the authors examined four alternative methods for estimating the extent of labor market discrimination. All of the methods involve the decomposition of gross (unadjusted) wage differentials into discrimination and productivity components.

1,640 citations


Proceedings ArticleDOI
01 Oct 1994
TL;DR: This paper motivates and describes the three key techniques employed by Vegas, and presents the results of a comprehensive experimental performance study—using both simulations and measurements on the Internet— of the Vegas and Reno implementations of TCP.
Abstract: Vegas is a new implementation of TCP that achieves between 40 and 70% better throughput, with one-fifth to one-half the losses, as compared to the implementation of TCP in the Reno distribution of BSD Unix. This paper motivates and describes the three key techniques employed by Vegas, and presents the results of a comprehensive experimental performance study—using both simulations and measurements on the Internet—of the Vegas and Reno implementations of TCP.

1,399 citations


Journal ArticleDOI
TL;DR: In this paper, the authors investigated the relationship between the characteristic oxygen abundance, the radial abundance gradient, and the macroscopic properties of spiral galaxies by examining the properties of individual H II regions within those galaxies.
Abstract: We investigate the relationships between the characteristic oxygen abundance, the radial abundance gradient, and the macroscopic properties of spiral galaxies by examining the properties of individual H II regions within those galaxies Our observations of the line flux ratio (O II) lambda lambda 3726, 3729 + (O III) lambda lambda 4959, 5007)/H beta for 159 H II regions in 14 spiral galaxies are combined with published data to provide a sample of 39 disk galaxies for which (O II) + (O III)/H beta has been measured for at least five H II regions We find that the characteristic gas-phase abundances and luminosities of spiral galaxies are strongly correlated This relationship maps almost directly onto the luminosity-metallicity relationship of irregular galaxies and is also quite similar to that found for elliptical and dwarf spheroidal galaxies Within our sample of spirals, a strong correlation between characteristic abundance and Hubble type also exists The correlation between luminosity and Hubble type complicates the issue, but we discuss several interpretations of the correlations The relationship between circular velocity and characteristic abundance is also discussed We find that the slopes of the radial abundance gradients, when expressed in units of dex/isophotal radius, do not significantly correlate with either luminosity or Hubble type However, the hypothesis that both early and very late type spirals have shallower gradients than intermediate spirals is consistent with the data We find suggestive evidence that the presence of a bar induces a flatter gradient and also briefly discuss whether abundance gradients are exponential, as is usually assumed We investigate the properties of individual H II regions in a subset of 42 regions for which we have spectra that cover almost the entire spectral range from 3500 to 9800 A We use those data to estimate the densitites and ionizing spectra within the H II regions We confirm that the ionizing spectrum hardens with increasing radius and decreasing abundance We find no correlation between the ionization parameter and either radius or abundance, but this may be due to significant scatter introduced by the simple conversion of line ratios to ionization parameter

1,392 citations


Journal ArticleDOI
TL;DR: In this paper, the scaling laws of fully developed turbulence are described in terms of scalings of a sequence of moment ratios of the energy dissipation field at inertial-range scale l. These moment ratios form a hierarchy of structures.
Abstract: The inertial-range scaling laws of fully developed turbulence are described in terms of scalings of a sequence of moment ratios of the energy dissipation field ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{l}}$ coarse-grained at inertial-range scale l. These moment ratios ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{l}}^{(\mathit{p})}$=〈${\mathrm{\ensuremath{\epsilon}}}_{\mathit{l}}^{\mathit{p}+1}$〉/〈${\mathrm{\ensuremath{\epsilon}}}_{\mathit{l}}^{\mathit{p}}$〉(p=0, 1, 2,...,) form a hierarchy of structures. The most singular structures ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{l}}^{(\mathrm{\ensuremath{\infty}})}$ are assumed to be filaments, and it is argued that ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{l}}^{(\mathrm{\ensuremath{\infty}})}$\ensuremath{\sim}${\mathit{l}}^{\mathrm{\ensuremath{-}}2/3}$. Furthermore, a universal relation between scalings of successive structures is postulated, which leads to a prediction of the entire set of the scaling exponents: 〈${\mathrm{\ensuremath{\epsilon}}}_{\mathit{l}}^{\mathit{p}}$〉\ensuremath{\sim}${\mathit{l}}_{\mathit{p}}^{\mathrm{\ensuremath{\tau}}}$, ${\mathrm{\ensuremath{\tau}}}_{\mathit{p}}$=-2/3p+2[1-( 2) / 3 ${)}^{\mathit{p}}$] and 〈\ensuremath{\delta}${\mathit{v}}_{\mathit{l}}^{\mathit{p}}$〉\ensuremath{\sim}${\mathit{l}}_{\mathit{p}}^{\mathrm{\ensuremath{\zeta}}}$, ${\mathrm{\ensuremath{\zeta}}}_{\mathit{p}}$=p/9+2[1-(2/3${)}^{\mathit{p}/3}$].

1,217 citations


Journal ArticleDOI
TL;DR: The essential concepts of the SCE-UA method are reviewed and the results of several experimental studies in which the National Weather Service river forecast system-soil moisture accounting model was calibrated using different algorithmic parameter setups are presented.

1,212 citations


Journal ArticleDOI
TL;DR: It is postulate that this residual AR activity may be sufficient for development of male primary and secondary sex characteristics, but may fall below a threshold level of activity necessary for normal maintenance of motor neuron function.
Abstract: Some transcription factors contain stretches of polyglutamine encoded by repeats of the trinucleotide CAG. Expansion of the CAG repeat in the androgen receptor (AR) has been correlated with the incidence and severity of X-linked spinal and bulbar muscular atrophy (Kennedy's disease). In order to understand the relationship of this mutation to AR function, we constructed ARs that varied in the position and size of the polyglutamine tract, and assayed for the abilities of these mutant receptors to bind androgen and to activate transcription of several different AR-responsive reporter genes. Elimination of the tract in both human and rat AR resulted in elevated transcriptional activation activity, strongly suggesting that the presence of the polyglutamine tract is inhibitory to transactivation. Progressive expansion of the CAG repeat in human AR caused a linear decrease of transactivation function. Importantly, expansion of the tract did not completely eliminate AR activity. We postulate that this residual AR activity may be sufficient for development of male primary and secondary sex characteristics, but may fall below a threshold level of activity necessary for normal maintenance of motor neuron function. This functional abnormality may be representative of other genetic diseases that are associated with CAG expansion mutations in open reading frames, such as spinocerebellar ataxia type I and Huntington's disease.

1,137 citations


Journal ArticleDOI
TL;DR: The KDQOLTM was administered to 165 individuals with kidney disease, sampled from nine different outpatient dialysis centres located in Southern California, the Northwest, and the Midwest, and provided support for the reliability and validity of the measure.
Abstract: This paper describes the Kidney Disease Quality of Life (KDQOLTM) Instrument (dialysis version), a self-report measure that includes a 36-item health survey as the generic core, supplemented with multi-item scales targeted at particular concerns of individuals with kidney disease and on dialysis (symptom/problems, effects of kidney disease on daily life, burden of kidney disease, cognitive function, work status, sexual function, quality of social interaction, sleep). Also included were multi-item measures of social support, dialysis staff encouragement and patient satisfaction, and a single-item overall rating of health. The KDQOLTM was administered to 165 individuals with kidney disease (52% female; 48% male; 47% White; 27% African-American; 11% Hispanic; 8% Asian; 4% Native American; and 3% other ethnicities), sampled from nine different outpatient dialysis centres located in Southern California, the Northwest, and the Midwest. The average age of the sample was 53 years (range from 22 to 87), and 10% were 75 years or older. Internal consistency reliability estimates for the 19 multi-item scales exceeded 0.75 for every measure except one. The mean scores for individuals in this sample on the 36-item health scales were lower than the general population by one-quarter (emotional well-being) to a full standard deviation (physical function, role limitations due to physical health, general health), but similar to scores for dialysis patients in other studies. Correlations of the KDQOLTM scales with number of hospital days in the last 6 months were statistically significant (p<0.05) for 14 of the 19 scales and number of medications currently being taken for nine of the scales. Results of this study provide support for the reliability and validity of the KDQOLTM.

Journal ArticleDOI
TL;DR: In this article, the authors show how ethnography can provide multiple strategically important perspectives on behaviors of interest to marketing researchers, and they discuss the goals and four essential characte-...
Abstract: The authors show how ethnography can provide multiple strategically important perspectives on behaviors of interest to marketing researchers. They first discuss the goals and four essential charact...

Journal ArticleDOI
TL;DR: Dairy cattle in areas with relatively moderate climates also are exposed to periods of heat stress, and the resultant decrease in milk production and reproductive efficiency can be offset by implementation of a program consisting of cooling through shades, ventilation and spray, and fans.

Journal ArticleDOI
TL;DR: Interspecific interactions are traditionally displayed in a grid in which each interaction is placed according to its outcome, but the full range of natural outcomes may reveal far more about its ecological and evolutionary dynamics than does the average outcome at a given place and time.
Abstract: Interspecific interactions are traditionally displayed in a grid in which each interaction is placed according to its outcome (positive, negative or neutral) for each partner. However, recent field studies consistently find the costs and benefits that determine net effects to vary greatly in both space and time, inevitably causing outcomes within most interactions to vary as well. Interactions show ‘conditionality' when costs and benefits, and thus outcomes, are affected in predictable ways by current ecological conditions. The full range of natural outcomes of a given association may reveal far more about its ecological and evolutionary dynamics than does the average outcome at a given place and time.

Journal ArticleDOI
TL;DR: Fishman and Clevedon as discussed by the authors proposed the Reversing Language Shift: Theoretical and Empirical Foundations of Assistance to Threatened Languages, which is the foundation of our work.
Abstract: Reversing Language Shift: Theoretical and Empirical Foundations of Assistance to Threatened Languages. Joshua A. Fishman. Multilingual Matters, 76. Clevedon: Multilingual Matters, 1991. 431 pp.

Journal ArticleDOI
TL;DR: Findings suggest that mortality salience effects are unique to thoughts of death and occur primarily when such thoughts are highly accessible but outside of consciousness.
Abstract: On the basis of terror management theory, research has shown that subtle mortality salience inductions engender increased prejudice, nationalism, and intergroup bias. Study 1 replicated this effect (increased preference for a pro-U.S. author over an anti-U.S. author) and found weaker effects when Ss are led to think more deeply about mortality or about the death of a loved one. Study 2 showed that this effect is not produced by thoughts of non-death-related aversive events. Studies 2 and 3 demonstrated that this effect occurs only if Ss are distracted from mortality salience before assessment of its effects. Study 4 revealed that although the accessibility of death-related thoughts does not increase immediately after mortality salience, it does increase after Ss are distracted from mortality salience. These findings suggest that mortality salience effects are unique to thoughts of death and occur primarily when such thoughts are highly accessible but outside of consciousness. Language: en

Proceedings Article
Udi Manber1
17 Jan 1994
TL;DR: Application of sif can be found in file management, information collecting, program reuse, file synchronization, data compression, and maybe even plagiarism detection.
Abstract: We present a tool, called sif, for finding all similar files in a large file system. Files are considered similar if they have significant number of common pieces, even if they are very different otherwise. For example, one file may be contained, possibly with some changes, in another file, or a file may be a reorganization of another file. The running time for finding all groups of similar files, even for as little as 25% similarity, is on the order of 500MB to 1GB an hour. The amount of similarity and several other customized parameters can be determined by the user at a post-processing stage, which is very fast. Sif can also be used to very quickly identify all similar files to a query file using a preprocessed index. Application of sif can be found in file management, information collecting (to remove duplicates), program reuse, file synchronization, data compression, and maybe even plagiarism detection.

Journal ArticleDOI
TL;DR: It is concluded that the checkpoint in budding yeast consists of overlapping S-phase and G2-phase pathways that respond to incomplete DNA replication and/or DNA damage and cause arret of cells before mitosis.
Abstract: In eukaryotes a cell-cycle control termed a checkpoint causes arrest in the S or G2 phases when chromosomes are incompletely replicated or damaged. Previously, we showed in budding yeast that RAD9 and RAD17 are checkpoint genes required for arrest in the G2 phase after DNA damage. Here, we describe a genetic strategy that identified four additional checkpoint genes that act in two pathways. Both classes of genes are required for arrest in the G2 phase after DNA damage, and one class of genes is also required for arrest in S phase when DNA replication is incomplete. The Gz-specific genes include MEC3 (for mitosis entry checkpoint), RAD9, RAD17, and RAD24. The genes common to both S phase and G2 phase pathways are MECl and MEC2. The MEC2 gene proves to be identical to the RAD53 gene. Checkpoint mutants were identified by their interactions with a temperature-sensitive allele of the cell division cycle gene CDC13-, cdcl3 mutants arrested in G2 and survived at the restrictive temperature, whereas all cdcl3 checkpoint double mutants failed to arrest in G2 and died rapidly at the restrictive temperature. The cell-cycle roles of the RAD and MEC genes were examined by combination of rad and mec mutant alleles with 10 cdc mutant alleles that arrest in different stages of the cell cycle at the restrictive temperature and by the response of rad and mec mutant alleles to DNA damaging agents and to hydroxyurea, a drug that inhibits DNA replication. We conclude that the checkpoint in budding yeast consists of overlapping S-phase and G2-phase pathways that respond to incomplete DNA replication and/or DNA damage and cause arrest of cells before mitosis.

Journal ArticleDOI
TL;DR: A septotemporal difference of spatial selectivity was found in the CA1 field of the rat hippocampus, complementing many other anatomical and neuropharmacological studies and possible functional interpretations can be suggested.
Abstract: The septal and temporal poles of the hippocampus differ markedly in their anatomical and neurochemical organization. Although it is well established that the internal representation of space is a fundamental function of hippocampal neurons, most of what is known about spatial coding in the hippocampus of freely moving animals has come from recordings from the dorsal one-third (largely for technical convenience). The present study therefore compared the spatial selectivity of CA1 neurons in the dorsal and ventral hippocampi of rats during performance of a food reinforced, random search task in a square chamber containing simple visual landmarks. Neural activity was recorded in the dorsal and ventral hippocampi of opposite hemispheres in the same rats, in many cases simultaneously. As in dorsal hippocampus, ventral CA1 units could be classified as "complex spike" (pyramidal) cells or "theta" interneurons. Both dorsal and ventral theta cells fired at relatively high rates and with low spatial selectivity in the apparatus. Of the population of complex spike cells in the ventral hippocampus, a significantly smaller number had "place fields" than in the dorsal hippocampus, and the average spatial selectivity was of significantly lower resolution than that found among dorsal hippocampal complex spike cells. Thus, a septotemporal difference of spatial selectivity was found in the CA1 field of the rat hippocampus, complementing many other anatomical and neuropharmacological studies. A number of possible functional interpretations can be suggested from these results, including a computational advantage of representing space at different scales or a preeminence of essentially nonspatial information processing in the ventral hippocampus.

Journal ArticleDOI
TL;DR: In this article, the authors present experimental evidence extending the investigation of free-riding behavior in public goods provision and present procedures to deal with the logistical problems inherent in experiments involving many subjects.

Journal Article
TL;DR: Kinetic analysis demonstrates that wortmannin is a noncompetitive, irreversible inhibitor of phosphatidylinositol-3-kinase, with inactivation being both time- and concentration-dependent.
Abstract: Phosphatidylinositol-3-kinase is an important enzyme for intracellular signaling. The microbial product wortmannin and some of its analogues have been shown to be potent inhibitors of phosphatidylinositol-3-kinase. The 50% inhibitory concentration for inhibition by wortmannin is 2 to 4 nM. Kinetic analysis demonstrates that wortmannin is a noncompetitive, irreversible inhibitor of phosphatidylinositol-3-kinase, with inactivation being both time- and concentration-dependent. Wortmannin has previously been reported to be an inhibitor of myosin light chain kinase but with an inhibitory concentration of 0.2 microM. Wortmannin was found not to be an inhibitor of phosphatidylinositol-4-kinase, protein kinase C, or protein tyrosine kinase. Wortmannin inhibited the formation of phosphatidylinositol-3-phosphates in intact cells. The results of the study suggest that wortmannin and its analogues may have utility as pharmacological probes for studying the actions of phosphatidylinositol-3-kinase.

Journal ArticleDOI
TL;DR: In this paper, the limiting behavior of systems of hyperbolic conservation laws with stiff relaxation terms was studied and the convergence to the reduced dynamics for the 2 × 2 case was studied.
Abstract: We study the limiting behavior of systems of hyperbolic conservation laws with stiff relaxation terms. Reduced systems, inviscid and viscous local conservation laws, and weakly nonlinear limits are derived through asymptotic expansions. An entropy condition is introduced for N × N systems that ensures the hyperbolicity of the reduced inviscid system. The resulting characteristic speeds are shown to be interlaced with those of the original system. Moreover, the first correction to the reduced system is shown to be dissipative. A partial converse is proved for 2 × 2 systems. This structure is then applied to study the convergence to the reduced dynamics for the 2 × 2 case. © 1994 John Wiley & Sons, Inc.

Journal ArticleDOI
01 Oct 1994-Nature
TL;DR: In this article, the authors describe a polymer composite with excellent photorefractive properties, achieving a diffraction efficiency approaching 100% and a net two-beam coupling gain of more than 200 cm-1.
Abstract: PHOTOREFRACTIVE materials are of considerable interest for the development of all-optical devices1. The photoref ractive effect appears in materials that exhibit an electric-field-dependent refractive index and that are photosensitive, such that the spatial distribution of photogenerated charge carriers is modified on irradiation with light. The diffraction pattern formed by the interference of two coherent light beams within such a material generates a non-uniform internal electric field that in turn modulates the refractive index. The resulting refractive-index pattern forms a grating that can diffract light and thereby give rise to two-beam coupling, whereby one of the writing beams gains energy at the expense of the other—a property that can be exploited in photonic devices. Although the best photorefractive materials currently available are inorganic crystals such as LiNbO3, there is considerable interest in the development of photorefractive polymers2–8, owing to their structural flexibility, ease of processing and lower cost. We describe here a polymer composite with excellent photorefractive properties. We have achieved a diffraction efficiency approaching 100% and a net two-beam coupling gain of more than 200 cm–1, making these polymeric materials suitable for immediate application in areas such as dynamic holographic storage and optical information processing1.

Journal ArticleDOI
TL;DR: It is suggested that BCL-2 either directly or indirectly regulates the flux of Ca2+ across the ER membrane, thereby abrogating Ca2- signaling of apoptosis.
Abstract: BCL-2 is a 26-kDa integral membrane protein that represses apoptosis by an unknown mechanism. Recent findings indicate that Ca2+ release from the endoplasmic reticulum (ER) mediates apoptosis in mouse lymphoma cells. In view of growing evidence that BCL-2 localizes to the ER, as well as mitochondria and the perinuclear membrane, we investigated the possibility that BCL-2 represses apoptosis by regulating Ca2+ fluxes through the ER membrane. A cDNA encoding BCL-2 was introduced into WEHI7.2 cells and two subclones, W.Hb12 and W.Hb13, which express high and low levels of BCL-2 mRNA and protein, respectively, were isolated. WEHI7.2 cells underwent apoptosis in response to treatment with the glucocorticoid hormone dexamethasone, whereas W.Hb12 and W.Hb13 cells were protected from apoptosis, revealing a direct relationship between the level of BCL-2 expression and the degree of protection. Significantly, BCL-2 also blocked induction of apoptosis by thapsigargin (TG), a highly specific inhibitor of the ER-associated Ca2+ pump. TG completely inhibited ER Ca2+ pumping in both WEHI7.2 and W.Hb12 cells, but the release of Ca2+ into the cytosol after inhibition of ER Ca2+ pumping was significantly less in W.Hb12 cells than in WEHI7.2 cells, indicating that BCL-2 reduces Ca2+ efflux through the ER membrane. By reducing ER Ca2+ efflux, BCL-2 interfered with a signal for "capacitative" entry of extracellular Ca2+, preventing a sustained increase of cytosolic Ca2+ in TG-treated cells. These findings suggest that BCL-2 either directly or indirectly regulates the flux of Ca2+ across the ER membrane, thereby abrogating Ca2+ signaling of apoptosis.

Journal ArticleDOI
TL;DR: The authors argued that democratic states are better equipped than others with the means for diffusing conflict situations at an early stage before they have an opportunity to escalate to military violence, based on universal democratic norms for reconciling competing values and interests.
Abstract: The research reported here develops an explanation for the often-noted absence of international war between democratic states. This explanation is derived from a theoretical rationale centered on universal democratic norms for reconciling competing values and interests. I argue that democratic states locked in disputes are better equipped than others with the means for diffusing conflict situations at an early stage before they have an opportunity to escalate to military violence. Not only is this explanatory logic consistent with the published findings on democracy and war, but it also entails the novel empirical proposition that disputes between democracies are more amenable than are other disputes to peaceful settlements, the hypothesis I examine here. Analyses of contemporary interstate disputes reveal that even when potentially confounding factors are controlled, democratic opponents are significantly more likely to reach peaceful settlements than other types of disputants.

Journal ArticleDOI
TL;DR: In this article, the authors present an extensive study of the inception of supernova explosions by following the evolution of the cores of two massive stars (15 and 25 Solar mass) in multidimension.
Abstract: We present an extensive study of the inception of supernova explosions by following the evolution of the cores of two massive stars (15 and 25 Solar mass) in multidimension. Our calculations begin at the onset of core collapse and stop several hundred milliseconds after the bounce, at which time successful explosions of the appropriate magnitude have been obtained. Similar to the classical delayed explosion mechanism of Wilson, the explosion is powered by the heating of the envelope due to neutrinos emitted by the protoneutron star as it radiates the gravitational energy liberated by the collapse. However, as was shown by Herant, Benz, & Colgate, this heating generates strong convection outside the neutrinosphere, which we demonstrate to be critical to the explosion. By breaking a purely stratified hydrostatic equilibrium, convection moves the nascent supernova away from a delicate radiative equilibrium between neutrino emission and absorption, Thus, unlike what has been observed in one-dimensional calculations, explosions are rendered quite insensitive to the details of the physical input parameters such as neutrino cross sections or nuclear equation of state parameters. As a confirmation, our comparative one-dimensional calculations with identical microphysics, but in which convection cannot occur, lead to dramatic failures. Guided by our numerical results, we have developed a paradigm for the supernova explosion mechanism. We view a supernova as an open cycle thermodynamic engine in which a reservoir of low-entropy matter (the envelope) is thermally coupled and physically connected to a hot bath (the protoneutron star) by a neutrino flux, and by hydrodynamic instabilities. This paradigm does not invoke new or modified physics over previous treatments, but relies on compellingly straightforward thermodynamic arguments. It provides a robust and self-regulated explosion mechanism to power supernovae that is effective under a wide range of physical parameters.

Journal ArticleDOI
TL;DR: There may be a simple association between movement and head-directionality that serves to transform the egocentric movement representation in the neocortex into an allocentric directional representations in the periallocortex.
Abstract: We examined the behavioral modulation of head-directional information processing in neurons of the rat posterior cortices, including the medial prestriate (area Oc2M) and retrosplenial cortex (areas RSA and RSG). Single neurons were recorded in freely moving rats which were trained to perform a spatial working memory task on a radial-arm maze in a cue-controlled room. A dual-light-emitting diode (dual-LED) recording headstage, mounted on the animals' heads, was used to track head position and orientation. Planar modes of motion, such as turns, straight motion, and nonlocomotive states, were categorized using an objective scheme based upon the differential contributions of movement parameters, including linear and angular velocity of the head. Of 662 neurons recorded from the posterior cortices, 41 head-direction (HD) cells were identified based on the criterion of maintained directional bias in the absence of visual cues or in the dark. HD cells constituted 7 of 257 (2.7%) cells recorded in Oc2M, 26 of 311 (8.4%) cells in RSA, and 8 of 94 (8.5%) cells in RSG. Spatial tuning of HD cell firing was modulated by the animal's behaviors in some neurons. The behavioral modulation occurred either at the preferred direction or at all directions. Moreover, the behavioral selectivity was more robust for turns than straight motions, suggesting that the angular movements may significantly contribute to the head-directional processing. These behaviorally selective HD cells were observed most frequently in Oc2M (4/7, 57%), as only 5 of 26 (19%) of RSA cells and none of the RSG cells showed behavioral modulation. These data, taken together with the anatomical evidence for a cascade of projections from Oc2M to RSA and thence to RSG, suggest that there may be a simple association between movement and head-directionality that serves to transform the egocentric movement representation in the neocortex into an allocentric directional representation in the periallocortex.

Journal ArticleDOI
TL;DR: A mRNA decay pathway in which deadenylation leads to decapping of the mRNA followed by 5'-->3' exonucleolytic degradation of the transcript body is defined, which is a general mechanism for the decay of many eukaryotic transcripts.
Abstract: The first step in the decay of some eukaryotic mRNAs is the shortening of the poly(A) tail. To examine how the transcript body was degraded after deadenylation, we followed the decay of a pulse of newly synthesized MFA2 transcripts while utilizing two strategies to trap intermediates in the degradation pathway. First, we inserted strong RNA secondary structures, which can slow exonucleolytic digestion and thereby trap decay intermediates, into the MFA2 5' UTR. Following deadenylation, fragments of the MFA2 mRNA trimmed from the 5' end to the site of secondary structure accumulated as full-length mRNA levels decreased. In addition, in cells deleted for the XRN1 gene, which encodes a major 5' to 3' exonuclease in yeast, the MFA2 transcript is deadenylated normally but persists as a full-length mRNA lacking the 5' cap structure. These results define a mRNA decay pathway in which deadenylation leads to decapping of the mRNA followed by 5'-->3' exonucleolytic degradation of the transcript body. Because the poly(A) tail and the cap structure are found on essentially all mRNAs, this pathway could be a general mechanism for the decay of many eukaryotic transcripts.

Journal ArticleDOI
TL;DR: The recently identified “B” biotype, characterised by a diagnostic esterase banding pattern and by its ability to induce phytotoxic responses in squash, honeysuckle and nightshade was readily distinguished from non-’B’ biotype populations.
Abstract: Summary Eighteen populations of Bemisia tabaci, collected from different geographic locations (North & Central America, the Caribbean, Africa, the Middle East, Asia and Europe), were studied to identify and compare biological and genetic characteristics that can be used to differentiate biotypes. The morphology of the fourth instar/pupal stage and compound eye structures of adults were investigated using scanning electron microscopy and found to be typical of the species among all biotypes and populations studied. Setae and spines of B. tabaci larval scales from the same colony were highly variable depending on the host plant species or leaf surface characteristics. The location and the morphology of caudal setae, characteristic of all B. tabaci studied to date, were present in all colonies. However, differences in adult body lengths and in the ability to induce phy to toxic disorders in certain plant species were found between biotypes or populations. The recently identified “B” biotype, characterised by a diagnostic esterase banding pattern and by its ability to induce phytotoxic responses in squash, honeysuckle and nightshade was readily distinguished from non-“B” biotype populations. None of the non-“B” biotypes studied, were found to induce phytotoxic responses. Nine populations examined showed typical “B” biotype characteristics, regardless of country of origin. All tested populations, determined as “B” or “B”-like biotypes successfully mated with other “B” biotype colonies from different geographic areas. Non-“B” biotype colonies did not interbreed with other biotypes. The B. tabaci populations were tested for their ability to transmit 15 whitefly-transmitted geminiviruses (WTGs) from different geographic areas with a wide range of symptom types. All WTGs were transmitted by the “B” biotype colonies and by most non-“B” biotype colonies, with the exception of three viruses found in ornamental plants which were non-transmissible by any colony. Some non-“B” biotypes would not transmit certain geminiviruses and some geminiviruses were more efficiently transmitted than were others.

Journal ArticleDOI
TL;DR: A theory of the value of children based on the uncertainty-reduction assumption is proposed and a range of hypotheses that follow both from this assumption and from a subsidiary assumption of marital solidarity enhancement are generated.
Abstract: This paper uses a non-standard value assumption--uncertainty reduction--to explain parenthood. We begin by reviewing the inadequacies of normative and standard rational choice explanations of shifts in fertility behavior. Then we propose a theory of the value of children based on the uncertainty-reduction assumption. Next we generate a range of hypotheses that follow both from this assumption and from a subsidiary assumption of marital solidarity enhancement. Finally, we explore the extent to which implications based on these new ideas are supported by the relevant empirical literature.