University of Arizona

About: University of Arizona is a education organization based out in Tucson, Arizona, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 63805 authors who have published 155998 publications receiving 6854915 citations. The organization is also known as: UA & U of A.

Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

Abstract: Since eukaryotic cells constantly encounter various environmental insults, they have evolved defense mechanisms to cope with toxicant- and carcinogen-induced oxidative stress or electrophiles. One of the most important cellular defense mechanisms against oxidative stress or electrophiles is mediated by the transcription factor Nrf2. Under the basal condition, Nrf2-dependent transcription is repressed by a negative regulator Keap1. When cells are exposed to oxidative stress, electrophiles, or chemopreventive agents, Nrf2 escapes Keap1-mediated repression and activates antioxidant responsive element (ARE)-dependent gene expression to maintain cellular redox homeostasis. Beyond its antioxidant function, Nrf2 has recently been recognized as a key factor regulating an array of genes that defend cells against the deleterious effects of environmental insults. Since this Nrf2-dependent cellular defense response is able to protect multi-organs or multi-tissues, activation of Nrf2 has been implicated in conferring ...

Insect P450 enzymes.

Abstract: The P450 enzymes (mixed function oxidases, cytochrome P450 monooxygenases), a diverse class of enzymes found in virtually all insect tissues, fulfill many important tasks, from the synthesis and degradation of ecdysteroids and juvenile hormones to the metabolism of foreign chemicals of natural or synthetic origin. This diversity in function is achieved by a diversity in structure, as insect genomes probably carry about 100 P450 genes, sometimes arranged in clusters, and each coding for a different P450 enzyme. Both microsomal and mitochondrial P450s are present in insects and are best studied by heterologous expression of their cDNA and reconstitution of purified enzymes. P450 genes are under complex regulation, with induction playing a central role in the adaptation to plant chemicals and regulatory mutations playing a central role in insecticide resistance. Polymorphisms in induction or constitutive expression allow insects to scan their P450 gene repertoire for the appropriate response to chemical insults, and these evolutionary pressures in turn maintain P450 diversity.

Formulation and comparison of two recursive matrix algorithms for modeling layered diffraction gratings

Abstract: Two recursive and numerically stable matrix algorithms for modeling layered diffraction gratings, the S-matrix algorithm and the R-matrix algorithm, are systematically presented in a form that is independent of the underlying grating models, geometries, and mountings. Many implementation variants of the algorithms are also presented. Their physical interpretations are given, and their numerical stabilities and efficiencies are discussed in detail. The single most important criterion for achieving unconditional numerical stability with both algorithms is to avoid the exponentially growing functions in every step of the matrix recursion. From the viewpoint of numerical efficiency, the S-matrix algorithm is generally preferred to the R-matrix algorithm, but exceptional cases are noted.

Thermosensory activation of insular cortex.

Abstract: Temperature sensation is regarded as a submodality of touch, but evidence suggests involvement of insular cortex rather than parietal somatosensory cortices. Using positron emission tomography (PET), we found contralateral activity correlated with graded cooling stimuli only in the dorsal margin of the middle/posterior insula in humans. This corresponds to the thermoreceptive- and nociceptive-specific lamina I spinothalamocortical pathway in monkeys, and can be considered an enteroceptive area within limbic sensory cortex. Because lesions at this site can produce the post-stroke central pain syndrome, this finding supports the proposal that central pain results from loss of the normal inhibition of pain by cold. Notably, perceived thermal intensity was well correlated with activation in the right (ipsilateral) anterior insular and orbitofrontal cortices.

Sentiment analysis in multiple languages: Feature selection for opinion classification in Web forums

Abstract: The Internet is frequently used as a medium for exchange of information and opinions, as well as propaganda dissemination. In this study the use of sentiment analysis methodologies is proposed for classification of Web forum opinions in multiple languages. The utility of stylistic and syntactic features is evaluated for sentiment classification of English and Arabic content. Specific feature extraction components are integrated to account for the linguistic characteristics of Arabic. The entropy weighted genetic algorithm (EWGA) is also developed, which is a hybridized genetic algorithm that incorporates the information-gain heuristic for feature selection. EWGA is designed to improve performance and get a better assessment of key features. The proposed features and techniques are evaluated on a benchmark movie review dataset and U.S. and Middle Eastern Web forum postings. The experimental results using EWGA with SVM indicate high performance levels, with accuracies of over 91p on the benchmark dataset as well as the U.S. and Middle Eastern forums. Stylistic features significantly enhanced performance across all testbeds while EWGA also outperformed other feature selection methods, indicating the utility of these features and techniques for document-level classification of sentiments.