Institution
University of Arizona
Education•Tucson, Arizona, United States•
About: University of Arizona is a education organization based out in Tucson, Arizona, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 63805 authors who have published 155998 publications receiving 6854915 citations. The organization is also known as: UA & U of A.
Topics: Population, Galaxy, Star formation, Redshift, Planet
Papers published on a yearly basis
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University of California, San Diego1, University of Arizona2, Ghent University3, Université libre de Bruxelles4, University of Erlangen-Nuremberg5, California Institute of Technology6, University of Sheffield7, Spanish National Research Council8, University of Basel9, University of British Columbia10, University of California, San Francisco11, Anschutz Medical Campus12, Karolinska University Hospital13, Pompeu Fabra University14, University of South Australia15, Memorial Sloan Kettering Cancer Center16, National Taiwan University17, Hebrew University of Jerusalem18, University of Texas MD Anderson Cancer Center19, Princeton University20, Northeastern University21, Washington University in St. Louis22, University College London23, Duke University24, Royal Children's Hospital25, Claude Bernard University Lyon 126, PSL Research University27, Université Paris-Saclay28, University of Pennsylvania29, Kyoto University30, University of Toulouse31, Queensland University of Technology32, Massachusetts Institute of Technology33, University of Pittsburgh34, University of Kentucky35, Kumamoto University36
TL;DR: This Consensus Statement is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications to reduce misunderstanding and misinterpretation of research data generated in various experimental models.
Abstract: Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.
931 citations
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TL;DR: Transcript regulation in response to high salinity was investigated for salt-tolerant rice with microarrays including 1728 cDNAs from libraries of salt-stressed roots and the interpretation of an adaptive process was supported by the similar analysis of salinity-sensitive rice.
Abstract: Transcript regulation in response to high salinity was investigated for salt-tolerant rice (var Pokkali) with microarrays including 1728 cDNAs from libraries of salt-stressed roots. NaCl at 150 mM reduced photosynthesis to one tenth of the prestress value within minutes. Hybridizations of RNA to microarray slides probed for changes in transcripts from 15 min to 1 week after salt shock. Beginning 15 min after the shock, Pokkali showed upregulation of transcripts. Approximately 10% of the transcripts in Pokkali were significantly upregulated or downregulated within 1 hr of salt stress. The initial differences between control and stressed plants continued for hours but became less pronounced as the plants adapted over time. The interpretation of an adaptive process was supported by the similar analysis of salinity-sensitive rice (var IR29), in which the immediate response exhibited by Pokkali was delayed and later resulted in downregulation of transcription and death. The upregulated functions observed with Pokkali at different time points during stress adaptation changed over time. Increased protein synthesis and protein turnover were observed at early time points, followed by the induction of known stress-responsive transcripts within hours, and the induction of transcripts for defenserelated functions later. After 1 week, the nature of upregulated transcripts (e.g., aquaporins) indicated recovery.
931 citations
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TL;DR: Results suggest that the soil at the Phoenix landing site must have suffered alteration through the action of liquid water in geologically the recent past, and revealed an alkaline environment in contrast to that found by the Mars Exploration Rovers, indicating that many different environments have existed on Mars.
Abstract: The Wet Chemistry Laboratory on the Phoenix Mars Lander performed aqueous chemical analyses of martian soil from the polygon-patterned northern plains of the Vastitas Borealis. The solutions contained ~10 mM of dissolved salts with 0.4 to 0.6% perchlorate (ClO 4 ) by mass leached from each sample. The remaining anions included small concentrations of chloride, bicarbonate, and possibly sulfate. Cations were dominated by Mg 2+ and Na + , with small contributions from K + and Ca 2+ . A moderately alkaline pH of 7.7 ± 0.5 was measured, consistent with a carbonate-buffered solution. Samples analyzed from the surface and the excavated boundary of the ~5-centimeter-deep ice table showed no significant difference in soluble chemistry.
929 citations
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TL;DR: DWI tractography shows that the IFC and the STN region are connected via a white matter tract, which could underlie a “hyperdirect” pathway for basal ganglia control and demonstrates a three-way functional–anatomical network in the right hemisphere that could either brake or completely stop responses.
Abstract: The ability to stop motor responses depends critically on the right inferior frontal cortex (IFC) and also engages a midbrain region consistent with the subthalamic nucleus (STN). Here we used diffusion-weighted imaging (DWI) tractography to show that the IFC and the STN region are connected via a white matter tract, which could underlie a “hyperdirect” pathway for basal ganglia control. Using a novel method of “triangulation” analysis of tractography data, we also found that both the IFC and the STN region are connected with the presupplementary motor area (preSMA). We hypothesized that the preSMA could play a conflict detection/resolution role within a network between the preSMA, the IFC, and the STN region. A second experiment tested this idea with functional magnetic resonance imaging (fMRI) using a conditional stop-signal paradigm, enabling examination of behavioral and neural signatures of conflict-induced slowing. The preSMA, IFC, and STN region were significantly activated the greater the conflict-induced slowing. Activation corresponded strongly with spatial foci predicted by the DWI tract analysis, as well as with foci activated by complete response inhibition. The results illustrate how tractography can reveal connections that are verifiable with fMRI. The results also demonstrate a three-way functional–anatomical network in the right hemisphere that could either brake or completely stop responses.
929 citations
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TL;DR: Children learn the meanings of smaller number words before larger ones within their counting range, up to the number three or four, indicating that children learn the cardinal word principle at roughly 3 1/2 years of age.
926 citations
Authors
Showing all 64388 results
Name | H-index | Papers | Citations |
---|---|---|---|
Simon D. M. White | 189 | 795 | 231645 |
Julie E. Buring | 186 | 950 | 132967 |
David H. Weinberg | 183 | 700 | 171424 |
Richard Peto | 183 | 683 | 231434 |
Xiaohui Fan | 183 | 878 | 168522 |
Dennis S. Charney | 179 | 802 | 122408 |
Daniel J. Eisenstein | 179 | 672 | 151720 |
David Haussler | 172 | 488 | 224960 |
Carlos S. Frenk | 165 | 799 | 140345 |
Jian-Kang Zhu | 161 | 550 | 105551 |
Tobin J. Marks | 159 | 1621 | 111604 |
Todd Adams | 154 | 1866 | 143110 |
Jane A. Cauley | 151 | 914 | 99933 |
Wei Zheng | 151 | 1929 | 120209 |
Daniel L. Schacter | 149 | 592 | 90148 |