University of Arizona

About: University of Arizona is a education organization based out in Tucson, Arizona, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 63805 authors who have published 155998 publications receiving 6854915 citations. The organization is also known as: UA & U of A.

Matching words and pictures

Abstract: We present a new approach for modeling multi-modal data sets, focusing on the specific case of segmented images with associated text. Learning the joint distribution of image regions and words has many applications. We consider in detail predicting words associated with whole images (auto-annotation) and corresponding to particular image regions (region naming). Auto-annotation might help organize and access large collections of images. Region naming is a model of object recognition as a process of translating image regions to words, much as one might translate from one language to another. Learning the relationships between image regions and semantic correlates (words) is an interesting example of multi-modal data mining, particularly because it is typically hard to apply data mining techniques to collections of images. We develop a number of models for the joint distribution of image regions and words, including several which explicitly learn the correspondence between regions and words. We study multi-modal and correspondence extensions to Hofmann's hierarchical clustering/aspect model, a translation model adapted from statistical machine translation (Brown et al.), and a multi-modal extension to mixture of latent Dirichlet allocation (MoM-LDA). All models are assessed using a large collection of annotated images of real scenes. We study in depth the difficult problem of measuring performance. For the annotation task, we look at prediction performance on held out data. We present three alternative measures, oriented toward different types of task. Measuring the performance of correspondence methods is harder, because one must determine whether a word has been placed on the right region of an image. We can use annotation performance as a proxy measure, but accurate measurement requires hand labeled data, and thus must occur on a smaller scale. We show results using both an annotation proxy, and manually labeled data.

Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity

Abstract: Biological reactivity to psychological stressors comprises a complex, integrated, and highly conserved repertoire of central neural and peripheral neuroendocrine responses designed to prepare the organism for challenge or threat. Developmental experience plays a role, along with heritable, polygenic variation, in calibrating the response dynamics of these systems, with early adversity biasing their combined effects toward a profile of heightened or prolonged reactivity. Conventional views of such high reactivity suggest that it is an atavistic and pathogenic legacy of an evolutionary past in which threats to survival were more prevalent and severe. Recent evidence, however, indicates that (a) stress reactivity is not a unitary process, but rather incorporates counterregulatory circuits serving to modify or temper physiological arousal, and (b) the effects of high reactivity phenotypes on psychiatric and biomedical outcomes are bivalent, rather than univalent, in character, exerting both risk-augmenting and risk-protective effects in a context-dependent manner. These observations suggest that heightened stress reactivity may reflect, not simply exaggerated arousal under challenge, but rather an increased biological sensitivity to context, with potential for negative health effects under conditions of adversity and positive effects under conditions of support and protection. From an evolutionary perspective, the developmental plasticity of the stress response systems, along with their structured, context-dependent effects, suggests that these systems may constitute conditional adaptations: evolved psychobiological mechanisms that monitor specific features of childhood environments as a basis for calibrating the development of stress response systems to adaptively match those environments. Taken together, these theoretical perspectives generate a novel hypothesis: that there is a curvilinear, U-shaped relation between early exposures to adversity and the development of stress-reactive profiles, with high reactivity phenotypes disproportionately emerging within both highly stressful and highly protected early social environments.

Global-scale temperature patterns and climate forcing over the past six centuries

Abstract: Spatially resolved global reconstructions of annual surface temperature patterns over the past six centuries are based on the multivariate calibration of widely distributed high-resolution proxy climate indicators. Time-dependent correlations of the reconstructions with time-series records representing changes in greenhouse-gas concentrations, solar irradiance, and volcanic aerosols suggest that each of these factors has contributed to the climate variability of the past 400 years, with greenhouse gases emerging as the dominant forcing during the twentieth century. Northern Hemisphere mean annual temperatures for three of the past eight years are warmer than any other year since (at least) ad 1400.

Human gut microbiota in obesity and after gastric bypass

Abstract: Recent evidence suggests that the microbial community in the human intestine may play an important role in the pathogenesis of obesity. We examined 184,094 sequences of microbial 16S rRNA genes from PCR amplicons by using the 454 pyrosequencing technology to compare the microbial community structures of 9 individuals, 3 in each of the categories of normal weight, morbidly obese, and post-gastric-bypass surgery. Phylogenetic analysis demonstrated that although the Bacteria in the human intestinal community were highly diverse, they fell mainly into 6 bacterial divisions that had distinct differences in the 3 study groups. Specifically, Firmicutes were dominant in normal-weight and obese individuals but significantly decreased in post-gastric-bypass individuals, who had a proportional increase of Gammaproteobacteria. Numbers of the H2-producing Prevotellaceae were highly enriched in the obese individuals. Unlike the highly diverse Bacteria, the Archaea comprised mainly members of the order Methanobacteriales, which are H2-oxidizing methanogens. Using real-time PCR, we detected significantly higher numbers of H2-utilizing methanogenic Archaea in obese individuals than in normal-weight or post-gastric-bypass individuals. The coexistence of H2-producing bacteria with relatively high numbers of H2-utilizing methanogenic Archaea in the gastrointestinal tract of obese individuals leads to the hypothesis that interspecies H2 transfer between bacterial and archaeal species is an important mechanism for increasing energy uptake by the human large intestine in obese persons. The large bacterial population shift seen in the post-gastric-bypass individuals may reflect the double impact of the gut alteration caused by the surgical procedure and the consequent changes in food ingestion and digestion.

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Abstract: DOMINANT alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide1–6. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone receptor (MC1-R)7, thus explaining the inhibitory effect of agouti on eumelanin pigment synthesis. The agouti peptide is also an antagonist of the hypothalamic melanocortin-4 receptor (MC4-R)7–9. To test the hypothesis that agouti causes obesity by antagonism of hypothalamic melanocortin receptors7, we identified cyclic melanocortin analogues10 that are potent agonists or antagonists of the neural MC3 (refs 11, 12) and MC4 receptors. Intracerebroventricular administration of the agonist, MTII, inhibited feeding in four models of hyperphagia: fasted C57BL/6J, ob/ob, and AY mice, and mice injected with neuropeptide Y. Co-administration of the specific melanocortin antagonist and agouti-mimetic SHU9119 completely blocked this inhibition. Furthermore, administration of SHU9119 significantly enhanced nocturnal feeding, or feeding stimulated by a prior fast. Our data show that melanocortinergic neurons exert a tonic inhibition of feeding behaviour. Chronic disruption of this inhibitory signal is a likely explanation of the agouti obesity syndrome.