Institution
University of Bamako
Education•Bamako, Mali•
About: University of Bamako is a education organization based out in Bamako, Mali. It is known for research contribution in the topics: Malaria & Plasmodium falciparum. The organization has 486 authors who have published 575 publications receiving 25418 citations. The organization is also known as: University of Mali.
Papers published on a yearly basis
Papers
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University of Maryland, College Park1, Max Planck Society2, University of California, Los Angeles3, University of Ferrara4, University of Pennsylvania5, University of Bamako6, University of Khartoum7, Stellenbosch University8, Muhimbili University of Health and Allied Sciences9, Dartmouth College10, Kenya Medical Research Institute11, National Institutes of Health12, Marshfield Clinic13, Vanderbilt University14
TL;DR: A detailed genetic analysis of most major groups of African populations is provided, suggesting that Africans represent 14 ancestral populations that correlate with self-described ethnicity and shared cultural and/or linguistic properties.
Abstract: Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (approximately 71%), European (approximately 13%), and other African (approximately 8%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies.
1,376 citations
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University of Barcelona1, University of Melbourne2, University of Valle3, University of Ghana4, University of Notre Dame5, University of Bamako6, University of London7, National Institutes of Health8, University of Maryland, Baltimore9, World Health Organization10, Imperial College London11, Centers for Disease Control and Prevention12, Swiss Tropical and Public Health Institute13
TL;DR: The Malaria Eradication Research Agenda initiative and the set of articles published in this PLoS Medicine Supplement that distill the research questions key to malaria eradication are introduced.
Abstract: The interruption of malaria transmission worldwide is one of the greatest challenges for international health and development communities. The current expert view suggests that, by aggressively scaling up control with currently available tools and strategies, much greater gains could be achieved against malaria, including elimination from a number of countries and regions; however, even with maximal effort we will fall short of global eradication. The Malaria Eradication Research Agenda (malERA) complements the current research agenda—primarily directed towards reducing morbidity and mortality—with one that aims to identify key knowledge gaps and define the strategies and tools that will result in reducing the basic reproduction rate to less than 1, with the ultimate aim of eradication of the parasite from the human population. Sustained commitment from local communities, civil society, policy leaders, and the scientific community, together with a massive effort to build a strong base of researchers from the endemic areas will be critical factors in the success of this new agenda.
646 citations
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TL;DR: The reintroduction ofchloroquine, ideally in combination with another antimalarial drug, should be considered in areas where chloroquine resistance has declined and safe and affordable alternatives remain unavailable.
Abstract: In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum malaria. To determine whether withdrawal of chloroquine can lead to the reemergence of chloroquine sensitivity, the prevalence of the pfcrt 76T molecular marker for chloroquine-resistant Plasmodium falciparum malaria was retrospectively measured in Blantyre, Malawi. The prevalence of the chloroquine-resistant pfcrt genotype decreased from 85% in 1992 to 13% in 2000. In 2001, chloroquine cleared 100% of 63 asymptomatic P. falciparum infections, no isolates were resistant to chloroquine in vitro, and no infections with the chloroquine-resistant pfcrt genotype were detected. A concerted national effort to withdraw chloroquine from use has been followed by a return of chloroquine-sensitive falciparum malaria in Malawi. The reintroduction of chloroquine, ideally in combination with another antimalarial drug, should be considered in areas where chloroquine resistance has declined and safe and affordable alternatives remain unavailable.
530 citations
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TL;DR: Two new species within the Anopheles gambiae complex are here described and named, based on molecular and bionomical evidence.
Abstract: Two new species within the Anopheles gambiae complex are here described and named. Based on molecular and bionomical evidence, the An. gambiae molecular "M form" is named Anopheles coluzzii Coetzee & Wilkerson sp. n., while the "S form" retains the nominotypical name Anopheles gambiae Giles. Anopheles quadriannulatus is retained for the southern African populations of this species, while the Ethiopian species is named Anopheles amharicus Hunt, Wilkerson & Coetzee sp. n., based on chromosomal, cross-mating and molecular evidence.
470 citations
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Mahidol University1, University of California, San Francisco2, University of Cape Town3, University of Tübingen4, Wellcome Trust5, University of Western Australia6, University of Oxford7, University of Paris8, World Health Organization9, University of Bamako10, Swiss Tropical and Public Health Institute11, University of Lausanne12, Pasteur Institute13, Novartis14, Liverpool School of Tropical Medicine15, Karolinska Institutet16, Walter and Eliza Hall Institute of Medical Research17, Drugs for Neglected Diseases Initiative18, University of Southern Denmark19, Mahosot Hospital20, National University of Laos21, International Military Sports Council22, Muhimbili University of Health and Allied Sciences23, Yale University24, Uppsala University25, University of Washington26, University of Amsterdam27
TL;DR: Higher, more frequent, or prolonged dosage regimens should now be evaluated in very young children, particularly if malnourished, and in patients with hyperparasitemia, as well as patients in very low transmission intensity areas with emerging parasite resistance.
Abstract: Background: Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with artemether-lumefantrine efficacy. However, the 'therapeutic' day 7 lumefantrine concentration threshold needs to be defined better, particularly for important patient and parasite sub-populations. Methods: The WorldWide Antimalarial Resistance Network (WWARN) conducted a large pooled analysis of individual pharmacokinetic-pharmacodynamic data from patients treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria, to define therapeutic day 7 lumefantrine concentrations and identify patient factors that substantially alter these concentrations. A systematic review of PubMed, Embase, Google Scholar, ClinicalTrials.gov and conference proceedings identified all relevant studies. Risk of bias in individual studies was evaluated based on study design, methodology and missing data. Results: Of 31 studies identified through a systematic review, 26 studies were shared with WWARN and 21 studies with 2,787 patients were included. Recrudescence was associated with low day 7 lumefantrine concentrations (HR 1.59 (95 % CI 1.36 to 1.85) per halving of day 7 concentrations) and high baseline parasitemia (HR 1.87 (95 % CI 1.22 to 2.87) per 10-fold increase). Adjusted for mg/kg dose, day 7 concentrations were lowest in very young children (98 % cure rates (if parasitemia <135,000/μL). Conclusions: Current artemether-lumefantrine dosing recommendations achieve day 7 lumefantrine concentrations ≥200 ng/ml and high cure rates in most uncomplicated malaria patients. Three groups are at increased risk of treatment failure: very young children (particularly those underweight-for-age); patients with high parasitemias; and patients in very low transmission intensity areas with emerging parasite resistance. In these groups, adherence and treatment response should be monitored closely. Higher, more frequent, or prolonged dosage regimens should now be evaluated in very young children, particularly if malnourished, and in patients with hyperparasitemia.
445 citations
Authors
Showing all 494 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ogobara K. Doumbo | 72 | 345 | 22666 |
Scott Montgomery | 64 | 375 | 15345 |
Teun Bousema | 64 | 283 | 12935 |
Tovi Lehmann | 55 | 132 | 7699 |
Davidson H. Hamer | 54 | 341 | 11193 |
Alister Craig | 45 | 152 | 12884 |
Drissa Diallo | 43 | 133 | 4481 |
Sekou F. Traore | 41 | 133 | 4725 |
Mahamadou A. Thera | 38 | 90 | 5540 |
Issaka Sagara | 38 | 88 | 3451 |
Abdoulaye Djimde | 38 | 149 | 4423 |
Alassane Dicko | 38 | 110 | 4494 |
Yeya T. Touré | 36 | 67 | 4494 |
Donald J. Krogstad | 35 | 108 | 5079 |
Dapa A. Diallo | 33 | 97 | 4225 |