University of Basel

About: University of Basel is a education organization based out in Basel, Basel-Stadt, Switzerland. It is known for research contribution in the topics: Population & Transplantation. The organization has 25084 authors who have published 52975 publications receiving 2388002 citations. The organization is also known as: Universität Basel & Basel University.

Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial

Abstract: Eosinophilic oesophagitis (EoO) is a clinicopathological condition defined by proton pump inhibitor-refractory oesophageal symptoms combined with oesophageal eosinophilia. The pharmacodynamic effect of mepolizumab (a humanised anti-interleukin-5 monoclonal antibody) in EoO was evaluated.

Protoneutron star evolution and the neutrino-driven wind in general relativistic neutrino radiation hydrodynamics simulations

Abstract: Massive stars end their lives in explosions with kinetic energies on the order of 10 51 erg. Immediately after the explosion has been launched, a region of low density and high entropy forms behind the ejecta, which is continuously subject to neutrino heating. The neutrinos emitted from the remnant at the center, the protoneutron star (PNS), heat the material above the PNS surface. This heat is partly converted into kinetic energy, and the material accelerates to an outflow that is known as the neutrino-driven wind. For the first time we simulate the collapse, bounce, explosion, and the neutrino-driven wind phases consistently over more than 20 s. Our numerical model is based on spherically symmetric general relativistic radiation hydrodynamics using spectral three-flavor Boltzmann neutrino transport. In simulations where no explosions are obtained naturally, we model neutrino-driven explosions for low- and intermediatemass Fe-core progenitor stars by enhancing the charged current reaction rates. In the case of a special progenitor star, the 8. 8M � O-Ne-Mg-core, the explosion in spherical symmetry was obtained without enhanced opacities. The post-explosion evolution is in qualitative agreement with static steady-state and parametrized dynamic models of the neutrino-driven wind. On the other hand, we generally find lower neutrino luminosities and mean neutrino energies, as well as a different evolutionary behavior of the neutrino luminosities and mean neutrino energies. The neutrino-driven wind is proton-rich for more than 10 s and the contraction of the PNS differs from the assumptions made for the conditions at the inner boundary in previous neutrino-driven wind studies. Despite the moderately high entropies of about 100 kB/baryon and the fast expansion timescales, the conditions found in our models are unlikely to favor r-process nucleosynthesis. The simulations are carried out until the neutrino-driven wind settles down to a quasi-stationary state. About 5 s after the bounce, the peak temperature inside the PNS already starts to decrease because of the continued deleptonization. This moment determines the beginning of a cooling phase dominated by the emission of neutrinos. We discuss the physical conditions of the quasi-static PNS evolution and take the effects of deleptonization and mass accretion from early fallback into account.

Electrical control of a long-lived spin qubit in a Si/SiGe quantum dot.

Abstract: The electron spin in a silicon-based quantum dot can be controlled electrically for as long as several tens of microseconds, which improves the prospects for quantum information processing based on this type of quantum dot. Nanofabricated quantum bits permit large-scale integration but usually suffer from short coherence times due to interactions with their solid-state environment1. The outstanding challenge is to engineer the environment so that it minimally affects the qubit, but still allows qubit control and scalability. Here, we demonstrate a long-lived single-electron spin qubit in a Si/SiGe quantum dot with all-electrical two-axis control. The spin is driven by resonant microwave electric fields in a transverse magnetic field gradient from a local micromagnet2, and the spin state is read out in the single-shot mode3. Electron spin resonance occurs at two closely spaced frequencies, which we attribute to two valley states. Thanks to the weak hyperfine coupling in silicon, a Ramsey decay timescale of 1 μs is observed, almost two orders of magnitude longer than the intrinsic timescales in GaAs quantum dots4,5, whereas gate operation times are comparable to those reported in GaAs6,7,8. The spin echo decay time is ∼40 μs, both with one and four echo pulses, possibly limited by intervalley scattering. These advances strongly improve the prospects for quantum information processing based on quantum dots.

Pax-6 in development and evolution

Abstract: Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosophila melanogaster, and Caenorhabditis elegans suggest that Pax-6 homologues share conserved functions. In this review, we present recent data on the structural and functional characterization of Pax-6 homologues from species of different animal phyla. We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems.

Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation

Abstract: Mast cells have a central role in allergic diseases mediated by specific immunoglobulin E antibody responses to allergens. The binding of IgE to the high-affinity receptor for IgE (Fc epsilon R) on mast cells and basophils enables these cells to react specifically to allergens. Such contact leads to the activation of mast cells and the release of histamine and other pharmacological mediators, causing an immediate hypersensitivity and acute inflammatory reactions, accompanied by the development of allergic symptoms. Here we show that Fc epsilon R-mediated activation of murine mast cells results in the production of the haemopoietic growth factors granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3). IL-3 and GM-CSF, in addition to their role in bone marrow haemopoiesis, also influence inflammation as they have the capacity to recruit, prime and activate inflammatory cells such as neutrophils, macrophages and eosinophils. Secretion of these factors by mast cells in response to allergens may therefore have an important role in local tissue defense.