Institution
University of Basel
Education•Basel, Basel-Stadt, Switzerland•
About: University of Basel is a education organization based out in Basel, Basel-Stadt, Switzerland. It is known for research contribution in the topics: Population & Transplantation. The organization has 25084 authors who have published 52975 publications receiving 2388002 citations. The organization is also known as: Universität Basel & Basel University.
Topics: Population, Transplantation, Gene, Poison control, Quantum dot
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McMaster University1, Norwegian Institute of Public Health2, University of Florida3, Bond University4, University at Buffalo5, Autonomous University of Barcelona6, United States Department of Veterans Affairs7, University of Basel8, Mayo Clinic9, Harvard University10, University of Freiburg11, Agency for Healthcare Research and Quality12, Oregon Health & Science University13, Case Western Reserve University14
TL;DR: Systematic review authors and guideline developers may also consider rating up quality of evidence when a dose-response gradient is present, and when all plausible confounders or biases would decrease an apparent treatment effect, or would create a spurious effect when results suggest no effect.
873 citations
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TL;DR: The present catalog of 2096 galaxies within an area of about 140 sq deg approximately centered on the Virgo cluster should be an essentially complete listing of all certain and possible cluster members, independent of morphological type as discussed by the authors.
Abstract: The present catalog of 2096 galaxies within an area of about 140 sq deg approximately centered on the Virgo cluster should be an essentially complete listing of all certain and possible cluster members, independent of morphological type. Cluster membership is essentially decided by galaxy morphology; for giants and the rare class of high surface brightness dwarfs, membership rests on velocity data. While 1277 of the catalog entries are considered members of the Virgo cluster, 574 are possible members and 245 appear to be background Zwicky galaxies. Major-to-minor axis ratios are given for all galaxies brighter than B(T) = 18, as well as for many fainter ones.
872 citations
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World Health Organization1, University of North Carolina at Chapel Hill2, Emory University3, University of California, Berkeley4, University of London5, Aberystwyth University6, University of East Anglia7, Swiss Federal Institute of Aquatic Science and Technology8, University of Basel9, Swiss Tropical and Public Health Institute10
TL;DR: The burden of diarrhoeal diseases from exposure to inadequate water, sanitation and hand hygiene in low‐ and middle‐income settings and an overview of the impact on other diseases are estimated.
Abstract: objective To estimate the burden of diarrhoeal diseases from exposure to inadequate water, sanitation and hand hygiene in low- and middle-income settings and provide an overview of the impact on other diseases. methods For estimating the impact of water, sanitation and hygiene on diarrhoea, we selected exposure levels with both sufficient global exposure data and a matching exposure-risk relationship. Global exposure data were estimated for the year 2012, and risk estimates were taken from the most recent systematic analyses. We estimated attributable deaths and disability-adjusted life years (DALYs) by country, age and sex for inadequate water, sanitation and hand hygiene separately, and as a cluster of risk factors. Uncertainty estimates were computed on the basis of uncertainty surrounding exposure estimates and relative risks. results In 2012, 502 000 diarrhoea deaths were estimated to be caused by inadequate drinking water and 280 000 deaths by inadequate sanitation. The most likely estimate of disease burden from inadequate hand hygiene amounts to 297 000 deaths. In total, 842 000 diarrhoea deaths are estimated to be caused by this cluster of risk factors, which amounts to 1.5% of the total disease burden and 58% of diarrhoeal diseases. In children under 5 years old, 361 000 deaths could be prevented, representing 5.5% of deaths in that age group. conclusions This estimate confirms the importance of improving water and sanitation in low- and middle-income settings for the prevention of diarrhoeal disease burden. It also underscores the need for better data on exposure and risk reductions that can be achieved with provision of reliable piped water, community sewage with treatment and hand hygiene.
869 citations
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TL;DR: In this article, the evolution of all stable nuclei and their radioactive progeni- tors in stellar models computed from the onset of central hydrogen burning through explosion as Type II supernovae was studied.
Abstract: We present the first calculations to follow the evolution of all stable nuclei and their radioactive progeni- tors in stellar models computed from the onset of central hydrogen burning through explosion as Type II supernovae. Calculations are performed for Population I stars of 15, 19, 20, 21, and 25 Musing the most recently available experimental and theoretical nuclear data, revised opacity tables, neutrino losses, and weak interaction rates and taking into account mass loss due to stellar winds. A novel '' adaptive '' reaction net- work is employed with a variable number of nuclei (adjusted each time step) ranging from � 700 on the main sequence to e2200 during the explosion. The network includes, at any given time, all relevant isotopes from hydrogen through polonium (Z ¼ 84). Even the limited grid of stellar masses studied suggests that overall good agreement can be achieved with the solar abundances of nuclei between 16 O and 90 Zr. Interesting dis- crepancies are seen in the 20 Mmodel and (so far, only in that model) are a consequence of the merging of the oxygen, neon, and carbon shells about a day prior to core collapse. We find that, in some stars, most of the '' p-process '' nuclei can be produced in the convective oxygen-burning shell moments prior to collapse; in others, they are made only in the explosion. Serious deficiencies still exist in all cases for the p-process isotopes of Ru and Mo. Subject headings: nuclear reactions, nucleosynthesis, abundances — stars: evolution — supernovae: general On-line material: machine-readable tables
867 citations
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Christian Fuchsberger1, Christian Fuchsberger2, Jason Flannick3, Jason Flannick4 +346 more•Institutions (77)
TL;DR: In this paper, the authors performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing for 12,940 individuals from five ancestry groups.
Abstract: The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups. To increase statistical power, we expanded the sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes.
866 citations
Authors
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Name | H-index | Papers | Citations |
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Yang Yang | 171 | 2644 | 153049 |
Martin Karplus | 163 | 831 | 138492 |
Frank J. Gonzalez | 160 | 1144 | 96971 |
Paul Emery | 158 | 1314 | 121293 |
Matthias Egger | 152 | 901 | 184176 |
Don W. Cleveland | 152 | 444 | 84737 |
Ashok Kumar | 151 | 5654 | 164086 |
Kurt Wüthrich | 143 | 739 | 103253 |
Thomas J. Smith | 140 | 1775 | 113919 |
Robert Huber | 139 | 671 | 73557 |
Peter Robmann | 135 | 1438 | 97569 |
Ernst Detlef Schulze | 133 | 670 | 69504 |
Michael Levine | 129 | 586 | 55963 |
Claudio Santoni | 129 | 1027 | 80598 |
Pablo Garcia-Abia | 126 | 989 | 78690 |