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Institution

University of Bath

EducationBath, Bath and North East Somerset, United Kingdom
About: University of Bath is a education organization based out in Bath, Bath and North East Somerset, United Kingdom. It is known for research contribution in the topics: Population & Photonic-crystal fiber. The organization has 15830 authors who have published 39608 publications receiving 1358769 citations. The organization is also known as: Bath University.


Papers
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Journal ArticleDOI
TL;DR: The basic principles behind various physical methods for gene transfer are described and the advantages and performance of such approaches, compared to other transfection systems, are assessed.

404 citations

Journal ArticleDOI
TL;DR: In this paper, the authors propose a conceptualisation for supply strategy, an explanation for how organizations arrange and conduct themselves within modern economic environments, in order to satisfy markets in the long and short terms.
Abstract: This article proposes a conceptualisation for supply strategy – an explanation for how organisations arrange and conduct themselves within modern economic environments, in order to satisfy markets in the long and short terms. After an explanation of the emerging global environment within which organisations must compete, the previous approaches to explaining this area of business are explored and found to be insufficient for the new context. There follows a conceptualisation and an account of new, supporting research – a Delphi survey, conducted to test, extend and validate some of the features of the concept. Finally, some suggestions are made for the further development of supply strategy as a useful subject area for managers and researchers.

404 citations

Journal ArticleDOI
TL;DR: Self-emulsifying drug delivery systems (SEDDSs) represent a possible alternative to traditional oral formulations of lipophilic compounds and improved the reproducibility of the plasma profile in terms of the maximum plasma concentration (Cmax) and the time to reach the maximum concentration (tmax).
Abstract: Self-emulsifying drug delivery systems (SEDDSs) represent a possible alternative to traditional oral formulations of lipophilic compounds. In the present study, a lipophilic compound, WIN 54954, was formulated in a medium chain triglyceride oil/nonionic surfactant mixture which exhibited self-emulsification under conditions of gentle agitation in an aqueous medium. The efficiency of emulsification was studied using a laser diffraction sizer to determine particle size distributions of the resultant emulsions. An optimized formulation which consisted of 25% (w/w) surfactant, 40% (w/w) oil, and 35% (w/w) WIN 54954 emulsified rapidly with gentle agitation in 0.1 N HCl (37 degrees C), producing dispersions with mean droplet diameters of less than 3 microns. The self-emulsifying preparation was compared to a polyethylene glycol 600 (PEG 600) solution formulation by administering each as prefilled soft gelatin capsules to fasted beagle dogs in a parallel crossover study. Pharmacokinetic parameters were determined and the absolute bioavailability of the drug was calculated by comparison to an i.v. injection. The SEDDS improved the reproducibility of the plasma profile in terms of the maximum plasma concentration (Cmax) and the time to reach the maximum concentration (tmax). There was no significant difference in the absolute bioavailability of WIN 54954 from either the SEDDS or the PEG formulations.

404 citations

Journal ArticleDOI
TL;DR: In this paper, the authors use a systematic review to develop a research framework which integrates intellectual capital resources (organizational, social and human capital) across various levels of analysis (organization, group and individual).
Abstract: Ambidexterity is of central importance to the competitive advantage of the firm, yet to date there is limited understanding of how it is managed. The theorization of ambidexterity is inadequate for complex, practical realities and, in turn, this hinders the way in which it can aid the management of ambidexterity in practice. This paper asks: What are the mechanisms for achieving ambidexterity? The authors use a systematic review to develop a research framework which integrates intellectual capital resources (organizational, social and human capital) across various levels of analysis (organization, group and individual). This review extends understanding of the generic mechanisms (i.e. temporal, structural and contextual ambidexterity) that dominate the literature. This allows for a more fine-grained understanding of how ambidexterity is achieved and enables avenues for further research to be identified.

403 citations

Journal ArticleDOI
TL;DR: The relationships between structure, mechanism of action and therapeutic use of botulinum neurotoxins are discussed.

403 citations


Authors

Showing all 16056 results

NameH-indexPapersCitations
Michael Grätzel2481423303599
Brenda W.J.H. Penninx1701139119082
Amartya Sen149689141907
Gilbert Laporte12873062608
Andre K. Geim125445206833
Matthew Jones125116196909
Benoît Roux12049362215
Stephen Mann12066955008
Bruno S. Frey11990065368
Raymond A. Dwek11860352259
David Cutts11477864215
John Campbell107115056067
David Chandler10742452396
Peter H.R. Green10684360113
Huajian Gao10566746748
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202386
2022404
20212,474
20202,371
20192,144
20181,972