Institution
University of Bedfordshire
Education•Luton, Bedford, United Kingdom•
About: University of Bedfordshire is a education organization based out in Luton, Bedford, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 3860 authors who have published 6079 publications receiving 143448 citations. The organization is also known as: University of Luton.
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TL;DR: In this paper, a case-control study with detailed assessment of diabetes and functional status was undertaken, where the authors explored the nature of functional impairment in older people with diabetes and explored the effect of functional impairments on their mobility.
Abstract: OBJECTIVE—To explore the nature of functional impairment in older people with diabetes.
RESEARCH DESIGN AND METHODS—A population-based case-control study with detailed assessment of diabetes and functional status was undertaken.
RESULTS—Altogether, 403 case subjects and 403 matched control subjects were studied (median age 75 years, 51% female). Subjects with diabetes had more comorbidities than control subjects (mean 2.5 vs. 1.9, P < 0.0001) and were more likely to have severe functional impairment (4 vs. 1%, Barthel score <5, P < 0.001). Health status pertaining to physical function was reduced in case subjects (SF36 60 vs. 40, P < 0.0001). In a multivariate model controlling for age, hypertension, cerebrovascular disease, chronic obstructive pulmonary disease, cancer, osteoarthritis, and dementia, diabetes remained significantly associated with mobility limitation (odds ratio 2.1, P < 0.001).
CONCLUSIONS—Older people with diabetes have considerable functional impairment associated with reduced health status. This population may benefit from comprehensive geriatric assessment and tailored diabetes management.
153 citations
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TL;DR: The authors explored the relationship between environmental regulation and stakeholder pressures and performance considering the mediating role of environmental innovation strategy and the moderated role of marketing capability, and found that marketing capability significantly moderates the relationship of environmental regulation on financial performance.
153 citations
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TL;DR: In this paper, the authors identify critical success factors for tourism partnerships between the public and the private sectors at tourism destinations and assess the performance of such arrangements, using a case study approach, with a tourism partnership in York constituting its subject.
151 citations
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TL;DR: The high level of acid tolerance exhibited by survivors of a nontoxigenic isolate of Escherichia coliO157:H7 at low pH was found to be quickly lost once they were transferred to conditions which permitted growth to resume, indicating that they were not mutants.
Abstract: Survival of a nontoxigenic isolate of Escherichia coli O157:H7 at low pH (pH 3.0) was examined over prolonged time periods for each of three population types: exponential-phase cells, stationary-phase cells, and acid-adapted exponential-phase cells. In each population, approximately 5 x 10(4) CFU ml-1 were detected after a 24-h incubation at pH 3.0. Even after 3 days at pH 3.0, significant numbers of survivors from each of the three populations could be detected. The high level of acid tolerance exhibited by these survivors was found to be quickly lost once they were transferred to conditions which permitted growth to resume, indicating that they were not mutants. Proton flux measurements on the three populations of cells revealed that the initial rates of viability loss at pH 3.0 correlated well with net proton accumulation. Cells showing a high initial rate of viability loss (exponential-phase cells) accumulated protons at the highest rate, whereas resistant populations (adapted or stationary-phase cells) accumulated protons only slowly. Differences in the protein composition of the cell envelope between the three populations were studied by two-dimensional polyacrylamide gel electrophoresis. Complex differences in the pattern of proteins expressed by each population were uncovered. The implications of these findings are discussed in the context of a possible model accounting for acid tolerance in this important food-borne pathogen.
151 citations
Authors
Showing all 3892 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jie Zhang | 178 | 4857 | 221720 |
Oscar H. Franco | 111 | 822 | 66649 |
Timothy J. Foster | 98 | 420 | 32338 |
Christopher P. Denton | 95 | 675 | 42040 |
Ian Kimber | 91 | 620 | 28629 |
Michael J. Gidley | 86 | 420 | 24313 |
David Carling | 86 | 186 | 45066 |
Anthony Turner | 79 | 489 | 24734 |
Rhys E. Green | 78 | 285 | 30428 |
Vijay Kumar Thakur | 74 | 375 | 17719 |
Dave J. Adams | 73 | 283 | 19526 |
Naresh Magan | 72 | 400 | 17511 |
Aedin Cassidy | 70 | 218 | 17788 |
David A. Basketter | 70 | 325 | 16639 |
Richard C. Strange | 67 | 249 | 17805 |