University of Bedfordshire

About: University of Bedfordshire is a education organization based out in Luton, Bedford, United Kingdom. It is known for research contribution in the topics: Population & Social work. The organization has 3860 authors who have published 6079 publications receiving 143448 citations. The organization is also known as: University of Luton.

Paediatric and adult-onset male hypogonadism

Abstract: The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as well as exocrine function, with spermatogenesis. Conditions impairing the hypothalamic–pituitary–gonadal axis during paediatric or pubertal life may result in delayed puberty. Late-onset hypogonadism is a clinical condition in the ageing male combining low concentrations of circulating testosterone and specific symptoms associated with impaired hormone production. Testosterone therapy for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remains a matter of debate because of unclear indications for replacement, uncertain efficacy and potential risks. This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypogonadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development. Male hypogonadism is a disorder associated with low testosterone levels and impaired spermatogenesis. The condition can arise from inherent defects in the testes or abnormalities in the regulation of testosterone secretion at the hypothalamic or pituitary level. This Primer summarizes the conditions that can lead to hypogonadism in boys and men.

The resource‐based view of strategy and its value to practising managers

Abstract: •A dominant theoretical paradigm in academic strategic management circles is the Resource-Based View (RBV). This paper reviews the literature of this position and the extent to which the RBV may be seen as a source of practical guidance for managers seeking competitive advantage and strategic success. •The theories of management academics should be of practical value to managers, otherwise such theories are of limited value. The test of the validity of theorizing about management is whether the theories produced help to improve the art of management. That is the criterion adopted in this paper. •The RBV is an ‘inside-out’ perspective, according to which, competitive success lies within the hands of managers themselves and it is from the point of view of practising managers that this paper examines competitiveness. Consequently, the assessment of the RBV will be a purely instrumental one. Does it help managers to manage better? Copyright © 2002 John Wiley & Sons, Ltd.

Astronomical calibration of the Jurassic time-scale from cyclostratigraphy in British mudrock formations

Abstract: Three British Jurassic mudrock formations have been investigated, via timeseries analysis, for evidence of sedimentary cyclicity related to orbitalclimatic (Milankovitch) cyclicity: the Blue Lias, ...

Linking Business Analytics to Decision Making Effectiveness: A Path Model Analysis

Abstract: While business analytics is being increasingly used to gain data-driven insights to support decision making, little research exists regarding the mechanism through which business analytics can be used to improve decision-making effectiveness (DME) at the organizational level. Drawing on the information processing view and contingency theory, this paper develops a research model linking business analytics to organizational DME. The research model is tested using structural equation modeling based on 740 responses collected from U.K. businesses. The key findings demonstrate that business analytics, through the mediation of a data-driven environment, positively influences information processing capability, which in turn has a positive effect on DME. The findings also demonstrate that the paths from business analytics to DME have no statistical differences between large and medium companies, but some differences between manufacturing and professional service industries. Our findings contribute to the business analytics literature by providing useful insights into business analytics applications and the facilitation of data-driven decision making. They also contribute to managers’ knowledge and understanding by demonstrating how business analytics should be implemented to improve DME.