Institution
University of Bedfordshire
Education•Luton, Bedford, United Kingdom•
About: University of Bedfordshire is a education organization based out in Luton, Bedford, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 3860 authors who have published 6079 publications receiving 143448 citations. The organization is also known as: University of Luton.
Papers published on a yearly basis
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TL;DR: This paper critically reviews the entire process of risk assessment by in vitro toxicology, encompassing ongoing and future developments, with major emphasis on cytotoxicity, cellular responses, toxicokinetics, modelling, metabolism, cancer-related endpoints, developmental toxicity, prediction of allergenicity, and finally, development and application of biomarkers.
422 citations
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TL;DR: A detailed investigation into the behavior of dodecane-water emulsions stabilized by a mixture of silica nanoparticles and pure cationic surfactant has been made, showing that both emulsifiers prefer to stabilize o/w emulsion phase inversion and synergism is displayed in these mixtures.
Abstract: Using a range of complementary experiments, a detailed investigation into the behavior of dodecane-water emulsions stabilized by a mixture of silica nanoparticles and pure cationic surfactant has been made. Both emulsifiers prefer to stabilize o/w emulsions. At high pH, particles are ineffective emulsifiers, whereas surfactant-stabilized emulsions become increasingly stable to coalescence with concentration. In mixtures, no emulsion phase inversion occurs although synergism between the emulsifiers leads to enhanced stability at either fixed surfactant concentration or fixed particle concentration. Emulsions are most stable under conditions where particles have negligible charge and are most flocculated. Freeze fracture scanning electron microscopy confirms the presence of particle flocs at drop interfaces. At low pH, particles and surfactant are good emulsifiers alone. Synergism is also displayed in these mixtures, with the extent of creaming being minimum when particles are most flocculated. Experiments have been undertaken in order to offer an explanation for the latter synergy. By determining the adsorption isotherm of surfactant on particles in water, we show that surfactant addition initially leads to particle flocculation followed by re-dispersion. Using suitable contact angle measurements at oil-water-solid interfaces, we show that silica surfaces initially become increasingly hydrophobic upon surfactant addition, as well as surfactant adsorption lowering the oil-water interfacial tension. A competition exists between the influence of surfactant on the contact angle and the tension in the attachment energy of a particle to the interface.
420 citations
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TL;DR: Benefits of thermal processing include inactivation of food-borne pathogens, natural toxins or other detrimental constituents, prolongation of shelf-life, improved digestibility and bioavailability of nutrients, improved palatability, taste, texture and flavour and enhanced functional properties.
Abstract: The manuscript reviews beneficial aspects of food processing with main focus on cooking/heat treatment, including other food-processing techniques (e.g. fermentation). Benefits of thermal processing include inactivation of food-borne pathogens, natural toxins or other detrimental constituents, prolongation of shelf-life, improved digestibility and bioavailability of nutrients, improved palatability, taste, texture and flavour and enhanced functional properties, including augmented antioxidants and other defense reactivity or increased antimicrobial effectiveness. Thermal processing can bring some unintentional undesired consequences, such as losses of certain nutrients, formation of toxic compounds (acrylamide, furan or acrolein), or of compounds with negative effects on flavour perception, texture or colour. Heat treatment of foods needs to be optimized in order to promote beneficial effects and to counteract, to the best possible, undesired effects. This may be achieved more effectively/sustainably by consistent fine-tuning of technological processes rather than within ordinary household cooking conditions. The most important identified points for further study are information on processed foods to be considered in epidemiological work, databases should be built to estimate the intake of compounds from processed foods, translation of in-vitro results to in-vivo relevance for human health should be worked on, thermal and non-thermal processes should be optimized by application of kinetic principles.
392 citations
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TL;DR: It is demonstrated that chondroitin sulphates exhibit remarkable connective tissue specificity and furthermore there is evidence that some proteoglycans may predominantly carry only one type of chondDetroitin sulphate chain.
Abstract: Chondroitin sulphate proteoglycans are widespread connective tissue components1–4 and chemical analysis of cartilage and other proteoglycans has demonstrated molecular speciation involving the degree and position of sulphation of the carbohydrate chains5,6. This may, in turn, affect the properties of the glycpsaminoglycan (GAG), particularly with respect to self-association and interactions with other extracellular matrix components6,7. Interactions with specific molecules from different connective tissue types, such as the collagens8,9 and their associated glycoproteins10,11, could be favoured by particular charge organizations on the GAG molecule endowed by the sulphate groups. So far, it has not been possible to identify and map chondroitins of differing sulphation in tissues, but we have now raised three monoclonal antibodies which specifically recognize unsulphated, 4-sulphated and 6-sulphated chondroitin and dermatan sulphate. These provide novel opportunities to study the in vivo distribution of chondroitin sulphate proteoglycans. We demonstrate that chondroitin sulphates exhibit remarkable connective tissue specificity and furthermore provide evidence that some proteoglycans may predominantly carry only one type of chondroitin sulphate chain.
391 citations
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TL;DR: No evidence is found that MBCT with support to taper or discontinue antidepressant treatment (MBCT-TS) is superior to maintenance antidepressant treatment for the prevention of depressive relapse in individuals at risk for depressive relapse or recurrence.
385 citations
Authors
Showing all 3892 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jie Zhang | 178 | 4857 | 221720 |
Oscar H. Franco | 111 | 822 | 66649 |
Timothy J. Foster | 98 | 420 | 32338 |
Christopher P. Denton | 95 | 675 | 42040 |
Ian Kimber | 91 | 620 | 28629 |
Michael J. Gidley | 86 | 420 | 24313 |
David Carling | 86 | 186 | 45066 |
Anthony Turner | 79 | 489 | 24734 |
Rhys E. Green | 78 | 285 | 30428 |
Vijay Kumar Thakur | 74 | 375 | 17719 |
Dave J. Adams | 73 | 283 | 19526 |
Naresh Magan | 72 | 400 | 17511 |
Aedin Cassidy | 70 | 218 | 17788 |
David A. Basketter | 70 | 325 | 16639 |
Richard C. Strange | 67 | 249 | 17805 |