Showing papers by "University of Birmingham published in 2022"
TL;DR: In this article , the authors provide a comprehensive analysis of the dynamics between energy transition and COVID-19 around the world and propose a low-carbon energy transition roadmap in the post-pandemic era.
143 citations
TL;DR: The Post-hospitalisation COVID-19 study (PHOSP-COVID) as mentioned in this paper is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID19 across the UK.
118 citations
TL;DR: In this paper , the authors use measurements from over 4,735 globally distributed Global Navigation Satellite System receivers to track the progression of traveling ionospheric disturbances associated with the 15 January 2022 Hunga Tonga-Hunga Ha'apai submarine volcanic eruption.
Abstract: In this study, we use measurements from over 4,735 globally distributed Global Navigation Satellite System receivers to track the progression of traveling ionospheric disturbances (TIDs) associated with the 15 January 2022 Hunga Tonga-Hunga Ha'apai submarine volcanic eruption. We identify two distinct Large Scale traveling ionospheric disturbances (LSTIDs) and several subsequent Medium Scale traveling ionospheric disturbances (MSTIDs) that propagate radially outward from the eruption site. Within 3,000 km of epicenter, LSTIDs of >1,600 km wavelengths are initially observed propagating at speeds of ∼950 and ∼555 ms−1, before substantial slowing to ∼600 and ∼390 ms−1, respectively. MSTIDs with speeds of 200–400 ms−1 are observed for 6 hrs following eruption, the first of which comprises the dominant global ionospheric response and coincides with the atmospheric surface pressure disturbance associated with the eruption. These are the first results demonstrating the global impact of the Tonga eruption on the ionospheric state.
88 citations
TL;DR: A framework to aggregate and transfer diagnostic knowledge from multiple source machines by combining multiple partial distribution adaptation sub-networks (PDA-Subnets) and a multi-source diagnostic knowledge fusion module is proposed.
66 citations
TL;DR: In this paper, the authors explored the dynamic effect of non-renewable energy, renewable energy, economic growth, and foreign direct investment on environmental degradation in twenty selected African countries over the period 2000-2015.
51 citations
01 Jun 2022
TL;DR: In this paper , the authors conducted a population-based test-negative case-control study of the UK Coronavirus Cancer Evaluation Project (UKCCEP), and extracted data from the UKCCEP registry on all SARS-CoV-2 PCR test results (from the Second Generation Surveillance System), vaccination records from the National Immunisation Management Service, patient demographics, and cancer records from England, UK, from Dec 8, 2020, to Oct 15, 2021.
Abstract: BackgroundPeople with cancer are at increased risk of hospitalisation and death following infection with SARS-CoV-2. Therefore, we aimed to conduct one of the first evaluations of vaccine effectiveness against breakthrough SARS-CoV-2 infections in patients with cancer at a population level.MethodsIn this population-based test-negative case-control study of the UK Coronavirus Cancer Evaluation Project (UKCCEP), we extracted data from the UKCCEP registry on all SARS-CoV-2 PCR test results (from the Second Generation Surveillance System), vaccination records (from the National Immunisation Management Service), patient demographics, and cancer records from England, UK, from Dec 8, 2020, to Oct 15, 2021. Adults (aged ≥18 years) with cancer in the UKCCEP registry were identified via Public Health England's Rapid Cancer Registration Dataset between Jan 1, 2018, and April 30, 2021, and comprised the cancer cohort. We constructed a control population cohort from adults with PCR tests in the UKCCEP registry who were not contained within the Rapid Cancer Registration Dataset. The coprimary endpoints were overall vaccine effectiveness against breakthrough infections after the second dose (positive PCR COVID-19 test) and vaccine effectiveness against breakthrough infections at 3–6 months after the second dose in the cancer cohort and control population.FindingsThe cancer cohort comprised 377 194 individuals, of whom 42 882 had breakthrough SARS-CoV-2 infections. The control population consisted of 28 010 955 individuals, of whom 5 748 708 had SARS-CoV-2 breakthrough infections. Overall vaccine effectiveness was 69·8% (95% CI 69·8–69·9) in the control population and 65·5% (65·1–65·9) in the cancer cohort. Vaccine effectiveness at 3–6 months was lower in the cancer cohort (47·0%, 46·3–47·6) than in the control population (61·4%, 61·4–61·5).InterpretationCOVID-19 vaccination is effective for individuals with cancer, conferring varying levels of protection against breakthrough infections. However, vaccine effectiveness is lower in patients with cancer than in the general population. COVID-19 vaccination for patients with cancer should be used in conjunction with non-pharmacological strategies and community-based antiviral treatment programmes to reduce the risk that COVID-19 poses to patients with cancer.FundingUniversity of Oxford, University of Southampton, University of Birmingham, Department of Health and Social Care, and Blood Cancer UK. People with cancer are at increased risk of hospitalisation and death following infection with SARS-CoV-2. Therefore, we aimed to conduct one of the first evaluations of vaccine effectiveness against breakthrough SARS-CoV-2 infections in patients with cancer at a population level. In this population-based test-negative case-control study of the UK Coronavirus Cancer Evaluation Project (UKCCEP), we extracted data from the UKCCEP registry on all SARS-CoV-2 PCR test results (from the Second Generation Surveillance System), vaccination records (from the National Immunisation Management Service), patient demographics, and cancer records from England, UK, from Dec 8, 2020, to Oct 15, 2021. Adults (aged ≥18 years) with cancer in the UKCCEP registry were identified via Public Health England's Rapid Cancer Registration Dataset between Jan 1, 2018, and April 30, 2021, and comprised the cancer cohort. We constructed a control population cohort from adults with PCR tests in the UKCCEP registry who were not contained within the Rapid Cancer Registration Dataset. The coprimary endpoints were overall vaccine effectiveness against breakthrough infections after the second dose (positive PCR COVID-19 test) and vaccine effectiveness against breakthrough infections at 3–6 months after the second dose in the cancer cohort and control population. The cancer cohort comprised 377 194 individuals, of whom 42 882 had breakthrough SARS-CoV-2 infections. The control population consisted of 28 010 955 individuals, of whom 5 748 708 had SARS-CoV-2 breakthrough infections. Overall vaccine effectiveness was 69·8% (95% CI 69·8–69·9) in the control population and 65·5% (65·1–65·9) in the cancer cohort. Vaccine effectiveness at 3–6 months was lower in the cancer cohort (47·0%, 46·3–47·6) than in the control population (61·4%, 61·4–61·5). COVID-19 vaccination is effective for individuals with cancer, conferring varying levels of protection against breakthrough infections. However, vaccine effectiveness is lower in patients with cancer than in the general population. COVID-19 vaccination for patients with cancer should be used in conjunction with non-pharmacological strategies and community-based antiviral treatment programmes to reduce the risk that COVID-19 poses to patients with cancer.
43 citations
TL;DR: In this article, a thermal energy storage system based on SiO2 nanoparticles decorated LiNO3/NaCl eutectics inlaid in three-dimensional (3D) hierarchical ultralight silicon carbide (SiC) foams is proposed.
29 citations
TL;DR: In this paper, a molecular dynamics simulation method is established to predict the structural, diffusive and thermal properties of composite PCMs based on CNTs, and the authors found that the PCMs are preferentially distributed as either one or two ring-shaped layers that discretely separated from the CNT wall with a distance of 3.8 A and 8.0 A, respectively.
27 citations
TL;DR: The first wave of the COVID-19 pandemic caused millions of elective surgical procedures to be cancelled worldwide during the first wave, and the National Health Service (NHS) in England has not returned to pre-pandemic elective surgery activity levels as mentioned in this paper .
27 citations
TL;DR: In this article, the authors evaluate the tail risk and systemic risk of technology firms using the univariate extreme value theory (EVT) to determine equity tail risk, and conclude that technology firms are riskier than finance firms.
23 citations
TL;DR: In this paper, a transferable representation control model is proposed by incorporating two promising artificial intelligence technologies, adaptive neural fuzzy inference system and Gaussian process regression, where the former applies k-fold cross valudation to build a neural fuzzy system for real-time implementation of offline optimization result, and the later connects the Neural fuzzy system with a deeper architecture to transfer the offline optimization knowledge learnt at source domain to new target domains.
TL;DR: In this article , the physics of SCFTs arising from isolated hypersurface singularities are studied in detail, and a Mathematica code is provided to compute key quantities for any canonical SCFT, including the 5d rank, the 4d Coulomb branch spectrum and central charges, higher-form symmetries in 4d and 5d, and crepant resolutions.
Abstract: Compactification of M-theory and of IIB string theory on threefold canonical singularities gives rise to superconformal field theories (SCFTs) in 5d and 4d, respectively. The resolutions and deformations of the singularities encode salient features of the SCFTs and of their moduli spaces. In this paper, we build on Part 0 of this series (arXiv:2007.15600) and further explore the physics of SCFTs arising from isolated hypersurface singularities. We study in detail these canonical isolated hypersurface singularities that admit a smooth Calabi-Yau (crepant) resolution. Their 5d and 4d physics is discussed and their 3d reduction and mirrors (the magnetic quivers) are determined in many cases. As an explorative tool, we provide a Mathematica code which computes key quantities for any canonical isolated hypersurface singularity, including the 5d rank, the 4d Coulomb branch spectrum and central charges, higher-form symmetries in 4d and 5d, and crepant resolutions.
Ludwig Maximilian University of Munich1, University of Tartu2, University of Helsinki3, Keio University4, Bielefeld University5, Humboldt University of Berlin6, University of Wisconsin-Madison7, Konkuk University8, Agnes Scott College9, Aix-Marseille University10, University of Paris III: Sorbonne Nouvelle11, Federal University of Paraná12, University of Southern Denmark13, RMIT University14, University of KwaZulu-Natal15, University of Birmingham16
TL;DR: This article reported an online experiment that tested the bouba/kiki effect across speakers of 25 languages representing nine language families and 10 writing systems, and found strong evidence for the effect across languages, with bouba eliciting more congruent responses than kiki.
Abstract: The bouba/kiki effect-the association of the nonce word bouba with a round shape and kiki with a spiky shape-is a type of correspondence between speech sounds and visual properties with potentially deep implications for the evolution of spoken language. However, there is debate over the robustness of the effect across cultures and the influence of orthography. We report an online experiment that tested the bouba/kiki effect across speakers of 25 languages representing nine language families and 10 writing systems. Overall, we found strong evidence for the effect across languages, with bouba eliciting more congruent responses than kiki. Participants who spoke languages with Roman scripts were only marginally more likely to show the effect, and analysis of the orthographic shape of the words in different scripts showed that the effect was no stronger for scripts that use rounder forms for bouba and spikier forms for kiki. These results confirm that the bouba/kiki phenomenon is rooted in crossmodal correspondence between aspects of the voice and visual shape, largely independent of orthography. They provide the strongest demonstration to date that the bouba/kiki effect is robust across cultures and writing systems. This article is part of the theme issue 'Voice modulation: from origin and mechanism to social impact (Part II)'.
University of York1, University of Freiburg2, University of Stirling3, University of Nottingham4, Lancaster University5, University of Cambridge6, University of Granada7, University of Birmingham8, Universidade Federal de Minas Gerais9, University of Antwerp10, University of Hamburg11, University of Adelaide12, University of Sheffield13
TL;DR: The metaheuristics "In the Large" project as discussed by the authors aims to support the development, analysis, and comparison of new approaches in optimization research by providing extensible algorithm templates that support reuse without modification, white box problem descriptions that provide generic support for the injection of domain specific knowledge, and remotely accessible frameworks, components and problems.
University of British Columbia1, European Gravitational Observatory2, The University of Texas Rio Grande Valley3, University of Wisconsin–Milwaukee4, California Institute of Technology5, International Centre for Theoretical Sciences6, University of Arizona7, Cardiff University8, Haverford College9, University of Birmingham10, INFN Sezione di Padova11, University of Hamburg12, Laboratoire des Matériaux Avancés13, Université libre de Bruxelles14, Swinburne University of Technology15, Northwestern University16, University of Texas at Austin17, Brera Astronomical Observatory18, University of the Balearic Islands19, Laser Interferometer Gravitational Wave Observatory20, IFAE21, McGill University22, Astroparticle and Cosmology Laboratory23, The Chinese University of Hong Kong24, University of Western Australia25, Paris Diderot University26, University of Florida27, INFN Sezione di Pisa28, Southern University and A&M College29, National Institute for Space Research30, Utrecht University31, Pennsylvania State University32, KEK33, University of Cambridge34, National Institute for Subatomic Physics35, Rochester Institute of Technology36, Observatoire de la Côte d’Azur37, INFN Sezione di Roma I38, University of Tokyo39, University of Glasgow40, Raja Ramanna Centre for Advanced Technology41, INFN Sezione di Roma II42, Louisiana State University43, INFN Sezione di Napoli44, Massachusetts Institute of Technology45, National Central University46
TL;DR: In this paper , the frequency and frequency time-derivative of the gravitational wave signals from 18 pulsars in data from LIGO and Virgo's third observing run (O3) was investigated.
Abstract: Isolated neutron stars that are asymmetric with respect to their spin axis are possible sources of detectable continuous gravitational waves. This paper presents a fully-coherent search for such signals from eighteen pulsars in data from LIGO and Virgo's third observing run (O3). For known pulsars, efficient and sensitive matched-filter searches can be carried out if one assumes the gravitational radiation is phase-locked to the electromagnetic emission. In the search presented here, we relax this assumption and allow the frequency and frequency time-derivative of the gravitational waves to vary in a small range around those inferred from electromagnetic observations. We find no evidence for continuous gravitational waves, and set upper limits on the strain amplitude for each target. These limits are more constraining for seven of the targets than the spin-down limit defined by ascribing all rotational energy loss to gravitational radiation. In an additional search we look in O3 data for long-duration (hours-months) transient gravitational waves in the aftermath of pulsar glitches for six targets with a total of nine glitches. We report two marginal outliers from this search, but find no clear evidence for such emission either. The resulting duration-dependent strain upper limits do not surpass indirect energy constraints for any of these targets.
TL;DR: In this article , the authors present a systematic review that aims to evaluate the effectiveness of manual therapy applied specifically to the craniomandibular structures (Cranio-Mandibular Manual Therapy [CMMT]) on pain and maximum mouth opening in people with TMD.
Abstract: Within physical therapy, manual therapy is known to be effective for managing temporomandibular disorders (TMDs). However, manual therapy is a broad term including different approaches applied to different body regions.This is the first systematic review that aims to evaluate the effectiveness of manual therapy applied specifically to the craniomandibular structures (Cranio-Mandibular Manual Therapy [CMMT]) on pain and maximum mouth opening in people with TMD.This systematic review was developed based on a pre-determined published protocol which was prospectively registered with PROSPERO (CRD42019160213). A search of MEDLINE, Embase, CINAHL, ZETOC, Web of Science, SCOPUS, PEDro, PubMed, Cochrane Library and Best Evidence, EBM reviews-Cochrane Central Register of Controlled Trials, Index to Chiropractic Literature ChiroAccess and Google Scholar databases was conducted from inception until October 2020. Randomised controlled trials comparing the effect of CMMT on pain and maximum mouth opening versus other types of treatment in TMDs were included. Two reviewers independently screened articles for inclusion, extracted data, assessed risk of bias with the revised Cochrane risk of bias tool for randomised trials and evaluated the overall quality of evidence with the Grading of Recommendations, Assessment, Development and Evaluations.A total of 2720 records were screened, of which only 6 (293 participants) satisfied the inclusion criteria. All studies showed some concerns in risk of bias, except for one, which was high risk of bias. The overall quality of evidence was very low for all outcomes because of high heterogeneity and small sample sizes. All studies showed a significant improvement in pain and maximum mouth opening for CMMT from baseline in the mid-term, but only two showed superiority compared to other interventions. Given the high heterogeneity and small sample sizes of the included studies, a quantitative synthesis was not performed.There is the need for future high methodology research investigating different manual therapy techniques applied to different regions and different populations (e.g., chronic versus acute TMD) to determine what is most effective for pain and maximum mouth opening in patients with TMDs.
TL;DR: In this article , the nature of biological and chemical reactions occurring in such contexts with a view to a classification of types of behaviour and thus types of material was reviewed. But the authors concluded that bioactivity depends solely on the modulation of a natural biological process, but excluding pharmaceutical action.
TL;DR: In this paper , the authors reported the synthesis of ultra-tough, reprocessable elastomers based on linear alternating polymers, which incorporated a rigid isohexide adjacent to urethane moieties.
Abstract: The remarkable elasticity and tensile strength found in natural elastomers are challenging to mimic. Synthetic elastomers typically feature covalently cross-linked networks (rubbers), but this hinders their reprocessability. Physical cross-linking via hydrogen bonding or ordered crystallite domains can afford reprocessable elastomers, but often at the cost of performance. Herein, we report the synthesis of ultra-tough, reprocessable elastomers based on linear alternating polymers. The incorporation of a rigid isohexide adjacent to urethane moieties affords elastomers with exceptional strain hardening, strain rate dependent behavior, and high optical clarity. Distinct differences were observed between isomannide and isosorbide-based elastomers where the latter displays superior tensile strength and strain recovery. These phenomena are attributed to the regiochemical irregularities in the polymers arising from their distinct stereochemistry and respective inter-chain hydrogen bonding.
TL;DR: In this paper , the outcomes of individuals with PID and SID following SARS-CoV-2 infection and treatment were collated and the overall mortality within the cohort was 17.7% (n = 55/310).
Abstract: Abstract In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry of cases to collate the outcomes of individuals with PID and SID following SARS-CoV-2 infection and treatment. A total of 310 cases of SARS-CoV-2 infection in individuals with PID or SID have now been reported in the UK. The overall mortality within the cohort was 17.7% (n = 55/310). Individuals with CVID demonstrated an infection fatality rate (IFR) of 18.3% (n = 17/93), individuals with PID receiving IgRT had an IFR of 16.3% (n = 26/159) and individuals with SID, an IFR of 27.2% (n = 25/92). Individuals with PID and SID had higher inpatient mortality and died at a younger age than the general population. Increasing age, low pre-SARS-CoV-2 infection lymphocyte count and the presence of common co-morbidities increased the risk of mortality in PID. Access to specific COVID-19 treatments in this cohort was limited: only 22.9% (n = 33/144) of patients admitted to the hospital received dexamethasone, remdesivir, an anti-SARS-CoV-2 antibody-based therapeutic (e.g. REGN-COV2 or convalescent plasma) or tocilizumab as a monotherapy or in combination. Dexamethasone, remdesivir, and anti-SARS-CoV-2 antibody-based therapeutics appeared efficacious in PID and SID. Compared to the general population, individuals with PID or SID are at high risk of mortality following SARS-CoV-2 infection. Increasing age, low baseline lymphocyte count, and the presence of co-morbidities are additional risk factors for poor outcome in this cohort.
TL;DR: In this paper, the combined effects of latent and sensible energy storage together with magnetization were investigated experimentally to increase the yield of the conventional solar still, which is limited to a daily yield of approximately 2-3.5 kg/m2/day.
University College Cork1, University Hospitals Bristol NHS Foundation Trust2, National University of Ireland, Galway3, University of Liverpool4, Mayo Clinic5, University of Bath6, Manchester Academic Health Science Centre7, Charité8, University of Oxford9, University of Birmingham10, Brown University11, Trinity College, Dublin12, Public Health Research Institute13, University of Bristol14
TL;DR: In this paper, the authors examined current practices in late-phase trials published in major medical journals and examined trialists' views about core outcome set (COS) use, and found that the most common barrier to COS use was trialist's own outcome preferences and choice (68%).
TL;DR: In this paper , the authors developed a new break detection toolbox that is applicable to different sized panels, easy to implement and robust to general forms of unobserved heterogeneity, including a structural change test, a break date estimator, and break date confidence interval.
Abstract: Dealing with structural breaks is an essential step in most empirical economic research. This is particularly true in panel data comprised of many cross-sectional units, which are all affected by major events. The COVID-19 pandemic has affected most sectors of the global economy; however, its impact on stock markets is still unclear. Most markets seem to have recovered while the pandemic is ongoing, suggesting that the relationship between stock returns and COVID-19 has been subject to structural break. It is therefore important to know if a structural break has occurred and, if it has, to infer the date of the break. Motivated by this last observation, the present article develops a new break detection toolbox that is applicable to different sized panels, easy to implement and robust to general forms of unobserved heterogeneity. The toolbox, which is the first of its kind, includes a structural change test, a break date estimator, and a break date confidence interval. Application to a panel covering 61 countries from January 3 to September 25, 2020, leads to the detection of a structural break that is dated to the first week of April. The effect of COVID-19 is negative before the break and zero thereafter, implying that while markets did react, the reaction was short-lived. A possible explanation is the quantitative easing programs announced by central banks all over the world in the second half of March. Supplementary materials for this article are available online.
TL;DR: In this paper, BaTiO3 nanocomposites developed at low nanofiller concentrations with their dielectric relaxations, charge transport dynamics and capacitive energy storage were investigated via dielectrics spectroscopy and dc charge-discharge experiments.
TL;DR: A review of evidence demonstrating a bidirectional relationship between memory and eating in humans and rodents can be found in this article, where it is shown that meal-related memory limits subsequent ingestive behavior and obesity is associated with impaired memory and disturbances in the hippocampus.
TL;DR: In this article, a reliable high-frequency induction heating-assisted single point incremental forming (SPIF) system was proposed to achieve high geometrical accuracy and formability for the Ti-6AI-4V alloy sheet.
TL;DR: In this article, the SARS-CoV-2 S HexaPro protein was analyzed and the site-specific N-linked glycosylation of the expression-enhanced version of the trimeric spike (S) glycoprotein was explored.
01 Apr 2022
TL;DR: The Retirement in Action (REACT) trial as discussed by the authors showed that a 12-month, group-based, multimodal physical activity and behavioural maintenance program could help prevent decline in physical function over a 24-month period.
Abstract: Mobility limitations in old age can greatly reduce quality of life, generate substantial health and social care costs, and increase mortality. Through the Retirement in Action (REACT) trial, we aimed to establish whether a community-based active ageing intervention could prevent decline in lower limb physical functioning in older adults already at increased risk of mobility limitation.In this pragmatic, multicentre, two-arm, single-blind, parallel-group, randomised, controlled trial, we recruited older adults (aged 65 years or older and who are not in full-time employment) with reduced lower limb physical functioning (Short Physical Performance Battery [SPPB] score 4-9) from 35 primary care practices across three sites (Bristol and Bath; Birmingham; and Devon) in England. Participants were randomly assigned to receive brief advice (three healthy ageing education sessions) or a 12-month, group-based, multimodal physical activity (64 1-h exercise sessions) and behavioural maintenance (21 45-min sessions) programme delivered by charity and community or leisure centre staff in local communities. Randomisation was stratified by site and adopted a minimisation approach to balance groups by age, sex, and SPPB score, using a centralised, online, randomisation algorithm. Researchers involved in data collection and analysis were masked but participants were not because of the nature of the intervention. The primary outcome was change in SPPB score at 24 months, analysed by intention to treat. This trial is registered with ISRCTN, ISRCTN45627165.Between June 20, 2016, and Oct 30, 2017, 777 participants (mean age 77·6 [SD 6·8] years; 66% female; mean SPPB score 7·37 [1·56]) were randomly assigned to the intervention (n=410) and control (n=367) groups. Primary outcome data at 24 months were provided by 628 (81%) participants (294 in the control group and 334 in the intervention group). At the 24-month follow-up, the SPPB score (adjusted for baseline SPPB score, age, sex, study site, and exercise group) was significantly greater in the intervention group (mean 8·08 [SD 2·87]) than in the control group (mean 7·59 [2·61]), with an adjusted mean difference of 0·49 (95% CI 0·06-0·92; p=0·014), which is just below our predefined clinically meaningful difference of 0·50. One adverse event was related to the intervention; the most common unrelated adverse events were heart conditions, strokes, and falls.For older adults at risk of mobility limitations, the REACT intervention showed that a 12-month physical activity and behavioural maintenance programme could help prevent decline in physical function over a 24-month period.National Institute for Health Research Public Health Research Programme (13/164/51).
TL;DR: In this paper , the authors found that stakeholder integration positively influences a firm's CSR commitment and this linkage is attenuated when uncertainty in CSR regulation is greater, and they also found that the firm's commitment mediates the relationship between stake-holder integration and CSP.
Abstract: In spite of the burgeoning literature on corporate social responsibility (CSR), little is known about the mechanism through which stakeholder integration affects corporate social performance (CSP). Our study fills this gap in the CSR literature by testing a model that explains this mechanism. Using data from 228 firms, we found that stakeholder integration positively influences a firm's CSR commitment and this linkage is attenuated when uncertainty in CSR regulation is greater. In addition, the results revealed that a firm's CSR commitment mediates the relationship between stakeholder integration and CSP. Theoretical and practical contributions are discussed.
TL;DR: In this article , the clinical outcomes of in-office needle arthroscopy (IONA) for the treatment of anterior ankle impingement in the office setting and also evaluate patient experience of the IONA procedure were evaluated using the following methods preoperatively and at final follow-up: the Foot and Ankle Outcome Scores (FAOS) and Patient-Reported Outcomes Measurement Information System (PROMIS) domains.
Abstract: To evaluate the clinical outcomes of in-office needle arthroscopy (IONA) for the treatment of anterior ankle impingement in the office setting and also evaluate patient experience of the IONA procedure.A prospectively collected database of 31 patients undergoing IONA for the treatment of anterior ankle impingement between January 2019 and January 2021 was retrospectively reviewed. Inclusion criteria for this study were patients ≥18 years of age, clinical history, physical examination, radiographic imaging, and magnetic resonance imaging findings consistent with anterior ankle impingement for which each patient underwent IONA and had a minimum of 12-month follow-up. Clinical outcomes were evaluated using the following methods preoperatively and at final follow-up: the Foot and Ankle Outcome Scores (FAOS) and Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference and Pain Intensity domains. A 5-point Likert scale regarding patient satisfaction with their IONA procedure was evaluated at final follow-up. Wilcoxon signed-rank test was performed to compare preoperative and postoperative outcome scores.In total, 31 patients were included in this study, including 18 male and 13 female, with a mean age of 41.7 ± 15.5 years (range, 17-69 years) and mean body mass index of 27.3 ± 5.7 (range, 19.37-41.5). The mean follow-up time was 15.5 ± 4.9 months. The mean postoperative FAOS-reported symptoms, pain, daily activities, sports activities, and quality of life were 79.4 ± 11.9, 82.9 ± 15.3, 83.5 ± 15.4, 71.9 ± 18.5 and 64.3 ± 21.4 at final follow-up respectively. Minimal clinically important difference was achieved by 84% of patients for FAOS pain, 77% for FAOS symptoms, 75% for FAOS Quality of Life, 74% for FAOS sports, 65% for PROMIS Pain Interference, 61% for FAOS Activities of Daily Living, and 42% for PROMIS Pain Intensity. Lastly, 29 patients (94 %) expressed willingness to undergo the same procedure again.The current study demonstrates that IONA treatment of anterior ankle impingement results in significant pain reduction, a low complication rate and excellent patient reported outcomes with high rates of return to work/sport. Additionally, IONA for anterior ankle impingement leads to high patient satisfaction with a significant willingness to undergo the same procedure again.IV, Case series study.