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Institution

University of Bologna

EducationBologna, Emilia-Romagna, Italy
About: University of Bologna is a education organization based out in Bologna, Emilia-Romagna, Italy. It is known for research contribution in the topics: Population & Galaxy. The organization has 38387 authors who have published 115176 publications receiving 3460869 citations. The organization is also known as: Università di Bologna & UNIBO.


Papers
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Journal ArticleDOI
TL;DR: The computational results show that the LP-relaxation of the two-stage optimization problem can be solved in a short time for a representative number of disruption scenarios, and it is demonstrated that the robust rolling stock circulation computed heuristically has total costs that are close to the LP lower bounds.
Abstract: In this paper we describe a two-stage optimization model for determining robust rolling stock circulations for passenger trains. Here robustness means that the rolling stock circulations can better deal with large disruptions of the railway system. The two-stage optimization model is formulated as a large mixed-integer linear programming (MILP) model. We first use Benders decomposition to determine optimal solutions for the LP-relaxation of this model. Then we use the cuts that were generated by the Benders decomposition for computing heuristic robust solutions for the two-stage optimization model. We call our method Benders heuristic. We evaluate our approach on the real-life rolling stock-planning problem of Netherlands Railways, the main operator of passenger trains in the Netherlands. The computational results show that, thanks to Benders decomposition, the LP-relaxation of the two-stage optimization problem can be solved in a short time for a representative number of disruption scenarios. In addition, they demonstrate that the robust rolling stock circulation computed heuristically has total costs that are close to the LP lower bounds. Finally, we discuss the practical effectiveness of the robust rolling stock circulation: When a large number of disruption scenarios were applied to these robust circulations and to the nonrobust optimal circulations, the former appeared to be much more easily recoverable than the latter.

84 citations

Journal ArticleDOI
TL;DR: It is found that the limbic thalamus has a strategic position in the central autonomie network running from the limbics cortical regions to the lower brain stem which regulates the body's homeostasis in an integrated fashion.
Abstract: The key clinical aspects of FFI, i.e. hypovigilance and attention deficit, inability to generate EEG sleep patterns, sympathetic hyperactivity and attenuation of vegetative and hormonal circadian oscillations, are related to selective atrophy of the anteroventral and mediodorsal thalamic nuclei. These nuclei constitute the limbic part of the thalamus interconnecting limbic and paralimbic regions of the cortex and other subcortical structures in the limbic system including the hypothalamus. The hypothalamus released from cortico-limbic control is shifted to a prevalence of activating, as opposed to deactivating, functions including loss of sleep, sympathetic hyperactivity and the attendant attenuation of autonomic circadian and endocrine oscillations. These findings document that the limbic thalamus has a strategic position in the central autonomic network running from the limbic cortical regions to the lower brain stem which regulates the body's homeostasis in an integrated fashion.

84 citations

Journal ArticleDOI
TL;DR: In this article, β-glucosidase was crosslinked with glutaraldehyde and exhibited a considerable affinity to chitosan, giving good immobilization yields (55-85%) while maintaining an optimum level of activity (550-850 U/g).

84 citations

Book ChapterDOI
25 May 2014
TL;DR: Graffoo, i.e., a graphical notation to develop OWL ontologies by means of yEd, a free editor for diagrams, is introduced.
Abstract: In this paper we introduce Graffoo, i.e., a graphical notation to develop OWL ontologies by means of yEd, a free editor for diagrams.

84 citations

Journal ArticleDOI
TL;DR: Quantum mechanics/molecular mechanics calculations based on ab initio multiconfigurational second order perturbation theory are employed to construct a computer model of Bacteriorhodopsin that reproduces the observed static and transient electronic spectra, the dipole moment changes, and the energy stored in the photocycle intermediate K.
Abstract: Quantum mechanics/molecular mechanics calculations based on ab initio multiconfigurational second order perturbation theory are employed to construct a computer model of Bacteriorhodopsin that reproduces the observed static and transient electronic spectra, the dipole moment changes, and the energy stored in the photocycle intermediate K. The computed reaction coordinate indicates that the isomerization of the retinal chromophore occurs via a complex motion accounting for three distinct regimes: (i) production of the excited state intermediate I, (ii) evolution of I toward a conical intersection between the excited state and the ground state, and (iii) formation of K. We show that, during stage ii, a space-saving mechanism dominated by an asynchronous double bicycle-pedal deformation of the C10═C11─C12═C13─C14═N moiety of the chromophore dominates the isomerization. On this same stage a N─H/water hydrogen bond is weakened and initiates a breaking process that is completed during stage iii.

84 citations


Authors

Showing all 39076 results

NameH-indexPapersCitations
Anil K. Jain1831016192151
H. S. Chen1792401178529
Stefan Schreiber1781233138528
Alvio Renzini16290895452
David H. Adams1551613117783
Roberto Romero1511516108321
Thomas E. Starzl150162591704
Paolo Boffetta148145593876
Kypros H. Nicolaides147130287091
J. Fraser Stoddart147123996083
Fabio Finelli147542111128
Jack Hirsh14673486332
Kjell Fuxe142147989846
Andrew Ivanov142181297390
Peter Lang140113698592
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023398
20221,031
20217,486
20207,098
20196,390
20185,737