Institution
University of Bordeaux
Education•Bordeaux, France•
About: University of Bordeaux is a education organization based out in Bordeaux, France. It is known for research contribution in the topics: Population & Laser. The organization has 28811 authors who have published 55536 publications receiving 1619635 citations. The organization is also known as: UB.
Topics: Population, Laser, Context (language use), Raman spectroscopy, Medicine
Papers published on a yearly basis
Papers
More filters
••
Memorial Sloan Kettering Cancer Center1, University College London2, National Taiwan University3, University of Southern California4, University of Ulsan5, Trakya University6, University of Bordeaux7, University of Bologna8, University of Amsterdam9, The Chinese University of Hong Kong10, University of California, San Francisco11
TL;DR: Treatment with cabozantinib resulted in longer overall survival and progression‐free survival than placebo among patients with previously treated advanced hepatocellular carcinoma, and the rate of high‐grade adverse events in the cabozaninib group was approximately twice that observed in the placebo group.
Abstract: Background Cabozantinib inhibits tyrosine kinases, including vascular endothelial growth factor receptors 1, 2, and 3, MET, and AXL, which are implicated in the progression of hepatocellul...
1,471 citations
••
Imperial College London1, Copenhagen Business School2, University of Gothenburg3, Royal Institute of Technology4, Polytechnic University of Valencia5, University of Bologna6, University of Turin7, Collegio Carlo Alberto8, University of Cambridge9, University of Kassel10, University of Strasbourg11, University of Bordeaux12
TL;DR: In this paper, the authors present a systematic review of research on academic scientists' involvement in collaborative research, contract research, consulting and informal relationships for university-industry knowledge transfer, which they refer as academic engagement.
1,470 citations
••
TL;DR: The first Fermi-LAT catalog (1FGL) as mentioned in this paper contains 1451 sources detected and characterized in the 100 MeV to 100 GeV range, and the threshold likelihood Test Statistic is 25, corresponding to a significance of just over 4 sigma.
Abstract: We present a catalog of high-energy gamma-ray sources detected by the Large Area Telescope (LAT), the primary science instrument on the Fermi Gamma-ray Space Telescope (Fermi), during the first 11 months of the science phase of the mission, which began on 2008 August 4. The First Fermi-LAT catalog (1FGL) contains 1451 sources detected and characterized in the 100 MeV to 100 GeV range. Source detection was based on the average flux over the 11 month period, and the threshold likelihood Test Statistic is 25, corresponding to a significance of just over 4 sigma. The 1FGL catalog includes source location regions, defined in terms of elliptical fits to the 95% confidence regions and power-law spectral fits as well as flux measurements in five energy bands for each source. In addition, monthly light curves are provided. Using a protocol defined before launch we have tested for several populations of gamma-ray sources among the sources in the catalog. For individual LAT-detected sources we provide firm identifications or plausible associations with sources in other astronomical catalogs. Identifications are based on correlated variability with counterparts at other wavelengths, or on spin or orbital periodicity. For the catalogs and association criteria that we have selected, 630 of the sources are unassociated. Care was taken to characterize the sensitivity of the results to the model of interstellar diffuse gamma-ray emission used to model the bright foreground, with the result that 161 sources at low Galactic latitudes and toward bright local interstellar clouds are flagged as having properties that are strongly dependent on the model or as potentially being due to incorrectly modeled structure in the Galactic diffuse emission.
1,412 citations
••
TL;DR: Postvaccination meningoencephalitis occurred without clear relation to serum anti-Aβ42 antibody titers and potential mechanisms such as T-cell and microglial activation may be responsible and are under consideration to develop a safer anti- Aβ immunotherapy for AD.
Abstract: Background: AD is characterized by cerebral deposition of β-amyloid plaques with amyloid β-peptide (Aβ) 42 as the major peptide constituent, along with neurofibrillary tangles and neuronal loss. In transgenic mice, active immunization against Aβ42 removes these plaques and improves cognitive function. A Phase I study in AD patients demonstrated good safety and tolerability of multiple injections of aggregated Aβ42 (AN1792) with QS-21 as adjuvant. Methods: Three hundred seventy-two patients with mild to moderate AD were randomized to receive IM injections of AN1792 or placebo (4:1) at baseline and at months 1, 3, 6, 9, and 12 in a multicenter Phase II safety, tolerability, and pilot efficacy study. Dosing was terminated after four early reports of meningoencephalitis, but follow-up continued. The study remains blinded, and further results will be reported after its termination. Results: Symptoms and laboratory findings consistent with meningoencephalitis occurred in 18 of 298 (6%) patients treated with AN1792 compared with 0 of 74 on placebo ( p = 0.020). Sixteen of the 18 had received two doses, one had received one dose, and one had received three doses of the study drug before symptoms occurred. The median latency from the first and last injections to symptoms was 75 and 40 days. No case occurred later than 6 months after the first immunization. Anti-Aβ42 antibody titers were not correlated with the occurrence or severity of symptoms or relapses. Twelve patients recovered to or close to baseline within weeks, whereas six remain with disabling cognitive or neurologic sequelae. All 18 patients remain alive to date (December 31, 2002), 6 months to >1 year after symptom onset. Conclusions: Postvaccination meningoencephalitis occurred without clear relation to serum anti-Aβ42 antibody titers. Potential mechanisms such as T-cell and microglial activation may be responsible and are under consideration to develop a safer anti-Aβ immunotherapy for AD.
1,367 citations
••
TL;DR: In this article, the state-of-the-art on generalized (or any order) derivatives in physics and engineering sciences is outlined for justifying the interest of the noninteger differentiation.
Abstract: The state-of-the-art on generalized (or any order) derivatives in physics and engineering sciences, is outlined for justifying the interest of the noninteger differentiation. The problems subsequent to its use in real-time operations are then set out so as to motivate the idea of synthesizing it by a recursive distribution of zeros and poles. An analysis of the existing work is also proposed to support this idea. A comprehensive study is given of the synthesis of differentiators with integer, noninteger, real or complex orders, and whose action is limited to any given frequency bandwidth. First, a definition, in the operational and frequency domains, of a frequency-band complex noninteger order differentiator, is given in a mathematical space with four dimensions which is a Banach algebra. Then, the determination of its synthesized form, by a recursive distribution of complex zeros and poles characterized by complex recursive factors, is presented. The complex noninteger differentiation order is expressed as a function of these recursive factors. The number of zeros and poles is calculated to be as low as possible while still ensuring the stability of the synthesized differentiator to be synthesized. A time validation is presented. Finally, guidelines are proposed for the conception of the synthesized differentiator.
1,361 citations
Authors
Showing all 28995 results
Name | H-index | Papers | Citations |
---|---|---|---|
Nicholas G. Martin | 192 | 1770 | 161952 |
George F. Koob | 171 | 935 | 112521 |
Daniel J. Jacob | 162 | 656 | 76530 |
Arthur W. Toga | 159 | 1184 | 109343 |
James M. Tour | 143 | 859 | 91364 |
Floyd E. Bloom | 139 | 616 | 72641 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
Stanley Nattel | 132 | 778 | 65700 |
Michel Haïssaguerre | 117 | 757 | 62284 |
Liquan Chen | 111 | 689 | 44229 |
Marion Leboyer | 110 | 773 | 50767 |
Jean-François Dartigues | 106 | 631 | 46682 |
Alexa S. Beiser | 106 | 366 | 47457 |
Robert Dantzer | 105 | 497 | 46554 |