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Institution

University of Bordeaux

EducationBordeaux, France
About: University of Bordeaux is a education organization based out in Bordeaux, France. It is known for research contribution in the topics: Population & Laser. The organization has 28811 authors who have published 55536 publications receiving 1619635 citations. The organization is also known as: UB.


Papers
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Journal ArticleDOI
TL;DR: Surprisingly, the TIGR message, which is abundantly transcribed in the trabecular meshwork and also in the ciliary body and the sclera, is not expressed in the optic nerve whose degeneration is, however, the primary lesion of POAG.
Abstract: Primary open-angle glaucoma (POAG) is a highly prevalent cause of irreversible blindness which associates cupping of the optic disc and alteration of the visual field, elevation of intraocular pressure being a major risk factor. Provided diagnosis is made at an early stage, treatments are available to prevent visual impairment. A locus, GLC1A, has been mapped on chromosome 1q23-q25 in several families affected with juvenile-onset POAG (JOAG) and also in some families affected with juvenile and middle-age onset POAG. Recently, three mutations of the TIGR (Trabecular meshwork-Induced Glucocorticoid Response) gene were shown to be responsible for the disease in several American families and in unrelated POAG patients. We now describe five new mutations in eight French families. All mutations known to date appear to concentrate in the evolutionarily conserved C-terminal domain of TIGR which bears homology to frog olfactomedin, an extracellular matrix glycoprotein of the olfactory epithelium, to rat and human neuronal olfactomedin-related proteins and to F11C3.2, a protein from Caenorhabditis elegans . Moreover, this conserved domain of TIGR is encoded by a single exon to which mutation screening could be limited. Surprisingly, the TIGR message, which is abundantly transcribed in the trabecular meshwork and also in the ciliary body and the sclera, is not expressed in the optic nerve whose degeneration is, however, the primary lesion of POAG.

302 citations

Journal ArticleDOI
A. A. Abdo1, A. A. Abdo2, Markus Ackermann3, Marco Ajello3  +221 moreInstitutions (40)
TL;DR: The discovery of bright gamma-ray emission coincident with supernova remnant (SNR) W51C is reported using the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope as discussed by the authors.
Abstract: The discovery of bright gamma-ray emission coincident with supernova remnant (SNR) W51C is reported using the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. W51C is a middle-aged remnant (~10^4 yr) with intense radio synchrotron emission in its shell and known to be interacting with a molecular cloud. The gamma-ray emission is spatially extended, broadly consistent with the radio and X-ray extent of SNR W51C. The energy spectrum in the 0.2-50 GeV band exhibits steepening toward high energies. The luminosity is greater than 1x10^{36} erg/s given the distance constraint of D>5.5 kpc, which makes this object one of the most luminous gamma-ray sources in our Galaxy. The observed gamma-rays can be explained reasonably by a combination of efficient acceleration of nuclear cosmic rays at supernova shocks and shock-cloud interactions. The decay of neutral pi-mesons produced in hadronic collisions provides a plausible explanation for the gamma-ray emission. The product of the average gas density and the total energy content of the accelerated protons amounts to 5x10^{51}(D/6kpc)^2 erg/cm^3. Electron density constraints from the radio and X-ray bands render it difficult to explain the LAT signal as due to inverse Compton scattering. The Fermi LAT source coincident with SNR W51C sheds new light on the origin of Galactic cosmic rays.

302 citations

Journal ArticleDOI
TL;DR: It is suggested that the tuning principle in noradrenergic systems is particularly important for the formation of associations and neural plasticity (interference control) and that the switching principle of dopaminergic systems modulates the timing, time-sharing and initiation of responses (program-control).

302 citations

Journal ArticleDOI
26 Jan 2018-Science
TL;DR: A maxilla and associated dentition recently discovered at Misliya Cave, Israel, was dated to 177,000 to 194,000 years ago, suggesting that members of the Homo sapiens clade left Africa earlier than previously thought.
Abstract: To date, the earliest modern human fossils found outside of Africa are dated to around 90,000 to 120,000 years ago at the Levantine sites of Skhul and Qafzeh. A maxilla and associated dentition recently discovered at Misliya Cave, Israel, was dated to 177,000 to 194,000 years ago, suggesting that members of the Homo sapiens clade left Africa earlier than previously thought. This finding changes our view on modern human dispersal and is consistent with recent genetic studies, which have posited the possibility of an earlier dispersal of Homo sapiens around 220,000 years ago. The Misliya maxilla is associated with full-fledged Levallois technology in the Levant, suggesting that the emergence of this technology is linked to the appearance of Homo sapiens in the region, as has been documented in Africa.

302 citations

Journal ArticleDOI
TL;DR: In this paper, the authors obtained new nonlinear systems describing the interaction of long water waves in both two and three dimensions, and showed that solutions of the complete free-surface Euler equations tend to associated solutions of these systems as the amplitude becomes small and the wavelength large.
Abstract: In this paper, we obtain new nonlinear systems describing the interaction of long water waves in both two and three dimensions. These systems are symmetric and conservative. Rigorous convergence results are provided showing that solutions of the complete free-surface Euler equations tend to associated solutions of these systems as the amplitude becomes small and the wavelength large. Using this result as a tool, a rigorous justification of all the two-dimensional, approximate systems recently put forward and analysed by Bona, Chen and Saut is obtained. In the two-dimensional context, our methods also allows a significant improvement of the convergence estimate obtained by Schneider and Wayne in their justification of the decoupled Korteweg-de Vries approximation of the two-dimensional Euler equations. It also follows from our theory that coupled models provide a better description than the decoupled ones over short time scales. Results are obtained both on an unbounded domain for solutions that evanesce at infinity as well as for solutions that are spatially periodic.

301 citations


Authors

Showing all 28995 results

NameH-indexPapersCitations
Nicholas G. Martin1921770161952
George F. Koob171935112521
Daniel J. Jacob16265676530
Arthur W. Toga1591184109343
James M. Tour14385991364
Floyd E. Bloom13961672641
Herbert Y. Meltzer137114881371
Jean-Marie Tarascon136853137673
Stanley Nattel13277865700
Michel Haïssaguerre11775762284
Liquan Chen11168944229
Marion Leboyer11077350767
Jean-François Dartigues10663146682
Alexa S. Beiser10636647457
Robert Dantzer10549746554
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202378
2022393
20213,110
20203,362
20193,245
20183,143