Institution
University of Bordeaux
Education•Bordeaux, France•
About: University of Bordeaux is a education organization based out in Bordeaux, France. It is known for research contribution in the topics: Population & Laser. The organization has 28811 authors who have published 55536 publications receiving 1619635 citations. The organization is also known as: UB.
Topics: Population, Laser, Raman spectroscopy, Polymerization, Crystal structure
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that the presence of both EZs and AMPAR recycling maintain a large pool of mobile AMPARs at synapses, and it is found that synaptic potentiation is accompanied by an accumulation and immobilization of AM PARs atsynapses resulting from both their exocytosis and stabilization at the PSD.
287 citations
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TL;DR: The generality of this optical approach is demonstrated by implementing the operations mentioned above, without the need for any special microfabrication or moving parts, by implementing a wide range of building blocks, such as a droplet valve, sorter, fuser, or divider.
Abstract: The use of microfluidic drops as microreactors hinges on the active control of certain fundamental operations such as droplet formation, transport, division and fusion. Recent work has demonstrated that local heating from a focused laser can apply a thermocapillary force on a liquid interface sufficient to block the advance of a droplet in a microchannel (C. N. Baroud, J.-P. Delville, F. Gallaire and R. Wunenburger, Phys. Rev. E: Stat., Nonlinear, Soft Matter Phys., 2007, 75(4), 046302). Here, we demonstrate the generality of this optical approach by implementing the operations mentioned above, without the need for any special microfabrication or moving parts. We concentrate on the applications to droplet manipulation by implementing a wide range of building blocks, such as a droplet valve, sorter, fuser, or divider. We also show how the building blocks may be combined by implementing a valve and fuser using a single laser spot. The underlying fundamentals, namely regarding the fluid mechanical, physico-chemical and thermal aspects, will be discussed in future publications.
286 citations
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TL;DR: The absorption of a single isolated metal cluster is directly measured using a novel far-field optical technique based on modulation of its position using optically detected single gold nanoparticles dispersed on a transparent substrate.
Abstract: The absorption of a single isolated metal cluster is directly measured using a novel far-field optical technique based on modulation of its position. Single gold nanoparticles with average diameters down to 5 nm, dispersed on a transparent substrate, are optically detected and their absolute absorption cross section determined.
285 citations
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TL;DR: This paper deals with the application of fractional system identification to lead acid battery state of charge estimation and a new fractional model of the battery is proposed based on parameter variations of this model.
285 citations
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TL;DR: The results suggest that increased ATP-ubiquitin-dependent proteolysis is most probably responsible for muscle wasting in the unweighted soleus muscle.
Abstract: Nine days of hindlimb suspension resulted in atrophy (55%) and loss of protein (53%) in rat soleus muscle due to a marked elevation in protein breakdown (66%, P < 0.005). To define which proteolytic system(s) contributed to this increase, soleus muscles from unweighted rats were incubated in the presence of proteolytic inhibitors. An increase in lysosomal and Ca 2+-activated proteolysis (254%, P < 0.05) occurred in the atrophying incubated muscles. In agreement with the measurements in vitro, cathepsin B, cathepsins B + L and m-calpain enzyme activities increased by 111%, 92% and 180% (P < 0.005) respectively in the atrophying muscles. Enhanced mRNA levels for these proteinases (P < 0.05 to P < 0.001) paralleled the increased enzyme activities, suggesting a transcriptional regulation of these enzymes. However, the lysosomal and Ca 2+-dependent proteolytic pathways accounted for a minor part of total proteolysis in both control (9%) and unweighted rats (18%). Furthermore the inhibition of these pathways failed to suppress increased protein breakdown in unweighted muscle. Thus a non-lysosomal Ca 2+-independent proteolytic process essentially accounted for the increased proteolysis and subsequent muscle wasting. Increased mRNA levels for ubiquitin, the 14 kDa ubiquitin-conjugating enzyme E2 (involved in the ubiquitylation of protein substrates) and the C2 and C9 subunits of the 20 S proteasome (i.e. the proteolytic core of the 26 S proteasome that degrades ubiquitin conjugates) were observed in the atrophying muscles (P < 0.02 to P < 0.001). Analysis of C9 mRNA in polyribosomes showed equal distribution into both translationally active and inactive mRNA pools, in either unweighted or control rats. These results suggest that increased ATP-ubiquitin-dependent proteolysis is most probably responsible for muscle wasting in the unweighted soleus muscle.
285 citations
Authors
Showing all 28995 results
Name | H-index | Papers | Citations |
---|---|---|---|
Nicholas G. Martin | 192 | 1770 | 161952 |
George F. Koob | 171 | 935 | 112521 |
Daniel J. Jacob | 162 | 656 | 76530 |
Arthur W. Toga | 159 | 1184 | 109343 |
James M. Tour | 143 | 859 | 91364 |
Floyd E. Bloom | 139 | 616 | 72641 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
Stanley Nattel | 132 | 778 | 65700 |
Michel Haïssaguerre | 117 | 757 | 62284 |
Liquan Chen | 111 | 689 | 44229 |
Marion Leboyer | 110 | 773 | 50767 |
Jean-François Dartigues | 106 | 631 | 46682 |
Alexa S. Beiser | 106 | 366 | 47457 |
Robert Dantzer | 105 | 497 | 46554 |