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Institution

University of Bordeaux

EducationBordeaux, France
About: University of Bordeaux is a education organization based out in Bordeaux, France. It is known for research contribution in the topics: Population & Laser. The organization has 28811 authors who have published 55536 publications receiving 1619635 citations. The organization is also known as: UB.


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Journal ArticleDOI
24 Mar 2016-Cell
TL;DR: An unappreciated physical dimension to lymphocyte function is revealed and cells use mechanical forces to control the activity of outgoing chemical signals and data indicate that CTLs coordinate perforin release and force exertion in space and time.

274 citations

Journal ArticleDOI
Lindsay M. Morton1, Susan L. Slager2, James R. Cerhan2, Sophia S. Wang3, Claire M. Vajdic4, Christine F. Skibola5, Paige M. Bracci6, Silvia de Sanjosé, Karin E. Smedby7, Brian C.-H. Chiu8, Yawei Zhang9, Sam M. Mbulaiteye1, Alain Monnereau10, Jennifer Turner11, Jacqueline Clavel12, Hans-Olov Adami13, Hans-Olov Adami7, Ellen T. Chang14, Ellen T. Chang15, Bengt Glimelius7, Bengt Glimelius16, Henrik Hjalgrim17, Mads Melbye17, Paolo Crosignani, Simonetta Di Lollo18, Lucia Miligi, Oriana Nanni, Valerio Ramazzotti, Stefania Rodella, Adele Seniori Costantini, Emanuele Stagnaro, Rosario Tumino, Carla Vindigni, Paolo Vineis19, Nikolaus Becker20, Yolanda Benavente, Paolo Boffetta21, Paul Brennan22, Pierluigi Cocco23, Lenka Foretova, Marc Maynadié24, Alexandra Nieters25, Anthony Staines26, Joanne S. Colt1, Wendy Cozen27, Scott Davis28, Scott Davis29, Anneclaire J. De Roos30, Patricia Hartge1, Nathaniel Rothman1, Richard K. Severson31, Elizabeth A. Holly6, Timothy G. Call2, Andrew L. Feldman2, Thomas M. Habermann2, Mark Liebow2, Aaron Blair1, Kenneth P. Cantor1, Eleanor Kane32, Tracy Lightfoot32, Eve Roman32, Alex Smith32, Angela Brooks-Wilson33, Angela Brooks-Wilson34, Joseph M. Connors34, Randy D. Gascoyne34, John J. Spinelli34, Bruce K. Armstrong35, Anne Kricker35, Theodore R. Holford9, Qing Lan1, Tongzhang Zheng9, Laurent Orsi12, Luigino Dal Maso, Silvia Franceschi22, Carlo La Vecchia36, Carlo La Vecchia37, Eva Negri37, Diego Serraino, Leslie Bernstein3, Alexandra M. Levine3, Jonathan W. Friedberg38, Jennifer L. Kelly38, Sonja I. Berndt1, Brenda M. Birmann13, Christina A. Clarke39, Christopher R. Flowers40, James M. Foran2, Marshall E. Kadin41, Marshall E. Kadin42, Ora Paltiel, Dennis D. Weisenburger3, Martha S. Linet1, Joshua N. Sampson1 
TL;DR: Using a novel approach to investigate etiologic heterogeneity among NHL subtypes,risk factors that were common among subtypes as well as risk factors that appeared to be distinct among individual or a few subtypes are identified, suggesting both subtype-specific and shared underlying mechanisms.
Abstract: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy and the fifth most common type of cancer in more developed regions of the world (1). Numerous NHL subtypes with distinct combinations of morphologic, immunophenotypic, genetic, and clinical features are currently recognized (2,3). The incidence of NHL subtypes varies substantially by age, sex, and race/ethnicity (4–7). However, the etiological implications of this biological, clinical, and epidemiological diversity are incompletely understood. The importance of investigating etiology by NHL subtype is clearly supported by research on immunosuppression, infections, and autoimmune diseases, which are the strongest and most established risk factors for NHL. Studies of solid organ transplant recipients and individuals infected with HIV demonstrate that risks are markedly increased for several—but not all—NHL subtypes (8–13). Some infections and autoimmune diseases are associated with a single specific subtype [eg, human T-cell lymphotropic virus, type I (HTLV-I) with adult T-cell leukemia/lymphoma (14), celiac disease with enteropathy-type peripheral T-cell lymphoma (PTCL) (15–17)], whereas others [eg, Epstein–Barr virus, hepatitis C virus (HCV), Sjogren’s syndrome (18–21)] have been associated with multiple subtypes. In the last two decades, reports from individual epidemiological studies of NHL have suggested differences in risks among NHL subtypes for a wide range of risk factors, but most studies have lacked the statistical power to assess any differences quantitatively and have not systematically evaluated combinations of subtypes. One study assessed multiple risk factors and found support for both etiologic commonality and heterogeneity for NHL subtypes, with risk factor patterns suggesting that immune dysfunction is of greater etiologic importance for diffuse large B-cell lymphoma (DLBCL) and marginal zone lymphoma than for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and follicular lymphoma (22). However, that analysis was limited to approximately 1300 NHL cases and considered only the four most common NHL subtypes. Pooling data from multiple studies through the International Lymphoma Epidemiology Consortium (InterLymph) have provided substantial insight into associations between specific risk factors and NHL subtypes, with evidence that family history of hematologic malignancy, autoimmune diseases, atopic conditions, lifestyle factors (smoking, alcohol, anthropometric measures, and hair dye use), and sun exposure are associated with NHL risk (19,21,23–32). However, no previous study has compared patterns of risk for a range of exposures for both common and rarer NHL subtypes. We undertook the InterLymph NHL Subtypes Project, a pooled analysis of 20 case–control studies including 17 471 NHL cases and 23 096 controls, to advance understanding of NHL etiology by investigating NHL subtype-specific risks associated with medical history, family history of hematologic malignancy, lifestyle factors, and occupation. The detailed risk factor profiles for each of 11 NHL subtypes appear in this issue (15–17,33–40). In this report, we assess risk factor heterogeneity among the NHL subtypes and identify subtypes that have similar risk factor profiles.

273 citations

Journal ArticleDOI
TL;DR: Transient promoter and yeast two-hybrid assays demonstrated that VvMYC1 physically interacts with MYB5a,MYB5b, MYBA1/A2, and MYBPA1 to induce promoters of flavonoid pathway genes involved in anthocyanin and/or proanthocyanidin (PA) synthesis, and transcript levels during berry development correlate with the synthesis ofAnthocyanins and PAs in skins and seeds of berries.

273 citations

Journal ArticleDOI
TL;DR: In this paper, the authors provided up-to-date information on potential mental health risks associated with exposure of health professionals to the COVID-19 pandemic, and highlighted most relevant data concerning the disease characteristics, the organizational factors and personal factors that may contribute to developing psychological distress and other mental health symptoms.
Abstract: Objectives The coronavirus disease 2019 (COVID-19) pandemic has caused major sanitary crisis worldwide. Half of the world has been placed in quarantine. In France, this large-scale health crisis urgently triggered the restructuring and reorganization of health service delivery to support emergency services, medical intensive care units and continuing care units. Health professionals mobilized all their resources to provide emergency aid in a general climate of uncertainty. Concerns about the mental health, psychological adjustment, and recovery of health care workers treating and caring for patients with COVID-19 are now arising. The goal of the present article is to provide up-to-date information on potential mental health risks associated with exposure of health professionals to the COVID-19 pandemic. Methods Authors performed a narrative review identifying relevant results in the scientific and medical literature considering previous epidemics of 2003 (SARS-CoV-1) and 2009 (H1N1) with the more recent data about the COVID-19 pandemic. We highlighted most relevant data concerning the disease characteristics, the organizational factors and personal factors that may contribute to developing psychological distress and other mental health symptoms. Results The disease characteristics of the current COVID-19 pandemic provoked a generalized climate of wariness and uncertainty, particularly among health professionals, due to a range of causes such as the rapid spread of COVID-19, the severity of symptoms it can cause in a segment of infected individuals, the lack of knowledge of the disease, and deaths among health professionals. Stress may also be caused by organizational factors, such as depletion of personal protection equipment, concerns about not being able to provide competent care if deployed to new area, concerns about rapidly changing information, lack of access to up-to-date information and communication, lack of specific drugs, the shortage of ventilators and intensive care unit beds necessary to care for the surge of critically ill patients, and significant change in their daily social and family life. Further risk factors have been identified, including feelings of being inadequately supported, concerns about health of self, fear of taking home infection to family members or others, and not having rapid access to testing through occupational health if needed, being isolated, feelings of uncertainty and social stigmatization, overwhelming workload, or insecure attachment. Additionally, we discussed positive social and organizational factors that contribute to enhance resilience in the face of the pandemic. There is a consensus in all the relevant literature that health care professionals are at an increased risk of high levels of stress, anxiety, depression, burnout, addiction and post-traumatic stress disorder, which could have long-term psychological implications. Conclusions In the long run, this tragic health crisis should significantly enhance our understanding of the mental health risk factors among the health care professionals facing the COVID-19 pandemic. Reporting information such as this is essential to plan future prevention strategies. Protecting health care professionals is indeed an important component of public health measures to address large-scale health crisis. Thus, interventions to promote mental well-being in health care professionals exposed to COVID-19 need to be immediately implemented, and to strengthen prevention and response strategies by training health care professionals on mental help and crisis management.

272 citations

Journal ArticleDOI
TL;DR: An international group of experts evaluated and revised recommendations for ambulatory reflux monitoring for the diagnosis of gastro‐esophageal reflux disease (GERD).
Abstract: Background An international group of experts evaluated and revised recommendations for ambulatory reflux monitoring for the diagnosis of gastro-esophageal reflux disease (GERD). Methods Literature search was focused on indications and technical recommendations for GERD testing and phenotypes definitions. Statements were proposed and discussed during several structured meetings. Key Results Reflux testing should be performed after cessation of acid suppressive medication in patients with a low likelihood of GERD. In this setting, testing can be either catheter-based or wireless pH-monitoring or pH-impedance monitoring. In patients with a high probability of GERD (esophagitis grade C and D, histology proven Barrett's mucosa >1 cm, peptic stricture, previous positive pH monitoring) and persistent symptoms, pH-impedance monitoring should be performed on treatment. Recommendations are provided for data acquisition and analysis. Esophageal acid exposure is considered as pathological if acid exposure time (AET) is greater than 6% on pH testing. Number of reflux episodes and baseline impedance are exploratory metrics that may complement AET. Positive symptom reflux association is defined as symptom index (SI) >50% or symptom association probability (SAP) >95%. A positive symptom-reflux association in the absence of pathological AET defines hypersensitivity to reflux. Conclusions and Inferences The consensus group determined that grade C or D esophagitis, peptic stricture, histology proven Barrett's mucosa >1 cm, and esophageal acid exposure greater >6% are sufficient to define pathological GERD. Further testing should be considered when none of these criteria are fulfilled.

272 citations


Authors

Showing all 28995 results

NameH-indexPapersCitations
Nicholas G. Martin1921770161952
George F. Koob171935112521
Daniel J. Jacob16265676530
Arthur W. Toga1591184109343
James M. Tour14385991364
Floyd E. Bloom13961672641
Herbert Y. Meltzer137114881371
Jean-Marie Tarascon136853137673
Stanley Nattel13277865700
Michel Haïssaguerre11775762284
Liquan Chen11168944229
Marion Leboyer11077350767
Jean-François Dartigues10663146682
Alexa S. Beiser10636647457
Robert Dantzer10549746554
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202378
2022393
20213,110
20203,362
20193,245
20183,143